LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1
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- Published online on: December 3, 2024 https://doi.org/10.3892/etm.2024.12777
- Article Number: 27
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Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
There is increasing evidence that long non‑coding (lnc)RNA EGFR‑AS1 is involved in the development of numerous types of cancer, including non‑small‑cell lung cancer (NSCLC). The Cancer Genome Atlas (TCGA) demonstrates that EGFR‑AS1 is highly expressed in NSCLC. Downregulation of EGFR‑AS1 in A549 and PC9 NSCLC cells demonstrates inhibition of NSCLC proliferation, invasion and metastasis. The present study demonstrated that lncRNA EGFR‑AS1 was essential for the development of NSCLC through its function as a competitive endogenous RNA binding to miR‑449a and upregulating histone deacetylase 1. In brief, it identified a novel signaling pathway that mediated the invasion and metastasis of NSCLC and may therefore provide a new treatment target for NSCLC.
