Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

Zheng,Qinyun; Xia,Bingxin; Huang,Xianlong; Luo,Jie; Zhong,Shigen; Li,Xuelin

doi:10.3892/etm.2023.11869

Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

Authors:
- Qinyun Zheng
- Bingxin Xia
- Xianlong Huang
- Jie Luo
- Shigen Zhong
- Xuelin Li
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Affiliations: Department of Health Management Centre, Chongqing General Hospital, Chongqing 401147, P.R. China, Department of Health Management Centre, Chongqing General Hospital, Chongqing 401147, P.R. China, College of Biomedical Engineering, Chongqing Medical University, Chongqing 401147, P.R. China
Published online on: March 3, 2023 https://doi.org/10.3892/etm.2023.11869
Article Number: 170
Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

High‑intensity focused ultrasound (HIFU) is a promising and representative non‑invasive therapeutic method for treating cancer with a high degree of efficacy. This non‑invasive method induces tumour cell necrosis by increasing the local temperature and mechanical pressure. However, the clinical application of HIFU is limited given its low penetration depth and the incidence of off‑target side effects. With their promising structural adjustability and targeting ability, nanomedicines have been adopted to improve the ablative efficacy of HIFU in the treatment of cancer. By selectively changing the acoustic environment (tissue structure, density and blood supply) of tumour tissue, these nanomedicines may allow for lower HIFU doses and treatment duration, while additionally achieving a higher degree of efficacy. The use of nanomedicines may also enable cancer theranostics of HIFU, allowing for precise cancer therapeutics. The present review aimed to provide an overview of advances in nanomedicines for HIFU cancer treatment and theranostics, stating their current limitations and future perspectives.

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