Open Access

The molecular basis of fertilization (Review)

  • Authors:
    • Katerina Georgadaki
    • Nikolas Khoury
    • Demetrios A. Spandidos
    • Vasilis Zoumpourlis
  • View Affiliations

  • Published online on: August 31, 2016     https://doi.org/10.3892/ijmm.2016.2723
  • Pages: 979-986
  • Copyright: © Georgadaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fertilization is the fusion of the male and female gamete. The process involves the fusion of an oocyte with a sperm, creating a single diploid cell, the zygote, from which a new individual organism will develop. The elucidation of the molecular mechanisms of fertilization has fascinated researchers for many years. In this review, we focus on this intriguing process at the molecular level. Several molecules have been identified to play a key role in each step of this intriguing process (the sperm attraction from the oocyte, the sperm maturation, the sperm and oocyte fusion and the two gamete pronuclei fusion leading to the zygote). Understanding the molecular mechanisms of the cell‑cell interactions will provide a better understanding of the causes of fertility issues due to fertilization defects.
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October-2016
Volume 38 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Georgadaki K, Khoury N, Spandidos DA and Zoumpourlis V: The molecular basis of fertilization (Review). Int J Mol Med 38: 979-986, 2016.
APA
Georgadaki, K., Khoury, N., Spandidos, D.A., & Zoumpourlis, V. (2016). The molecular basis of fertilization (Review). International Journal of Molecular Medicine, 38, 979-986. https://doi.org/10.3892/ijmm.2016.2723
MLA
Georgadaki, K., Khoury, N., Spandidos, D. A., Zoumpourlis, V."The molecular basis of fertilization (Review)". International Journal of Molecular Medicine 38.4 (2016): 979-986.
Chicago
Georgadaki, K., Khoury, N., Spandidos, D. A., Zoumpourlis, V."The molecular basis of fertilization (Review)". International Journal of Molecular Medicine 38, no. 4 (2016): 979-986. https://doi.org/10.3892/ijmm.2016.2723