Open Access

Recent advances of glucocorticoids in the treatment of Duchenne muscular dystrophy (Review)

  • Authors:
    • Tianyuan Zhang
    • Xiangdong Kong
  • View Affiliations

  • Published online on: March 1, 2021     https://doi.org/10.3892/etm.2021.9875
  • Article Number: 447
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Duchenne muscular dystrophy (DMD) is the most common degenerative neuromuscular disease. The incidence of DMD in live births is 1/3,600‑1/6,000. Although glucocorticoid‑dependent medication is the mainstay treatment option for DMD, a standard treatment regimen has yet to be determined. The present review discusses the literature on the timing, methods and courses of glucocorticoid treatment for DMD. The review highlights the importance of the immediate commencement of glucocorticoid treatment following the diagnosis of DMD, with weekend‑only administration being advantageous. Adherence to long‑term single‑glucocorticoid therapy can delay the loss of ambulation ability, and the side effects of the treatment are controllable. However, the standard medication for patients of different ages and stages of disease development, and the use of combination therapy require further investigation.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang T and Kong X: Recent advances of glucocorticoids in the treatment of Duchenne muscular dystrophy (Review). Exp Ther Med 21: 447, 2021.
APA
Zhang, T., & Kong, X. (2021). Recent advances of glucocorticoids in the treatment of Duchenne muscular dystrophy (Review). Experimental and Therapeutic Medicine, 21, 447. https://doi.org/10.3892/etm.2021.9875
MLA
Zhang, T., Kong, X."Recent advances of glucocorticoids in the treatment of Duchenne muscular dystrophy (Review)". Experimental and Therapeutic Medicine 21.5 (2021): 447.
Chicago
Zhang, T., Kong, X."Recent advances of glucocorticoids in the treatment of Duchenne muscular dystrophy (Review)". Experimental and Therapeutic Medicine 21, no. 5 (2021): 447. https://doi.org/10.3892/etm.2021.9875