Insulin‑like growth factor‑1: A potential target for bronchopulmonary dysplasia treatment (Review)
- Authors:
- Shujian Zhang
- Xue Luan
- Huiwen Li
- Zhengyong Jin
-
Affiliations: Department of Pediatrics, Affiliated Hospital of Yanbian University, Yanji, Jilin 133000, P.R. China, Department of Pediatrics, First Hospital, Jilin University, Changchun, Jilin 130000, P.R. China - Published online on: January 5, 2022 https://doi.org/10.3892/etm.2022.11114
- Article Number: 191
-
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
Hwang JS and Rehan VK: Recent advances in bronchopulmonary dysplasia: Pathophysiology, prevention, and treatment. Lung. 196:129–138. 2018.PubMed/NCBI View Article : Google Scholar | |
Bancalari E and Jain D: Bronchopulmonary dysplasia: 50 Years after the original description. Neonatology. 115:384–391. 2019.PubMed/NCBI View Article : Google Scholar | |
Northway WH Jr, Rosan RC and Porter DY: Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 276:357–368. 1967.PubMed/NCBI View Article : Google Scholar | |
Chen S, Wu Q, Zhong D, Li C and Du L: Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathway. Respir Res. 21(140)2020.PubMed/NCBI View Article : Google Scholar | |
Principi N, Di Pietro GM and Esposito S: Bronchopulmonary dysplasia: Clinical aspects and preventive and therapeutic strategies. J Transl Med. 16(36)2018.PubMed/NCBI View Article : Google Scholar | |
Sahni M and Bhandari V: Recent advances in understanding and management of bronchopulmonary dysplasia. F1000Res 9: F1000 Faculty Rev-703, 2020. | |
Thébaud B, Goss KN, Laughon M, Whitsett JA, Abman SH, Steinhorn RH, Aschner JL, Davis PG, McGrath-Morrow SA, Soll RF and Jobe AH: Bronchopulmonary dysplasia. Nat Rev Dis Primers. 5(78)2019.PubMed/NCBI View Article : Google Scholar | |
Lavoie PM and Dubé MP: Genetics of bronchopulmonary dysplasia in the age of genomics. Curr Opin Pediatr. 22:134–138. 2010.PubMed/NCBI View Article : Google Scholar | |
Trembath A and Laughon MM: Predictors of bronchopulmonary dysplasia. Clin Perinatol. 39:585–601. 2012.PubMed/NCBI View Article : Google Scholar | |
Collaco JM, Romer LH, Stuart BD, Coulson JD, Everett AD, Lawson EE, Brenner JI, Brown AT, Nies MK, Sekar P, et al: Frontiers in pulmonary hypertension in infants and children with bronchopulmonary dysplasia. Pediatr Pulmonol. 47:1042–1053. 2012.PubMed/NCBI View Article : Google Scholar | |
Liu Y and Dong WB: Preventive effect of caffeine on bronchopulmonary dysplasia in preterm infants. Zhongguo Dang Dai Er Ke Za Zhi. 20:598–602. 2018.PubMed/NCBI View Article : Google Scholar : (In Chinese). | |
Bhandari A and Panitch HB: Pulmonary outcomes in bronchopulmonary dysplasia. Semin Perinatol. 30:219–226. 2006.PubMed/NCBI View Article : Google Scholar | |
Davidson LM and Berkelhamer SK: Bronchopulmonary dysplasia: Chronic lung disease of infancy and Long-Term pulmonary outcomes. J Clin Med. 6(4)2017.PubMed/NCBI View Article : Google Scholar | |
Postma DS, Bush A and van den Berge M: Risk factors and early origins of chronic obstructive pulmonary disease. Lancet. 385:899–909. 2015.PubMed/NCBI View Article : Google Scholar | |
Sucre J, Haist L, Bolton CE and Hilgendorff A: Early changes and indicators characterizing lung aging in neonatal chronic lung disease. Front Med (Lausanne). 8(665152)2021.PubMed/NCBI View Article : Google Scholar | |
Pakvasa MA, Saroha V and Patel RM: Optimizing caffeine use and risk of bronchopulmonary dysplasia in preterm infants: A systematic review, Meta-analysis, and application of grading of recommendations assessment, development, and evaluation methodology. Clin Perinatol. 45:273–291. 2018.PubMed/NCBI View Article : Google Scholar | |
Baud O and Watterberg KL: Prophylactic postnatal corticosteroids: Early hydrocortisone. Semin Fetal Neonatal Med. 24:202–206. 2019.PubMed/NCBI View Article : Google Scholar | |
Askie LM, Davies LC, Schreiber MD, Hibbs AM, Ballard PL and Ballard RA: Race effects of inhaled nitric oxide in preterm infants: An individual participant data Meta-Analysis. J Pediatr. 193:34–39.e2. 2018.PubMed/NCBI View Article : Google Scholar | |
Thompson EJ, Greenberg RG, Kumar K, Laughon M, Smith PB, Clark RH, Crowell A, Shaw L, Harrison L, Scales G, et al: Association between furosemide exposure and patent ductus arteriosus in hospitalized infants of very low birth weight. J Pediatr. 199:231–236. 2018.PubMed/NCBI View Article : Google Scholar | |
Augustine S, Cheng W, Avey MT, Chan ML, Lingappa SM, Hutton B and Thébaud B: Are all stem cells equal? Systematic review, evidence map, and meta-analyses of preclinical stem cell-based therapies for bronchopulmonary dysplasia. Stem Cells Transl Med. 9:158–168. 2020.PubMed/NCBI View Article : Google Scholar | |
Hellstrom A, Ley D, Hallberg B, Lofqvist C, Hansen-Pupp I, Ramenghi LA, Borg J, Smith LE and Hard AL: IGF-1 as a drug for preterm infants: A Step-Wise clinical development. Curr Pharm Des. 23:5964–5970. 2017.PubMed/NCBI View Article : Google Scholar | |
Wang Z, Li W, Guo Q, Wang Y, Ma L and Zhang X: Insulin-Like Growth Factor-1 Signaling in lung development and inflammatory lung diseases. Biomed Res Int. 2018(6057589)2018.PubMed/NCBI View Article : Google Scholar | |
Chetty A, Andersson S, Lassus P and Nielsen HC: Insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) expression in human lung in RDS and BPD. Pediatr Pulmonol. 37:128–136. 2004.PubMed/NCBI View Article : Google Scholar | |
Belcastro R, Lopez L, Li J, Masood A and Tanswell AK: Chronic lung injury in the neonatal rat: Up-regulation of TGFβ1 and nitration of IGF-R1 by peroxynitrite as likely contributors to impaired alveologenesis. Free Radic Biol Med. 80:1–11. 2015.PubMed/NCBI View Article : Google Scholar | |
Banjac L, Kotur-Stevuljević J, Gojković T, Bokan-Mirković V and Banjac G and Banjac G: Relationship between insulin-like growth factor type 1 and intrauterine growth. Acta Clin Croat. 59:91–96. 2020.PubMed/NCBI View Article : Google Scholar | |
Salaets T, Aertgeerts M, Gie A, Vignero J, de Winter D, Regin Y, Jimenez J, Vande Velde G, Allegaert K, Deprest J and Toelen J: Preterm birth impairs postnatal lung development in the neonatal rabbit model. Respir Res. 21(59)2020.PubMed/NCBI View Article : Google Scholar | |
Dumpa V and Bhandari V: Surfactant, steroids and non-invasive ventilation in the prevention of BPD. Semin Perinatol. 42:444–452. 2018.PubMed/NCBI View Article : Google Scholar | |
Day CL and Ryan RM: Bronchopulmonary dysplasia: New becomes old again! Pediatr Res. 81:210–213. 2017.PubMed/NCBI View Article : Google Scholar | |
Collaco JM and McGrath-Morrow SA: Respiratory phenotypes for preterm infants, children, and adults: Bronchopulmonary dysplasia and more. Ann Am Thorac Soc. 15:530–538. 2018.PubMed/NCBI View Article : Google Scholar | |
Bancalari E and Jain D: Bronchopulmonary dysplasia: Can we agree on a definition? Am J Perinatol. 35:537–540. 2018.PubMed/NCBI View Article : Google Scholar | |
Jensen EA and Wright CJ: Bronchopulmonary dysplasia: The ongoing search for one definition to rule them all. J Pediatr. 197:8–10. 2018.PubMed/NCBI View Article : Google Scholar | |
Philip AG: Chronic lung disease of prematurity: A short history. Semin Fetal Neonatal Med. 14:333–338. 2009.PubMed/NCBI View Article : Google Scholar | |
Jobe AH and Bancalari E: Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 163:1723–1729. 2001.PubMed/NCBI View Article : Google Scholar | |
Jensen EA, Dysart K, Gantz MG, McDonald S, Bamat NA, Keszler M, Kirpalani H, Laughon MM, Poindexter BB, Duncan AF, et al: The diagnosis of bronchopulmonary dysplasia in very preterm infants. An Evidence-based approach. Am J Respir Crit Care Med. 200:751–759. 2019.PubMed/NCBI View Article : Google Scholar | |
Islam JY, Keller RL, Aschner JL, Hartert TV and Moore PE: Understanding the Short- and Long-Term respiratory outcomes of prematurity and bronchopulmonary dysplasia. Am J Respir Crit Care Med. 192:134–156. 2015.PubMed/NCBI View Article : Google Scholar | |
Haggie S, Robinson P, Selvadurai H and Fitzgerald DA: Bronchopulmonary dysplasia: A review of the pulmonary sequelae in the post-surfactant era. J Paediatr Child Health. 56:680–689. 2020.PubMed/NCBI View Article : Google Scholar | |
Cox AM, Gao Y, Perl AT, Tepper RS and Ahlfeld SK: Cumulative effects of neonatal hyperoxia on murine alveolar structure and function. Pediatr Pulmonol. 52:616–624. 2017.PubMed/NCBI View Article : Google Scholar | |
Niedermaier S and Hilgendorff A: Bronchopulmonary dysplasia-an overview about pathophysiologic concepts. Mol Cell Pediatr. 2(2)2015.PubMed/NCBI View Article : Google Scholar | |
Balaji S, Dong X, Li H, Zhang Y, Steen E and Lingappan K: Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: Implications for bronchopulmonary dysplasia. Physiol Genomics. 50:940–946. 2018.PubMed/NCBI View Article : Google Scholar | |
Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ and Bhandari V: Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway. Am J Respir Cell Mol Biol. 48:749–757. 2013.PubMed/NCBI View Article : Google Scholar | |
Teng RJ, Jing X, Michalkiewicz T, Afolayan AJ, Wu TJ and Konduri GG: Attenuation of endoplasmic reticulum stress by caffeine ameliorates hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 312:L586–L598. 2017.PubMed/NCBI View Article : Google Scholar | |
Galán M, Kassan M, Kadowitz PJ, Trebak M, Belmadani S and Matrougui K: Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction. Biochim Biophys Acta. 1843:1063–1075. 2014.PubMed/NCBI View Article : Google Scholar | |
Pan J, Zhan C, Yuan T, Wang W, Shen Y, Sun Y, Wu T, Gu W, Chen L and Yu H: Effects and molecular mechanisms of intrauterine infection/inflammation on lung development. Respir Res. 19(93)2018.PubMed/NCBI View Article : Google Scholar | |
Laube M, Amann E, Uhlig U, Yang Y, Fuchs HW, Zemlin M, Mercier JC, Maier RF, Hummler HD, Uhlig S and Thome UH: Inflammatory mediators in tracheal aspirates of preterm infants participating in a randomized trial of inhaled nitric oxide. PLoS One. 12(e0169352)2017.PubMed/NCBI View Article : Google Scholar | |
Savani RC: Modulators of inflammation in bronchopulmonary dysplasia. Semin Perinatol. 42:459–470. 2018.PubMed/NCBI View Article : Google Scholar | |
Ghosh C and Wojtowycz M: Effect of gestational disorders on preterm birth, low birthweight, and NICU admission. Arch Gynecol Obstet. 303:419–426. 2021.PubMed/NCBI View Article : Google Scholar | |
Papagianis PC, Pillow JJ and Moss TJ: Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies. Paediatr Respir Rev. 30:34–41. 2019.PubMed/NCBI View Article : Google Scholar | |
Cui TX, Brady AE, Fulton CT, Zhang YJ, Rosenbloom LM, Goldsmith AM, Moore BB and Popova AP: CCR2 Mediates Chronic LPS-Induced pulmonary inflammation and hypoalveolarization in a murine model of bronchopulmonary dysplasia. Front Immunol. 11(579628)2020.PubMed/NCBI View Article : Google Scholar | |
Kalikkot Thekkeveedu R, Guaman MC and Shivanna B: Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology. Respir Med. 132:170–177. 2017.PubMed/NCBI View Article : Google Scholar | |
Kumar VH, Lakshminrusimha S, Kishkurno S, Paturi BS, Gugino SF, Nielsen L, Wang H and Ryan RM: Neonatal hyperoxia increases airway reactivity and inflammation in adult mice. Pediatr Pulmonol. 51:1131–1141. 2016.PubMed/NCBI View Article : Google Scholar | |
D'Angio CT, Ambalavanan N, Carlo WA, McDonald SA, Skogstrand K, Hougaard DM, Shankaran S, Goldberg RN, Ehrenkranz RA, Tyson JE, et al: Blood cytokine profiles associated with distinct patterns of bronchopulmonary dysplasia among extremely low birth weight infants. J Pediatr. 174:45–51.e5. 2016.PubMed/NCBI View Article : Google Scholar | |
Balany J and Bhandari V: Understanding the impact of infection, inflammation, and their persistence in the pathogenesis of bronchopulmonary dysplasia. Front Med (Lausanne). 2(90)2015.PubMed/NCBI View Article : Google Scholar | |
Torchin H, Ancel PY, Goffinet F, Hascoët JM, Truffert P, Tran D, Lebeaux C and Jarreau PH: Placental complications and bronchopulmonary dysplasia: EPIPAGE-2 Cohort Study. Pediatrics. 137(e20152163)2016.PubMed/NCBI View Article : Google Scholar | |
Bhandari V and Lodha A: Is bronchopulmonary dysplasia decided before birth? Pediatr Res. 87:809–810. 2020.PubMed/NCBI View Article : Google Scholar | |
Pammi M, Lal CV, Wagner BD, Mourani PM, Lohmann P, Luna RA, Sisson A, Shivanna B, Hollister EB, Abman SH, et al: Airway microbiome and development of bronchopulmonary dysplasia in preterm infants: A systematic review. J Pediatr. 204:126–133.e2. 2019.PubMed/NCBI View Article : Google Scholar | |
Surate Solaligue DE, Rodríguez-Castillo JA, Ahlbrecht K and Morty RE: Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 313:L1101–L1153. 2017.PubMed/NCBI View Article : Google Scholar | |
Lewin G and Hurtt ME: Pre- and Postnatal lung development: An updated species comparison. Birth Defects Res. 109:1519–1539. 2017.PubMed/NCBI View Article : Google Scholar | |
Segerer FJ and Speer CP: Lung function in childhood and adolescence: Influence of prematurity and bronchopulmonary dysplasia. Z Geburtshilfe Neonatol. 220:147–154. 2016.PubMed/NCBI View Article : Google Scholar : (In German). | |
Landry JS, Tremblay GM, Li PZ, Wong C, Benedetti A and Taivassalo T: Lung function and bronchial hyperresponsiveness in adults born prematurely. A Cohort study. Ann Am Thorac Soc. 13:17–24. 2016.PubMed/NCBI View Article : Google Scholar | |
Saarenpää HK, Tikanmäki M, Sipola-Leppänen M, Hovi P, Wehkalampi K, Siltanen M, Vääräsmäki M, Järvenpää AL, Eriksson JG, Andersson S and Kajantie E: Lung function in very low birth weight adults. Pediatrics. 136:642–650. 2015.PubMed/NCBI View Article : Google Scholar | |
Kotecha SJ, Edwards MO, Watkins WJ, Henderson AJ, Paranjothy S, Dunstan FD and Kotecha S: Effect of preterm birth on later FEV1: A systematic review and meta-analysis. Thorax. 68:760–766. 2013.PubMed/NCBI View Article : Google Scholar | |
Salmon WD Jr and Daughaday WH: A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 49:825–836. 1957.PubMed/NCBI | |
Dulak NC and Temin HM: A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication-stimulating activity for embryo fibroblasts. J Cell Physiol. 81:153–160. 1973.PubMed/NCBI View Article : Google Scholar | |
Rinderknecht E and Humbel RE: The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 253:2769–2776. 1978.PubMed/NCBI | |
Bortvedt SF and Lund PK: Insulin-like growth factor 1: Common mediator of multiple enterotrophic hormones and growth factors. Curr Opin Gastroenterol. 28:89–98. 2012.PubMed/NCBI View Article : Google Scholar | |
Piñeiro-Hermida S, López IP, Alfaro-Arnedo E, Torrens R, Iñiguez M, Alvarez-Erviti L, Ruíz-Martínez C and Pichel JG: IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model. Sci Rep. 7(4290)2017.PubMed/NCBI View Article : Google Scholar | |
Vitale G, Pellegrino G, Vollery M and Hofland LJ: ROLE of IGF-1 system in the modulation of Longevity: Controversies and new insights from a Centenarians' Perspective. Front Endocrinol (Lausanne). 10(27)2019.PubMed/NCBI View Article : Google Scholar | |
López IP, Piñeiro-Hermida S, Pais RS, Torrens R, Hoeflich A and Pichel JG: Involvement of Igf1r in bronchiolar epithelial regeneration: Role during repair kinetics after selective club cell ablation. PLoS One. 11(e0166388)2016.PubMed/NCBI View Article : Google Scholar | |
Narasaraju TA, Chen H, Weng T, Bhaskaran M, Jin N, Chen J, Chen Z, Chinoy MR and Liu L: Expression profile of IGF system during lung injury and recovery in rats exposed to hyperoxia: A possible role of IGF-1 in alveolar epithelial cell proliferation and differentiation. J Cell Biochem. 97:984–998. 2006.PubMed/NCBI View Article : Google Scholar | |
Moreno-Barriuso N, López-Malpartida AV, de Pablo F and Pichel JG: Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn. 235:2040–2050. 2006.PubMed/NCBI View Article : Google Scholar | |
Liu JP, Baker J, Perkins AS, Robertson EJ and Efstratiadis A: Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 75:59–72. 1993.PubMed/NCBI | |
Clement A and Eber E: Interstitial lung diseases in infants and children. Eur Respir J. 31:658–666. 2008.PubMed/NCBI View Article : Google Scholar | |
Li H, Batth IS, Qu X, Xu L, Song N, Wang R and Liu Y: IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: Overview and new insights. Mol Cancer. 16(6)2017.PubMed/NCBI View Article : Google Scholar | |
Günschmann C, Stachelscheid H, Akyüz MD, Schmitz A, Missero C, Brüning JC and Niessen CM: Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev Cell. 26:176–187. 2013.PubMed/NCBI View Article : Google Scholar | |
Ahamed K, Epaud R, Holzenberger M, Bonora M, Flejou JF, Puard J, Clement A and Henrion-Caude A: Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury. Respir Res. 6(31)2005.PubMed/NCBI View Article : Google Scholar | |
Mourani PM, Mandell EW, Meier M, Younoszai A, Brinton JT, Wagner BD, Arjaans S, Poindexter BB and Abman SH: Early pulmonary vascular disease in preterm infants is associated with late respiratory outcomes in childhood. Am J Respir Crit Care Med. 199:1020–1027. 2019.PubMed/NCBI View Article : Google Scholar | |
Li J, Masood A, Yi M, Lau M, Belcastro R, Ivanovska J, Jankov RP and Tanswell AK: The IGF-I/IGF-R1 pathway regulates postnatal lung growth and is a nonspecific regulator of alveologenesis in the neonatal rat. Am J Physiol Lung Cell Mol Physiol. 304:L626–L637. 2013.PubMed/NCBI View Article : Google Scholar | |
Hellström A, Ley D, Hansen-Pupp I, Hallberg B, Löfqvist C, van Marter L, van Weissenbruch M, Ramenghi LA, Beardsall K, Dunger D, et al: Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 105:576–586. 2016.PubMed/NCBI View Article : Google Scholar | |
Hirsch K, Taglauer E, Seedorf G, Callahan C, Mandell E, White CW, Kourembanas S and Abman SH: Perinatal Hypoxia-Inducible factor stabilization preserves lung alveolar and vascular growth in experimental bronchopulmonary dysplasia. Am J Respir Crit Care Med. 202:1146–1158. 2020.PubMed/NCBI View Article : Google Scholar | |
Higashi Y, Gautam S, Delafontaine P and Sukhanov S: IGF-1 and cardiovascular disease. Growth Horm IGF Res. 45:6–16. 2019.PubMed/NCBI View Article : Google Scholar | |
Stahl A, Connor KM, Sapieha P, Chen J, Dennison RJ, Krah NM, Seaward MR, Willett KL, Aderman CM, Guerin KI, et al: The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 51:2813–2826. 2010.PubMed/NCBI View Article : Google Scholar | |
Seedorf G, Kim C, Wallace B, Mandell EW, Nowlin T, Shepherd D and Abman SH: rhIGF-1/BP3 preserves lung growth and prevents pulmonary hypertension in experimental bronchopulmonary dysplasia. Am J Respir Crit Care Med. 201:1120–1134. 2020.PubMed/NCBI View Article : Google Scholar | |
Capoluongo E, Vento G, Ameglio F, Lulli P, Matassa PG, Carrozza C, Santini SA, Antenucci M, Castagnola M, Giardina B, et al: Increased levels of IGF-1 and beta2-microglobulin in epithelial lining fluid of preterm newborns developing chronic lung disease effects of rhG-CSF. Int J Immunopathol Pharmacol. 19:57–66. 2006.PubMed/NCBI | |
Klevebro S, Hellgren G, Hansen-Pupp I, Wackernagel D, Hallberg B, Borg J, Pivodic A, Smith L, Ley D and Hellström A: Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1/rhIGFBP-3 in extremely preterm infants. Growth Horm IGF Res. 50:1–8. 2020.PubMed/NCBI View Article : Google Scholar | |
Jin ZA, Jin ZY, Chi YX and Lu JR: Effects of recombinant human insulin-like growth factor-1 on the expression of Clara cell secretory protein in lung of hyperoxia-exposed newborn rats. Zhonghua Er Ke Za Zhi. 45:369–373. 2007.PubMed/NCBI(In Chinese). | |
Guzmán-Bárcenas J, Calderón-Moore A, Baptista-González H and Irles C: Clara cell protein expression in mechanically ventilated term and preterm infants with respiratory distress syndrome and at risk of bronchopulmonary dysplasia: A Pilot study. Can Respir J. 2017(8074678)2017.PubMed/NCBI View Article : Google Scholar | |
Löfqvist C, Niklasson A, Engström E, Friberg LE, Camacho-Hübner C, Ley D, Borg J, Smith LE and Hellström A: A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants. Pediatr Res. 65:574–579. 2009.PubMed/NCBI View Article : Google Scholar | |
Ley D, Hansen-Pupp I, Niklasson A, Domellöf M, Friberg LE, Borg J, Löfqvist C, Hellgren G, Smith LE, Hård AL and Hellström A: Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants: Pharmacokinetics and short-term safety. Pediatr Res. 73:68–74. 2013.PubMed/NCBI View Article : Google Scholar | |
Chung JK, Hallberg B, Hansen-Pupp I, Graham MA, Fetterly G, Sharma J, Tocoian A, Kreher NC, Barton N, Hellström A and Ley D: Development and verification of a pharmacokinetic model to optimize physiologic replacement of rhIGF-1/rhIGFBP-3 in preterm infants. Pediatr Res. 81:504–510. 2017.PubMed/NCBI View Article : Google Scholar | |
Ley D, Hallberg B, Hansen-Pupp I, Dani C, Ramenghi LA, Marlow N, Beardsall K, Bhatti F, Dunger D, Higginson JD, et al: rhIGF-1/rhIGFBP-3 in preterm infants: A Phase 2 Randomized Controlled Trial. J Pediatr. 206:56–65.e8. 2019.PubMed/NCBI View Article : Google Scholar |