Open Access

Aurora kinase A promotes epithelial‑mesenchymal transition by regulating P130 and P107 molecules in thyroid cancer cells

  • Authors:
    • Liyun Yang
    • Yuhuan Gao
    • Jing Lu
    • Geping Wu
  • View Affiliations

  • Published online on: March 12, 2025     https://doi.org/10.3892/etm.2025.12843
  • Article Number: 93
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The mortality associated with thyroid cancer (THCA) has been increasing due to distant metastasis, yet the precise mechanisms remain unclear. The present study examined the role of Aurora kinase A (AURKA) in THCA cells. Reducing AURKA expression led to decreased cell proliferation and inhibited the transition of BHT101 and BCPAP cells from the G0 phase to active division. Interestingly, decreasing AURKA expression also enhanced the cells' ability to move, migrate and invade. It was found that AURKA regulates key molecules involved in cell proliferation. Specifically, reducing AURKA expression increased the levels of P130 and E2F4, while decreasing the level of P107. Furthermore, upregulating AURKA promoted epithelial‑mesenchymal transition (EMT), whereas downregulating AURKA had the opposite effect. Blocking the focal adhesion kinase signaling pathway impaired the movement, migration and invasion capabilities of THCA cells, underscoring its crucial role in metastasis. In conclusion, AURKA promotes EMT by regulating P130 and P107, thereby facilitating the metastasis of THCA.
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May-2025
Volume 29 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yang L, Gao Y, Lu J and Wu G: Aurora kinase A promotes epithelial‑mesenchymal transition by regulating P130 and P107 molecules in thyroid cancer cells. Exp Ther Med 29: 93, 2025.
APA
Yang, L., Gao, Y., Lu, J., & Wu, G. (2025). Aurora kinase A promotes epithelial‑mesenchymal transition by regulating P130 and P107 molecules in thyroid cancer cells. Experimental and Therapeutic Medicine, 29, 93. https://doi.org/10.3892/etm.2025.12843
MLA
Yang, L., Gao, Y., Lu, J., Wu, G."Aurora kinase A promotes epithelial‑mesenchymal transition by regulating P130 and P107 molecules in thyroid cancer cells". Experimental and Therapeutic Medicine 29.5 (2025): 93.
Chicago
Yang, L., Gao, Y., Lu, J., Wu, G."Aurora kinase A promotes epithelial‑mesenchymal transition by regulating P130 and P107 molecules in thyroid cancer cells". Experimental and Therapeutic Medicine 29, no. 5 (2025): 93. https://doi.org/10.3892/etm.2025.12843