Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan

Gharaibeh,Mohammad Y.; Batayneh,Sajida; Khabour,Omar F.; Daoud,Azhar

doi:10.3892/etm_00000108

Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan

Authors:
- Mohammad Y. Gharaibeh
- Sajida Batayneh
- Omar F. Khabour
- Azhar Daoud
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Affiliations: Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan. younisgh@just.edu.jo
Published online on: July 1, 2010 https://doi.org/10.3892/etm_00000108
Pages: 701-705

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Abstract

Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders in children. In this study, the association between 10-repeats in the DAT1 gene and the (GT)n repeat in the DBH gene and ADHD was examined in children from Jordan. In addition, the levels of dopamine-β-hydroxylase enzyme activity in the plasma of ADHD children were evaluated. Fifty children with ADHD and 50 age- and gender-matched control subjects were recruited. The results showed significant differences between the ADHD group and controls with respect to the plasma levels of dopamine-β-hydroxylase enzyme activity (25.4±2.3 vs. 84.7±5.0 µmol/min; p<0.01). Moreover, the 10-repeat DAT1 gene and (GT)n DBH gene polymorphisms were significantly associated with ADHD development (p<0.05). In conclusion, the DBH and DAT1 genes appear to play a role in the development of ADHD in the Jordanian population.

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