Metabolism of D-glucose anomers in pancreatic islets (Review)
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- Published online on: December 1, 2003 https://doi.org/10.3892/ijmm.12.6.911
- Pages: 911-916
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Abstract
D-glucose metabolism displays anomeric specificity in pancreatic islets and other cell types. Recent studies have extended this knowledge to the effect of D-glucose to augment D-fructose phosphorylation by glucokinase in both pancreatic islet B-cells and hepatocytes, and have documented that the anomeric specificity of D-glucose metabolism in pancreatic islets implies enzyme-to-enzyme tunnelling of metabolites in the early steps of glycolysis. It is proposed that the anomeric specificity of D-glucose metabolism is essential to a sound understanding of carbohydrate homeostasis in health and disease.
