Open Access

Alzheimer's disease, a metabolic disorder: Clinical advances and basic model studies (Review)

  • Authors:
    • Shanhu Zhou
    • Limin Tu
    • Wei Chen
    • Gangli Yan
    • Hongmei Guo
    • Xinhua Wang
    • Qian Hu
    • Huiqing Liu
    • Fengguang Li
  • View Affiliations

  • Published online on: December 14, 2023     https://doi.org/10.3892/etm.2023.12351
  • Article Number: 63
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Alzheimer's disease (AD) is a type of neurodegenerative disease characterized by cognitive impairment that is aggravated with age. The pathological manifestations include extracellular amyloid deposition, intracellular neurofibrillary tangles and loss of neurons. As the world population ages, the incidence of AD continues to increase, not only posing a significant threat to the well‑being and health of individuals but also bringing a heavy burden to the social economy. There is epidemiological evidence suggesting a link between AD and metabolic diseases, which share pathological similarities. This potential link would deserve further consideration; however, the pathogenesis and therapeutic efficacy of AD remain to be further explored. The complex pathogenesis and pathological changes of AD pose a great challenge to the choice of experimental animal models. To understand the role of metabolic diseases in the development of AD and the potential use of drugs for metabolic diseases, the present article reviews the research progress of the comorbidity of AD with diabetes, obesity and hypercholesterolemia, and summarizes the different roles of animal models in the study of AD to provide references for researchers.
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February-2024
Volume 27 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou S, Tu L, Chen W, Yan G, Guo H, Wang X, Hu Q, Liu H and Li F: Alzheimer's disease, a metabolic disorder: Clinical advances and basic model studies (Review). Exp Ther Med 27: 63, 2024.
APA
Zhou, S., Tu, L., Chen, W., Yan, G., Guo, H., Wang, X. ... Li, F. (2024). Alzheimer's disease, a metabolic disorder: Clinical advances and basic model studies (Review). Experimental and Therapeutic Medicine, 27, 63. https://doi.org/10.3892/etm.2023.12351
MLA
Zhou, S., Tu, L., Chen, W., Yan, G., Guo, H., Wang, X., Hu, Q., Liu, H., Li, F."Alzheimer's disease, a metabolic disorder: Clinical advances and basic model studies (Review)". Experimental and Therapeutic Medicine 27.2 (2024): 63.
Chicago
Zhou, S., Tu, L., Chen, W., Yan, G., Guo, H., Wang, X., Hu, Q., Liu, H., Li, F."Alzheimer's disease, a metabolic disorder: Clinical advances and basic model studies (Review)". Experimental and Therapeutic Medicine 27, no. 2 (2024): 63. https://doi.org/10.3892/etm.2023.12351