Open Access

Prognostic significance of serum dynamin‑related protein 1 in patients with heart failure: Findings from a prospective observational study

  • Authors:
    • Cheng Cheng
    • Zhong-Guo Fan
    • Ming-Yue Ji
    • Yang Xu
    • Sheng-Hu He
    • Gen-Shan Ma
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  • Published online on: January 29, 2024     https://doi.org/10.3892/etm.2024.12404
  • Article Number: 115
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mitochondrial dysfunction plays a critical role in the development and exacerbation of heart failure (HF). Dynamin‑related protein 1 (Drp1), a key regulator of mitochondrial fission, influences cardiac energy metabolism. The present study investigated the relationship between serum Drp1 levels and the prognosis of patients with HF across a broad spectrum. Serum Drp1 concentrations were measured using ELISA. The primary outcome was the risk of composite major adverse cardiac events (MACEs), which included instances of cardiac death and HF‑related readmissions. To assess the prognostic significance of serum Drp1, a receiver operating characteristic curve was constructed to predict MACE‑free survival. Additionally, an optimal threshold value for Drp1 was determined and was used to stratify patients into different risk categories. A total of 256 HF patients were finally included and categorized into two groups based on their serum Drp1 levels, labeled as the low (Drp1 ≤2.66 ng/ml, n=101) and high group (Drp1 >2.66 ng/ml, n=155). Patients with low serum Drp1 concentrations showed impaired heart structure and function, as assessed by echocardiography. The 6‑month follow‑up results indicated that patients with reduced Drp1 concentrations faced a substantially increased risk of MACEs (21.1% vs. 2.8%; P<0.001). The present study revealed that diminished serum Drp1 concentrations could potentially act as a predictive marker for the prognosis of HF in a broad patient population.
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March-2024
Volume 27 Issue 3

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Spandidos Publications style
Cheng C, Fan Z, Ji M, Xu Y, He S and Ma G: Prognostic significance of serum dynamin‑related protein 1 in patients with heart failure: Findings from a prospective observational study. Exp Ther Med 27: 115, 2024
APA
Cheng, C., Fan, Z., Ji, M., Xu, Y., He, S., & Ma, G. (2024). Prognostic significance of serum dynamin‑related protein 1 in patients with heart failure: Findings from a prospective observational study. Experimental and Therapeutic Medicine, 27, 115. https://doi.org/10.3892/etm.2024.12404
MLA
Cheng, C., Fan, Z., Ji, M., Xu, Y., He, S., Ma, G."Prognostic significance of serum dynamin‑related protein 1 in patients with heart failure: Findings from a prospective observational study". Experimental and Therapeutic Medicine 27.3 (2024): 115.
Chicago
Cheng, C., Fan, Z., Ji, M., Xu, Y., He, S., Ma, G."Prognostic significance of serum dynamin‑related protein 1 in patients with heart failure: Findings from a prospective observational study". Experimental and Therapeutic Medicine 27, no. 3 (2024): 115. https://doi.org/10.3892/etm.2024.12404