Open Access

lncRNA KCNQ1OT1 promotes proliferation and invasion of glioma cells by targeting the miR‑375/YAP pathway

Retraction in: /10.3892/ijmm.2022.5170

  • Authors:
    • Panfeng Ding
    • Bo Liang
    • Jixin Shou
    • Xinjun Wang
  • View Affiliations

  • Published online on: October 19, 2020     https://doi.org/10.3892/ijmm.2020.4760
  • Pages: 1983-1992
  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The long non‑coding RNA KCNQ1OT1 is generally recognized as an oncogenic molecule in several human malignant tumors. However, to the best of our knowledge, the role of KCNQ1OT1 in glioma has not been fully investigated. The current study aimed to probe the biological function of KCNQ1OT1 in human glioma cell lines and its mechanisms. The glioma cell lines U251 and U87‑MG were used as cell models. Cell proliferation and apoptosis assays were used to measure the effects of different treatments on survival, and reverse transcription‑quantitative PCR and western blotting were used to investigate the expression profiles of key molecules. Migration and invasion assays were conducted to reveal the biological features of glioma cells. The results indicated that KCNQ1OT1 was upregulated in glioma tissues compared with adjacent tissues, which was associated with poor prognosis. Additionally, knockdown of KCNQ1OT1 in U251 and U87‑MG cells inhibited cell proliferation, migration and invasion, but had no effect on apoptosis. The effects of KCNQ1OT1 on migration and invasion were partially attributed to enhanced Yes‑associated protein (YAP) expression levels and epithelial‑mesenchymal transition (EMT) signaling. Furthermore, microRNA (miR)‑375 functioned as a link between KCNQ1OT1 and YAP in regulating cell proliferation. Finally, the KCNQ1OT1/miR‑375/YAP axis modulated cell proliferation and cell fate by affecting the modulated YAP‑mediated EMT signaling. In conclusion, the KCNQ1OT1/miR‑375/YAP axis modulated migration and invasion of glioma cells by affecting EMT signaling; thus, targeting KCNQ1OT1 may represent a promising strategy in glioma therapeutics.
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December-2020
Volume 46 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Ding P, Liang B, Shou J and Wang X: lncRNA KCNQ1OT1 promotes proliferation and invasion of glioma cells by targeting the miR‑375/YAP pathway Retraction in /10.3892/ijmm.2022.5170. Int J Mol Med 46: 1983-1992, 2020.
APA
Ding, P., Liang, B., Shou, J., & Wang, X. (2020). lncRNA KCNQ1OT1 promotes proliferation and invasion of glioma cells by targeting the miR‑375/YAP pathway Retraction in /10.3892/ijmm.2022.5170. International Journal of Molecular Medicine, 46, 1983-1992. https://doi.org/10.3892/ijmm.2020.4760
MLA
Ding, P., Liang, B., Shou, J., Wang, X."lncRNA KCNQ1OT1 promotes proliferation and invasion of glioma cells by targeting the miR‑375/YAP pathway Retraction in /10.3892/ijmm.2022.5170". International Journal of Molecular Medicine 46.6 (2020): 1983-1992.
Chicago
Ding, P., Liang, B., Shou, J., Wang, X."lncRNA KCNQ1OT1 promotes proliferation and invasion of glioma cells by targeting the miR‑375/YAP pathway Retraction in /10.3892/ijmm.2022.5170". International Journal of Molecular Medicine 46, no. 6 (2020): 1983-1992. https://doi.org/10.3892/ijmm.2020.4760