Open Access

Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)

  • Authors:
    • Xianliang Dai
    • Li Hua
    • Yihong Chen
    • Jiamei Wang
    • Jingyi Li
    • Feng Wu
    • Yanda Zhang
    • Jiyuan Su
    • Zonggui Wu
    • Chun Liang
  • View Affiliations

  • Published online on: March 30, 2018     https://doi.org/10.3892/ijmm.2018.3605
  • Pages: 3-12
  • Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A variety of cells and cytokines have been shown to be involved in the whole process of hypertension. Data from experimental and clinical studies on hypertension have confirmed the key roles of immune cells and inflammation in the process. Dysfunction of the thymus, which modulates the development and maturation of lymphocytes, has been shown to be associated with the severity of hypertension. Furthermore, gradual atrophy, functional decline or loss of the thymus has been revealed to be associated with aging. The restoration or enhancement of thymus function via upregulation in the expression of thymus transcription factors forkhead box N1 or thymus transplantation may provide an option to halt or reverse the pathological process of hypertension. Therefore, the thymus may be key in hypertension and associated target organ damage, and may provide a novel treatment strategy for the clinical management of patients with hypertension in addition to different commercial drugs. The purpose of this review is to summarize and discuss the advances in our understanding of the impact of thymus function on hypertension from data from animal and human studies, and the potential mechanisms.
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July-2018
Volume 42 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Dai X, Hua L, Chen Y, Wang J, Li J, Wu F, Zhang Y, Su J, Wu Z, Liang C, Liang C, et al: Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review). Int J Mol Med 42: 3-12, 2018.
APA
Dai, X., Hua, L., Chen, Y., Wang, J., Li, J., Wu, F. ... Liang, C. (2018). Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review). International Journal of Molecular Medicine, 42, 3-12. https://doi.org/10.3892/ijmm.2018.3605
MLA
Dai, X., Hua, L., Chen, Y., Wang, J., Li, J., Wu, F., Zhang, Y., Su, J., Wu, Z., Liang, C."Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)". International Journal of Molecular Medicine 42.1 (2018): 3-12.
Chicago
Dai, X., Hua, L., Chen, Y., Wang, J., Li, J., Wu, F., Zhang, Y., Su, J., Wu, Z., Liang, C."Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)". International Journal of Molecular Medicine 42, no. 1 (2018): 3-12. https://doi.org/10.3892/ijmm.2018.3605