Open Access

Advances in cellular senescence in idiopathic pulmonary fibrosis (Review)

  • Authors:
    • Shan Han
    • Qiangwei Lu
    • Xiaoqiu Liu
  • View Affiliations

  • Published online on: February 15, 2023     https://doi.org/10.3892/etm.2023.11844
  • Article Number: 145
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible and fatal interstitial lung disease of unknown cause, with a median survival of 2‑3 years. Its pathogenesis is unclear and there is currently no effective treatment for IPF. Approximately two‑thirds of patients with IPF are >60 years old, with a mean age of 66 years, suggesting a link between aging and IPF. However, the mechanism by which aging promotes development of PF remains unclear. Senescence of alveolar epithelial cells and lung fibroblasts (LFs) and their senescence‑associated secretion phenotype (SASP) may be involved in the occurrence and development of IPF. The present review focus on senescence of LFs and epithelial and stem cells, as well as SASP, the activation of profibrotic signaling pathways and potential treatments for pathogenesis of IPF.
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April-2023
Volume 25 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Han S, Lu Q and Liu X: Advances in cellular senescence in idiopathic pulmonary fibrosis (Review). Exp Ther Med 25: 145, 2023.
APA
Han, S., Lu, Q., & Liu, X. (2023). Advances in cellular senescence in idiopathic pulmonary fibrosis (Review). Experimental and Therapeutic Medicine, 25, 145. https://doi.org/10.3892/etm.2023.11844
MLA
Han, S., Lu, Q., Liu, X."Advances in cellular senescence in idiopathic pulmonary fibrosis (Review)". Experimental and Therapeutic Medicine 25.4 (2023): 145.
Chicago
Han, S., Lu, Q., Liu, X."Advances in cellular senescence in idiopathic pulmonary fibrosis (Review)". Experimental and Therapeutic Medicine 25, no. 4 (2023): 145. https://doi.org/10.3892/etm.2023.11844