Hyperprogressive disease after immune checkpoint inhibitor therapy in a patient with non‑small cell lung cancer who harbors a TGFBR2 mutation: A case report

  • Authors:
    • Xiaofang Wang
    • Xiao Mi
    • Teng Li
    • Chengcheng Li
  • View Affiliations

  • Published online on: March 30, 2023     https://doi.org/10.3892/etm.2023.11927
  • Article Number: 228
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Abstract

We previously demonstrated that a transforming growth factor β type II receptor (TGFBR2) mutation can predict resistance to immune checkpoint inhibitors (ICIs) in patients with advanced non‑small cell lung cancer (NSCLC), based on publicly available immunotherapeutic cohorts. However, the efficacy of ICI‑based regimens in patients with advanced NSCLC harboring TGFBR2 mutations in the real‑world setting is rarely reported. The present study describes the case of a patient with advanced NSCLC who harbors a TGFBR2 mutation. The patient was treated with ICI monotherapy and experienced hyperprogressive disease (HPD). The clinical information was retrospectively collected. The progression‑free survival (PFS) was only 1.3 months. In conclusion, HPD occurred in a patient with advanced NSCLC with a TGFBR2 mutation who received an ICI monotherapy regimen. The findings suggested that caution may be required regarding the clinical delivery of ICI monotherapy to patients with NSCLC and TGFBR2 mutations; ICIs combined with chemotherapy may be an alternative treatment option.
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May-2023
Volume 25 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang X, Mi X, Li T and Li C: Hyperprogressive disease after immune checkpoint inhibitor therapy in a patient with non‑small cell lung cancer who harbors a TGFBR2 mutation: A case report. Exp Ther Med 25: 228, 2023.
APA
Wang, X., Mi, X., Li, T., & Li, C. (2023). Hyperprogressive disease after immune checkpoint inhibitor therapy in a patient with non‑small cell lung cancer who harbors a TGFBR2 mutation: A case report. Experimental and Therapeutic Medicine, 25, 228. https://doi.org/10.3892/etm.2023.11927
MLA
Wang, X., Mi, X., Li, T., Li, C."Hyperprogressive disease after immune checkpoint inhibitor therapy in a patient with non‑small cell lung cancer who harbors a TGFBR2 mutation: A case report". Experimental and Therapeutic Medicine 25.5 (2023): 228.
Chicago
Wang, X., Mi, X., Li, T., Li, C."Hyperprogressive disease after immune checkpoint inhibitor therapy in a patient with non‑small cell lung cancer who harbors a TGFBR2 mutation: A case report". Experimental and Therapeutic Medicine 25, no. 5 (2023): 228. https://doi.org/10.3892/etm.2023.11927