Open Access

Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis

  • Authors:
    • George Fotakopoulos
    • Vasiliki Epameinondas Georgakopoulou
    • Petros Papalexis
    • Demetrios A. Spandidos
    • Nikolaos Trakas
    • Pagona Sklapani
    • Kostas N. Fountas
  • View Affiliations

  • Published online on: March 20, 2024     https://doi.org/10.3892/etm.2024.12503
  • Article Number: 215
  • Copyright: © Fotakopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intracranial cavernous malformations (CMs) are vascular lesions with a high bleeding rate. At present, the debate regarding their treatment is still ongoing. The present systematic review and meta‑analysis aimed to evaluate the safety of surgery or radiosurgery (SRS) for the management of CMs and to determine their potential outcomes compared with conservative treatment. The present systematic review and meta‑analysis investigated the relative articles involving the management of intracranial CMs, namely their natural history (conservative treatment) vs. surgical/SRS treatment through electronic databases until June, 2023. The collected variables included the first author's name, the study period covered, the year of publication, the total number of patients examined and their age, and the number of males. In total, six articles met the eligibility criteria. The total number of patients was 399 (157 in the surgery/SRS group and 242 in the conservative treatment group). The results revealed that surgical or SRS management is a safe procedure for CMs compared with conservative treatment. Notably, the use of hemosiderin in the pre‑MRI, the free of seizures parameter and the neurological deficit parameters were associated with improved outcomes in the surgical or SRS group of patients.
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May-2024
Volume 27 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Fotakopoulos G, Georgakopoulou VE, Papalexis P, Spandidos DA, Trakas N, Sklapani P and Fountas KN: Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis. Exp Ther Med 27: 215, 2024.
APA
Fotakopoulos, G., Georgakopoulou, V.E., Papalexis, P., Spandidos, D.A., Trakas, N., Sklapani, P., & Fountas, K.N. (2024). Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 27, 215. https://doi.org/10.3892/etm.2024.12503
MLA
Fotakopoulos, G., Georgakopoulou, V. E., Papalexis, P., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 27.5 (2024): 215.
Chicago
Fotakopoulos, G., Georgakopoulou, V. E., Papalexis, P., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 27, no. 5 (2024): 215. https://doi.org/10.3892/etm.2024.12503