Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family

  • Authors:
    • Kerstin Reimers
    • Claudia Y.-U. Choi
    • Eddy Mau-Thek
    • Peter M. Vogt
  • View Affiliations

  • Published online on: October 1, 2006     https://doi.org/10.3892/ijmm.18.4.729
  • Pages: 729-734
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Abstract

Cellular sensitivity to apoptotic stimuli is determined by several regulatory proteins. The biological and biomedical impact of these regulatory proteins is of fundamental importance for understanding and controlling apoptotic processes. We used a bioinformatic approach to characterise the antiapoptotic protein Lifeguard (LFG). LFG is an evolutionarily well-conserved protein with homologues in many species. Due to its hydrophobic nature it is predicted to reside in cellular membranes, namely the endoplasmatic reticulum and the plasma membrane, with seven transmembrane spanners and a small cytoplasmic domain. The consensus motif of a protein family with unknown function UPF0005 was found in the C-terminus. The structure of Lifeguard resembles the antiapoptotic protein Bax Inhibitor-1 (BI-1). Concordantly, it was shown that Bax co-immunoprecipitates with LFG. Our results indicate that LFG belongs to a new cytoprotective family with evolutionarily conserved functions in the prevention of programmed cell death.

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October 2006
Volume 18 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Reimers K, Choi CY, Mau-Thek E and Vogt PM: Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family. Int J Mol Med 18: 729-734, 2006.
APA
Reimers, K., Choi, C.Y., Mau-Thek, E., & Vogt, P.M. (2006). Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family. International Journal of Molecular Medicine, 18, 729-734. https://doi.org/10.3892/ijmm.18.4.729
MLA
Reimers, K., Choi, C. Y., Mau-Thek, E., Vogt, P. M."Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family". International Journal of Molecular Medicine 18.4 (2006): 729-734.
Chicago
Reimers, K., Choi, C. Y., Mau-Thek, E., Vogt, P. M."Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family". International Journal of Molecular Medicine 18, no. 4 (2006): 729-734. https://doi.org/10.3892/ijmm.18.4.729