Role and targeting of the AGC kinase family in pulmonary fibrosis (Review)

  • Authors:
    • Chao Mei
    • Tao Chen
    • Xiangfei Huang
    • Chenlu Xiong
    • Shibiao Chen
    • Yong Li
  • View Affiliations

  • Published online on: March 8, 2024     https://doi.org/10.3892/etm.2024.12478
  • Article Number: 190
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Abstract

Pulmonary fibrosis (PF) is a progressive and irreversible pulmonary disease with a high mortality rate and limited treatment options. The cAMP‑dependent protein kinase A, cGMP‑dependent protein kinase G and phospholipid‑dependent protein kinase C, collectively known as AGC kinases, are evolutionarily conserved protein kinases that are widely distributed among eukaryotes. AGC kinases serve a crucial role in a variety of cellular functions and pathological processes, including cancer, diabetes, inflammation and viral infections, where they have been implicated the pathogenesis of PF. The present review summarizes the evidence for the involvement of specific AGC kinases in the pathogenesis of PF, and provides a theoretical basis for the development of targeted AGC kinase small molecule inhibitors or targeted drugs, offering more effective treatment options and strategies for patients with PF.
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May-2024
Volume 27 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Mei C, Chen T, Huang X, Xiong C, Chen S and Li Y: Role and targeting of the AGC kinase family in pulmonary fibrosis (Review). Exp Ther Med 27: 190, 2024.
APA
Mei, C., Chen, T., Huang, X., Xiong, C., Chen, S., & Li, Y. (2024). Role and targeting of the AGC kinase family in pulmonary fibrosis (Review). Experimental and Therapeutic Medicine, 27, 190. https://doi.org/10.3892/etm.2024.12478
MLA
Mei, C., Chen, T., Huang, X., Xiong, C., Chen, S., Li, Y."Role and targeting of the AGC kinase family in pulmonary fibrosis (Review)". Experimental and Therapeutic Medicine 27.5 (2024): 190.
Chicago
Mei, C., Chen, T., Huang, X., Xiong, C., Chen, S., Li, Y."Role and targeting of the AGC kinase family in pulmonary fibrosis (Review)". Experimental and Therapeutic Medicine 27, no. 5 (2024): 190. https://doi.org/10.3892/etm.2024.12478