Paracrine control of glucagon release by somatostatin (Review)

Malaisse,Willy J.

doi:10.3892/ijmm.2013.1605

Paracrine control of glucagon release by somatostatin (Review)

Authors:
- Willy J. Malaisse
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Affiliations: Department of Biochemistry, Université Libre de Bruxelles, B-1070 Brussels, Belgium
Published online on: December 24, 2013 https://doi.org/10.3892/ijmm.2013.1605
Pages: 491-498

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Abstract

Emphasis was recently placed on the modulation of glucagon secretion attributable to a paracrine effect of somatostatin. This review draws attention to prior findings related to such a view. The effects of nutrient secretagogues upon insulin, somatostatin and glucagon release by the perfused pancreas are first considered. Three examples of paradoxical secretory responses of insulin- and glucagon-producing cells are then given. Further experiments dealing with the possible role of somatostatin upon glucagon release and the relevance of pancreatic compartmentation are also presented. It is concluded that these prior findings provide, within limits, support to the postulated paracrine role of somatostatin in the control of glucagon secretion.

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