Open Access

Successful conversion surgery following tislelizumab with chemotherapy in a patient with stage IIIC lung adenocarcinoma harboring RET fusions: A case report and review of the literature

  • Authors:
    • De-Hao Tu
    • Rirong Qu
    • Fang Wen
    • Qiang Zhou
    • Qianyun Liu
    • Lingmei Huang
    • Tao Chen
  • View Affiliations

  • Published online on: February 10, 2025     https://doi.org/10.3892/etm.2025.12820
  • Article Number: 70
  • Copyright: © Tu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immune checkpoint inhibitors (ICIs) have emerged as a beacon of hope for most patients with stage III non‑small cell lung cancer (NSCLC) who are no longer surgical candidates. However, the literature on the use of immunotherapy in patients with NSCLC with rearranged during transfection (RET) gene fusions is scant. The present study reports the case of a 61‑year‑old female patient, diagnosed with stage IIIC lung adenocarcinoma, exhibiting two RET gene fusions and high programmed death‑ligand 1 expression. Following four treatment cycles of tislelizumab in combination with pemetrexed and cisplatin, the patient was successfully downstaged, enabling radical surgery. The post‑operative pathology analysis indicated a major pathologic response. This case study contributes to the growing body of evidence supporting the use of ICIs in treating locally advanced NSCLC with RET gene fusions.
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April-2025
Volume 29 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tu D, Qu R, Wen F, Zhou Q, Liu Q, Huang L and Chen T: Successful conversion surgery following tislelizumab with chemotherapy in a patient with stage IIIC lung adenocarcinoma harboring RET fusions: A case report and review of the literature. Exp Ther Med 29: 70, 2025.
APA
Tu, D., Qu, R., Wen, F., Zhou, Q., Liu, Q., Huang, L., & Chen, T. (2025). Successful conversion surgery following tislelizumab with chemotherapy in a patient with stage IIIC lung adenocarcinoma harboring RET fusions: A case report and review of the literature. Experimental and Therapeutic Medicine, 29, 70. https://doi.org/10.3892/etm.2025.12820
MLA
Tu, D., Qu, R., Wen, F., Zhou, Q., Liu, Q., Huang, L., Chen, T."Successful conversion surgery following tislelizumab with chemotherapy in a patient with stage IIIC lung adenocarcinoma harboring RET fusions: A case report and review of the literature". Experimental and Therapeutic Medicine 29.4 (2025): 70.
Chicago
Tu, D., Qu, R., Wen, F., Zhou, Q., Liu, Q., Huang, L., Chen, T."Successful conversion surgery following tislelizumab with chemotherapy in a patient with stage IIIC lung adenocarcinoma harboring RET fusions: A case report and review of the literature". Experimental and Therapeutic Medicine 29, no. 4 (2025): 70. https://doi.org/10.3892/etm.2025.12820