BCL2‑regulated apoptotic process in myocardial ischemia‑reperfusion injury (Review)

Korshunova,Anna Yu.; Blagonravov,Mikhail L.; Neborak,Ekaterina V.; Syatkin,Sergey P.; Sklifasovskaya,Anastasia P.; Semyatov,Said M.; Agostinelli,Enzo

doi:10.3892/ijmm.2020.4781

BCL2‑regulated apoptotic process in myocardial ischemia‑reperfusion injury (Review)

Authors:
- Anna Yu. Korshunova
- Mikhail L. Blagonravov
- Ekaterina V. Neborak
- Sergey P. Syatkin
- Anastasia P. Sklifasovskaya
- Said M. Semyatov
- Enzo Agostinelli
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Affiliations: Department of Pathophysiology, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation, Department of Biochemistry, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation, Department of Obstetrics and Gynecology with the Course of Perinatology, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation, Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, University Hospital Policlinico Umberto I, I‑00161 Rome, Italy
Published online on: November 4, 2020 https://doi.org/10.3892/ijmm.2020.4781
Pages: 23-36
Copyright: © Korshunova et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The leading cause of death in developed countries is cardiovascular disease, where coronary heart disease is the main cause of death. Myocardial reperfusion is the most significant method to prevent cell death after ischemia. However, restoration of blood flow may paradoxically lead to myocardial ischemia‑reperfusion injury (MI/RI) accompanied by metabolic disturbances and cardiomyocyte death. As the myocardium has an extremely limited ability to regenerate, the mechanisms of regulated cell death, including apoptosis, are the most significant for contemporary research due to their reversibility. BCL2 is a key anti‑apoptotic protein. There are several signaling pathways and compounds regulating BCL2, including PI3K/AKT and MEK1/ERK1/2, JAK2/STAT3, endothelial nitric oxide synthase, PTEN, cardiac ankyrin repeat protein and microRNA, which can serve as targets for modern methods of cardioprotective therapy inhibiting intrinsic apoptosis and saving viable cardiomyocytes after MI/RI. The present review considers the mechanisms of Bcl2‑regulated apoptosis in the development and treatment of MI/RI.

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