Open Access

Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (Review)

  • Authors:
    • Ruiying Wang
    • Min Wang
    • Jingxue Ye
    • Guibo Sun
    • Xiaobo Sun
  • View Affiliations

  • Published online on: November 24, 2020     https://doi.org/10.3892/ijmm.2020.4798
  • Pages: 65-76
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Atherosclerosis (AS) is a chronic disease with a complex pathology that may lead to several cardiovascular and cerebrovascular diseases; however, further research is necessary to fully elucidate its pathogenesis. The main risk factors for AS include lipid metabolism disorders, endothelial cell injury, inflammation and immune dysfunction, among which vascular endothelial cell damage is considered as the main trigger for AS occurrence and development. Endothelial cell damage leads to enhanced intimal permeability and leukocyte adhesion, promoting thrombus formation and accelerating disease progression. The function of endothelial cells is affected by glycolysis regulation, since 80% of ATP in these cells is produced via this pathway. Genes associated with AS and endothelial cell glycolysis, including AKT1, interleukin‑6, vascular endothelial growth factor A, TP53, signal transducer and activator of transcription 3, SRC and mitogen‑activated protein kinase 1, were screened. Through integrated analysis, these genes were found to play a key role in AS by regulating multiple signaling pathways associated with cell signal transduction, energy metabolism, immune function and thrombosis. In conclusion, endothelial cell injury in AS may be alleviated by glycolysis and is a potential clinical treatment strategy for AS.
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January-2021
Volume 47 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Wang R, Wang M, Ye J, Sun G and Sun X: Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (Review). Int J Mol Med 47: 65-76, 2021.
APA
Wang, R., Wang, M., Ye, J., Sun, G., & Sun, X. (2021). Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (Review). International Journal of Molecular Medicine, 47, 65-76. https://doi.org/10.3892/ijmm.2020.4798
MLA
Wang, R., Wang, M., Ye, J., Sun, G., Sun, X."Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (Review)". International Journal of Molecular Medicine 47.1 (2021): 65-76.
Chicago
Wang, R., Wang, M., Ye, J., Sun, G., Sun, X."Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (Review)". International Journal of Molecular Medicine 47, no. 1 (2021): 65-76. https://doi.org/10.3892/ijmm.2020.4798