Open Access

MicroRNAs in chronic pediatric diseases (Review)

  • Authors:
    • Mingyao Zhang
    • Yanhua Han
  • View Affiliations

  • Published online on: January 15, 2024     https://doi.org/10.3892/etm.2024.12388
  • Article Number: 100
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs are small non‑coding RNAs with a length of 20‑24 nucleotides. They bind to the 3'‑untranslated region of target genes to induce the degradation of target mRNAs or inhibit their translation. Therefore, they are involved in the regulation of development, apoptosis, proliferation, differentiation and other biological processes (including hormone secretion, signaling and viral infections). Chronic diseases in children may be difficult to treat and are often associated with malnutrition resulting from a poor diet. Consequently, further complications, disease aggravation and increased treatment costs impose a burden on patients and their families. Existing evidence suggests that microRNAs are involved in various chronic non‑neoplastic diseases in children. The present review discusses the roles of microRNAs in five major chronic diseases in children, namely, diabetes mellitus, congenital heart diseases, liver diseases, bronchial asthma and epilepsy, providing a theoretical basis for them to become therapeutic biomarkers in chronic pediatric diseases.
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March-2024
Volume 27 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang M and Han Y: MicroRNAs in chronic pediatric diseases (Review). Exp Ther Med 27: 100, 2024.
APA
Zhang, M., & Han, Y. (2024). MicroRNAs in chronic pediatric diseases (Review). Experimental and Therapeutic Medicine, 27, 100. https://doi.org/10.3892/etm.2024.12388
MLA
Zhang, M., Han, Y."MicroRNAs in chronic pediatric diseases (Review)". Experimental and Therapeutic Medicine 27.3 (2024): 100.
Chicago
Zhang, M., Han, Y."MicroRNAs in chronic pediatric diseases (Review)". Experimental and Therapeutic Medicine 27, no. 3 (2024): 100. https://doi.org/10.3892/etm.2024.12388