Open Access

Regulatory long non‑coding RNAs of hepatic stellate cells in liver fibrosis (Review)

  • Authors:
    • Zhengjie Wu
    • Shunmei Huang
    • Xiaoqin Zheng
    • Silan Gu
    • Qiaomai Xu
    • Yiwen Gong
    • Jiaying Zhang
    • Bin Fu
    • Lingling Tang
  • View Affiliations

  • Published online on: February 11, 2021     https://doi.org/10.3892/etm.2021.9782
  • Article Number: 351
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Liver fibrosis (LF) is a continuous wound healing process caused by numerous chronic hepatic diseases and poses a major threat to human health. Activation of hepatic stellate cells (HSCs) is a critical event in the development of hepatic fibrosis. Long non‑coding RNAs (lncRNAs) that are involved in HSC activation, participate in the development of LF and are likely to be therapeutic targets for LF. In the present review, the cellular signaling pathways of LF with respect to HSCs were discussed. In particular, this present review highlighted the current knowledge on the role of lncRNAs in activating or inhibiting LF, revealing lncRNAs that are likely to be biomarkers or therapeutic targets for LF. Additional studies should be performed to elucidate the potential of lncRNAs in the diagnosis and prognosis of LF and to provide novel therapeutic approaches for the reversion of LF.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wu Z, Huang S, Zheng X, Gu S, Xu Q, Gong Y, Zhang J, Fu B and Tang L: Regulatory long non‑coding RNAs of hepatic stellate cells in liver fibrosis (Review). Exp Ther Med 21: 351, 2021.
APA
Wu, Z., Huang, S., Zheng, X., Gu, S., Xu, Q., Gong, Y. ... Tang, L. (2021). Regulatory long non‑coding RNAs of hepatic stellate cells in liver fibrosis (Review). Experimental and Therapeutic Medicine, 21, 351. https://doi.org/10.3892/etm.2021.9782
MLA
Wu, Z., Huang, S., Zheng, X., Gu, S., Xu, Q., Gong, Y., Zhang, J., Fu, B., Tang, L."Regulatory long non‑coding RNAs of hepatic stellate cells in liver fibrosis (Review)". Experimental and Therapeutic Medicine 21.4 (2021): 351.
Chicago
Wu, Z., Huang, S., Zheng, X., Gu, S., Xu, Q., Gong, Y., Zhang, J., Fu, B., Tang, L."Regulatory long non‑coding RNAs of hepatic stellate cells in liver fibrosis (Review)". Experimental and Therapeutic Medicine 21, no. 4 (2021): 351. https://doi.org/10.3892/etm.2021.9782