Role of emerging vitamin K‑dependent proteins: Growth arrest‑specific protein 6, Gla‑rich protein and periostin (Review)
- Authors:
- Huiyu Xiao
- Jiepeng Chen
- Lili Duan
- Shuzhuang Li
-
Affiliations: Department of Physiology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Sungen Bioscience Co., Ltd., Shantou, Guangdong 515071, P.R. China - Published online on: December 29, 2020 https://doi.org/10.3892/ijmm.2020.4835
- Article Number: 2
-
Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Dam H: The antihaemorrhagic vitamin of the chick. Biochem J. 29:1273–1285. 1935. View Article : Google Scholar : PubMed/NCBI | |
Palmer CR, Blekkenhorst LC, Lewis JR, Ward NC, Schultz CJ, Hodgson JM, Croft KD and Sim M: Quantifying dietary vitamin K and its link to cardiovascular health: A narrative review. Food Funct. 11:2826–2837. 2020. View Article : Google Scholar : PubMed/NCBI | |
Hirota Y, Tsugawa N, Nakagawa K, Suhara Y, Tanaka K, Uchino Y, Takeuchi A, Sawada N, Kamao M, Wada A, et al: Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. J Biol Chem. 288:33071–33080. 2013. View Article : Google Scholar : PubMed/NCBI | |
Simes DC, Viegas CSB, Araújo N and Marreiros C: Vitamin K as a diet supplement with impact in human health: Current evidence in age-related diseases. Nutrients. 12:1382020. View Article : Google Scholar : | |
Mirza F and Canalis E: Management of endocrine disease: Secondary osteoporosis: Pathophysiology and management. Eur J Endocrinol. 173:R131–R151. 2015. View Article : Google Scholar : PubMed/NCBI | |
Cheung CL, Ang SB, Chadha M, Chow ES, Chung YS, Hew FL, Jaisamrarn U, Ng H, Takeuchi Y, Wu CH, et al: An updated hip fracture projection in Asia: The Asian federation of osteoporosis societies study. Osteoporos Sarcopenia. 4:16–21. 2018. View Article : Google Scholar | |
Wasilewski GB, Vervloet MG and Schurgers LJ: The bone-vasculature axis: Calcium supplementation and the role of vitamin K. Front Cardiovasc Med. 6:62019. View Article : Google Scholar : PubMed/NCBI | |
Danziger J, Young RL, Shea MK, Tracy RP, Ix JH, Jenny NS and Mukamal KJ: Vitamin K-dependent protein activity and incident ischemic cardiovascular disease: The multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 36:1037–1042. 2016. View Article : Google Scholar : PubMed/NCBI | |
Iribarren C, Sidney S, Sternfeld B and Browner WS: Calcification of the aortic arch: Risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. JAMA. 283:2810–2815. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kondos GT, Hoff JA, Sevrukov A, Daviglus ML, Garside DB, Devries SS, Chomka EV and Liu K: Electron-beam tomography coronary artery calcium and cardiac events: A 37-month follow-up of 5635 initially asymptomatic low- to intermediate-risk adults. Circulation. 107:2571–2576. 2003. View Article : Google Scholar : PubMed/NCBI | |
Ferland G: The discovery of vitamin K and its clinical applications. Ann Nutr Metab. 61:213–218. 2012. View Article : Google Scholar : PubMed/NCBI | |
Cheung CL, Sahni S, Cheung BM, Sing CW and Wong IC: Vitamin K intake and mortality in people with chronic kidney disease from NHANES III. Clin Nutr. 34:235–240. 2015. View Article : Google Scholar | |
Fusaro M, Plebani M, Iervasi G and Gallieni M: Vitamin K deficiency in chronic kidney disease: Evidence is building up. Am J Nephrol. 45:1–3. 2017. View Article : Google Scholar | |
Turner ME, Adams MA and Holden RM: The vitamin K metabolome in chronic kidney disease. Nutrients. 10:10762018. View Article : Google Scholar : | |
Kaesler N, Magdeleyns E, Herfs M, Schettgen T, Brandenburg V, Fliser D, Vermeer C, Floege J, Schlieper G and Krüger T: Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation. Kidney Int. 86:286–293. 2014. View Article : Google Scholar : PubMed/NCBI | |
Di Lullo L, House A, Gorini A, Santoboni A, Russo D and Ronco C: Chronic kidney disease and cardiovascular complications. Heart Fail Rev. 20:259–272. 2015. View Article : Google Scholar | |
Shearer MJ, Mallinson CN, Webster GR and Barkhan P: Clearance from plasma and excretion in urine, faeces and bile of an intravenous dose of tritiated vitamin K 1 in man. Br J Haematol. 22:579–588. 1972. View Article : Google Scholar : PubMed/NCBI | |
Schurgers LJ, Teunissen KJF, Hamulyák K, Knapen MH, Vik H and Vermeer C: Vitamin K-containing dietary supplements: Comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 109:3279–3283. 2007. View Article : Google Scholar | |
Halder M, Petsophonsakul P, Akbulut AC, Pavlic A, Bohan F, Anderson E, Maresz K, Kramann R and Schurgers L: Vitamin K: Double bonds beyond coagulation insights into differences between vitamin K1 and K2 in health and disease. Int J Mol Sci. 20:8962019. View Article : Google Scholar : | |
Willems BAG, Vermeer C, Reutelingsperger CP and Schurgers LJ: The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification. Mol Nutr Food Res. 58:1620–1635. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kearon C, Akl EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, Nelson ME, Wells PS, Gould MK, Dentali F, et al: Antithrombotic therapy for VTE disease: Antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 141(2 Suppl): e419S–e496S. 2012. View Article : Google Scholar : PubMed/NCBI | |
Tie JK and Stafford DW: Structural and functional insights into enzymes of the vitamin K cycle. J Thromb Haemost. 14:236–247. 2016. View Article : Google Scholar : | |
Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B and Furie BC: Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol. 10:751–756. 2003. View Article : Google Scholar : PubMed/NCBI | |
Girolami A, Ferrari S, Cosi E, Santarossa C and Randi ML: Vitamin K-dependent coagulation factors that may be responsible for both bleeding and thrombosis (FII, FVII, and FIX). Clin Appl Thromb Hemost. 24(9 Suppl): 42S–47S. 2018. View Article : Google Scholar : PubMed/NCBI | |
Mahdi AJ, Obaji SG and Collins PW: Role of enhanced half-life factor VIII and IX in the treatment of haemophilia. Br J Haematol. 169:768–776. 2015. View Article : Google Scholar : PubMed/NCBI | |
Muller MP, Wang Y, Morrissey JH and Tajkhorshid E: Lipid specificity of the membrane binding domain of coagulation factor X. J Thromb Haemost. 15:2005–2016. 2017. View Article : Google Scholar : PubMed/NCBI | |
Rezaie AR: Regulation of the protein C anticoagulant and antiinflammatory pathways. Curr Med Chem. 17:2059–2069. 2010. View Article : Google Scholar : PubMed/NCBI | |
Mosnier LO, Zlokovic BV and Griffin JH: The cytoprotective protein C pathway. Blood. 109:3161–3172. 2007. View Article : Google Scholar | |
Mosnier LO and Griffin JH: Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities. Front Biosci. 11:2381–2399. 2006. View Article : Google Scholar : PubMed/NCBI | |
Majid Z, Tahir F, Ahmed J, Bin Arif T and Haq A: Protein C deficiency as a risk factor for stroke in young adults: A review. Cureus. 12:e74722020.PubMed/NCBI | |
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 344:699–709. 2001. View Article : Google Scholar : PubMed/NCBI | |
Dahlbäck B: Vitamin K-dependent protein S: Beyond the protein C pathway. Semin Thromb Hemost. 44:176–184. 2018. View Article : Google Scholar | |
Suleiman L, Négrier C and Boukerche H: Protein S: A multi-functional anticoagulant vitamin K-dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer. Crit Rev Oncol Hematol. 88:637–654. 2013. View Article : Google Scholar : PubMed/NCBI | |
Fricke DR, Chatterjee S and Majumder R: Protein S in preventing thrombosis. Aging (Albany NY). 11:847–848. 2019. View Article : Google Scholar | |
Yasuma T, Yano Y, D'Alessandro-Gabazza CN, Toda M, Gil-Bernabe P, Kobayashi T, Nishihama K, Hinneh JA, Mifuji-Moroka R, Roeen Z, et al: Amelioration of diabetes by protein S. Diabetes. 65:1940–1951. 2016. View Article : Google Scholar : PubMed/NCBI | |
Topalidou M, Effraimidou S, Farmakiotis D, Papadakis E, Papaioannou G, Korantzis I and Garipidou V: Low protein Z levels, but not the intron F G79A polymorphism, are associated with unexplained pregnancy loss. Thromb Res. 124:24–27. 2009. View Article : Google Scholar | |
Ghozlan MF, Mohamed AAE, Eissa DS and Eldawy HS: Low protein Z level: A thrombophilic risk biomarker for acute coronary syndrome. Indian J Hematol Blood Transfus. 35:339–346. 2019. View Article : Google Scholar : PubMed/NCBI | |
Kulman JD, Harris JE, Haldeman BA and Davie EW: Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins. Proc Natl Acad Sci USA. 94:9058–9062. 1997. View Article : Google Scholar : PubMed/NCBI | |
Kulman JD, Harris JE, Xie L and Davie EW: Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein. Proc Natl Acad Sci USA. 104:8767–8772. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kulman JD, Harris JE, Xie L and Davie EW: Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. Proc Natl Acad Sci USA. 98:1370–1375. 2001. View Article : Google Scholar : PubMed/NCBI | |
Iwamoto J: Vitamin K2 therapy for postmenopausal osteoporosis. Nutrients. 6:1971–1980. 2014. View Article : Google Scholar : PubMed/NCBI | |
Mizokami A, Kawakubo-Yasukochi T and Hirata M: Osteocalcin and its endocrine functions. Biochem Pharmacol. 132:1–8. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wen L, Chen J, Duan L and Li S: Vitamin K-dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep. 18:3–15. 2018.PubMed/NCBI | |
Naito K, Watari T, Obayashi O, Katsube S, Nagaoka I and Kaneko K: Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis. Int J Mol Med. 29:756–760. 2012.PubMed/NCBI | |
Sweatt A, Sane DC, Hutson SM and Wallin R: Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats. J Thromb Haemost. 1:178–185. 2003. View Article : Google Scholar : PubMed/NCBI | |
Yao Y, Zebboudj AF, Shao E, Perez M and Boström K: Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1. J Biol Chem. 281:33921–33930. 2006. View Article : Google Scholar : PubMed/NCBI | |
Roy ME and Nishimoto SK: Matrix Gla protein binding to hydroxyapatite is dependent on the ionic environment: Calcium enhances binding affinity but phosphate and magnesium decrease affinity. Bone. 31:296–302. 2002. View Article : Google Scholar : PubMed/NCBI | |
Zuo PY, Chen XL, Lei YH, Liu CY and Liu YW: Growth arrest-specific gene 6 protein promotes the proliferation and migration of endothelial progenitor cells through the PI3K/AKT signaling pathway. Int J Mol Med. 34:299–306. 2014. View Article : Google Scholar : PubMed/NCBI | |
Qiu C, Zheng H, Tao H, Yu W, Jiang X, Li A, Jin H, Lv A and Li H: Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway. Mol Cell Biochem. 433:149–159. 2017. View Article : Google Scholar : PubMed/NCBI | |
Jiang X, Tao H, Qiu C, Ma X, Li S, Guo X, Lv A and Li H: Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. Eur J Pharmacol. 786:10–18. 2016. View Article : Google Scholar : PubMed/NCBI | |
Kawamoto A, Tkebuchava T, Yamaguchi J, Nishimura H, Yoon YS, Milliken C, Uchida S, Masuo O, Iwaguro H, Ma H, et al: Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation. 107:461–468. 2003. View Article : Google Scholar : PubMed/NCBI | |
Jiang L, Liu CY, Yang QF, Wang P and Zhang W: Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. Am J Clin Pathol. 131:738–743. 2009. View Article : Google Scholar : PubMed/NCBI | |
Chen LW, Chen W, Hu ZQ, Bian JL, Ying L, Hong GL, Qiu QM, Zhao GJ and Lu ZQ: Protective effects of growth arrest-specific protein 6 (Gas6) on sepsis-induced acute kidney injury. Inflammation. 39:575–582. 2016. View Article : Google Scholar | |
Novitskiy SV, Zaynagetdinov R, Vasiukov G, Gutor S, Han W, Serezani A, Matafonov A, Gleaves LA, Sherrill TP, Polosukhin VV and Blackwell TS: Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis. Oncotarget. 10:7031–7042. 2019. View Article : Google Scholar | |
Eitzinger N, Surmann-Schmitt C, Bösl M, Schett G, Engelke K, Hess A, von der Mark K and Stock M: Ucma is not necessary for normal development of the mouse skeleton. Bone. 50:670–680. 2012. View Article : Google Scholar | |
Stock M, Menges S, Eitzinger N, Geßlein M, Botschner R, Wormser L, Distler A, Schlötzer-Schrehardt U, Dietel K, Distler J, et al: A dual role of upper zone of growth plate and cartilage matrix-associated protein in human and mouse osteoarthritic cartilage: Inhibition of aggrecanases and promotion of bone turnover. Arthritis Rheumatol. 69:1233–1245. 2017. View Article : Google Scholar : PubMed/NCBI | |
Seuffert F, Weidner D, Baum W, Schett G and Stock M: Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis. Arthritis Res Ther. 20:882018. View Article : Google Scholar : PubMed/NCBI | |
Cavaco S, Viegas CS, Rafael MS, Ramos A, Magalhães J, Blanco FJ, Vermeer C and Simes DC: Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cell Mol Life Sci. 73:1051–1065. 2016. View Article : Google Scholar | |
Viegas CS, Cavaco S, Neves PL, Ferreira A, João A, Williamson MK, Price PA, Cancela ML and Simes DC: Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications. Am J Pathol. 175:2288–2298. 2009. View Article : Google Scholar : PubMed/NCBI | |
Lee YJ, Park SY, Lee SJ, Boo YC, Choi JY and Kim JE: Ucma, a direct transcriptional target of Runx2 and Osterix, promotes osteoblast differentiation and nodule formation. Osteoarthritis Cartilage. 23:1421–1431. 2015. View Article : Google Scholar : PubMed/NCBI | |
O'Grady S and Morgan MP: Microcalcifications in breast cancer: From pathophysiology to diagnosis and prognosis. Biochim Biophys Acta Rev Cancer. 1869:310–320. 2018. View Article : Google Scholar : PubMed/NCBI | |
Lee SH, Lee YJ, Park SI and Kim JE: Unique cartilage matrix-associated protein inhibits the migratory and invasive potential of triple-negative breast cancer. Biochem Biophys Res Commun. 530:680–685. 2020. View Article : Google Scholar : PubMed/NCBI | |
Duchamp de Lageneste O, Julien A, Abou-Khalil R, Frangi G, Carvalho C, Cagnard N, Cordier C, Conway SJ and Colnot C: Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nat Commun. 9:7732018. View Article : Google Scholar : PubMed/NCBI | |
Zhu S, Barbe MF, Liu C, Hadjiargyrou M, Popoff SN, Rani S, Safadi FF and Litvin J: Periostin-like-factor in osteogenesis. J Cell Physiol. 218:584–592. 2009. View Article : Google Scholar | |
Cobo T, Viloria CG, Solares L, Fontanil T, González-Chamorro E, De Carlos F, Cobo J, Cal S and Obaya AJ: Role of periostin in adhesion and migration of bone remodeling cells. PLoS One. 11:e01478372016. View Article : Google Scholar : PubMed/NCBI | |
Heo SC, Shin WC, Lee MJ, Kim BR, Jang IH, Choi EJ, Lee JS and Kim JH: Periostin accelerates bone healing mediated by human mesenchymal stem cell-embedded hydroxyapatite/tricalcium phosphate scaffold. PLoS One. 10:e01166982015. View Article : Google Scholar : PubMed/NCBI | |
Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, J Lin SC, Aronow BJ and Tallquist MD: Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nat Commun. 7:122602016. View Article : Google Scholar : PubMed/NCBI | |
Kaur H, Takefuji M, Ngai CY, Carvalho J, Bayer J, Wietelmann A, Poetsch A, Hoelper S, Conway SJ, Möllmann H, et al: Targeted ablation of periostin-expressing activated fibroblasts prevents adverse cardiac remodeling in mice. Circ Res. 118:1906–1917. 2016. View Article : Google Scholar : PubMed/NCBI | |
Taniyama Y, Katsuragi N, Sanada F, Azuma J, Iekushi K, Koibuchi N, Okayama K, Ikeda-Iwabu Y, Muratsu J, Otsu R, et al: Selective blockade of periostin exon 17 preserves cardiac performance in acute myocardial infarction. Hypertension. 67:356–361. 2016. View Article : Google Scholar | |
Izuhara K, Conway SJ, Moore BB, Matsumoto H, Holweg CT, Matthews JG and Arron JR: Roles of periostin in respiratory disorders. Am J Respir Crit Care Med. 193:949–956. 2016. View Article : Google Scholar : PubMed/NCBI | |
James A, Janson C, Malinovschi A, Holweg C, Alving K, Ono J, Ohta S, Ek A, Middelveld R, Dahlén B, et al: Serum periostin relates to type-2 inflammation and lung function in asthma: Data from the large population-based cohort Swedish GA(2)LEN. Allergy. 72:1753–1760. 2017. View Article : Google Scholar : PubMed/NCBI | |
Litvin J, Blagg A, Mu A, Matiwala S, Montgomery M, Berretta R, Houser S and Margulies K: Periostin and periostin-like factor in the human heart: Possible therapeutic targets. Cardiovasc Pathol. 15:24–32. 2006. View Article : Google Scholar : PubMed/NCBI | |
Zoch ML, Clemens TL and Riddle RC: New insights into the biology of osteocalcin. Bone. 82:42–49. 2016. View Article : Google Scholar | |
Cagman Z, Bingol Ozakpinar O, Cirakli Z, Gedikbasi A, Ay P, Colantonio D, Uras AR, Adeli K and Uras F: Reference intervals for growth arrest-specific 6 protein in adults. Scand J Clin Lab Invest. 77:109–114. 2017. View Article : Google Scholar : PubMed/NCBI | |
Varnum BC, Young C, Elliott G, Garcia A, Bartley TD, Fridell YW, Hunt RW, Trail G, Clogston C, Toso RJ, et al: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature. 373:623–626. 1995. View Article : Google Scholar : PubMed/NCBI | |
Li M, Ye J, Zhao G, Hong G, Hu X, Cao K, Wu Y and Lu Z: Gas6 attenuates lipopolysaccharide-induced TNF-α expression and apoptosis in H9C2 cells through NF-κB and MAPK inhibition via the Axl/PI3K/Akt pathway. Int J Mol Med. 44:982–994. 2019.PubMed/NCBI | |
Tanabe K, Nagata K, Ohashi K, Nakano T, Arita H and Mizuno K: Roles of gamma-carboxylation and a sex hormone-binding globulin-like domain in receptor-binding and in biological activities of Gas6. FEBS Lett. 408:306–310. 1997. View Article : Google Scholar : PubMed/NCBI | |
Bellido-Martín L and de Frutos PG: Vitamin K-dependent actions of Gas6. Vitam Horm. 78:185–209. 2008. View Article : Google Scholar : PubMed/NCBI | |
Wu G, Ma Z, Cheng Y, Hu W, Deng C, Jiang S, Li T, Chen F and Yang Y: Targeting Gas6/TAM in cancer cells and tumor microenvironment. Mol Cancer. 17:202018. View Article : Google Scholar : PubMed/NCBI | |
Melaragno MG, Cavet ME, Yan C, Tai LK, Jin ZG, Haendeler J and Berk BC: Gas6 inhibits apoptosis in vascular smooth muscle: Role of Axl kinase and Akt. J Mol Cell Cardiol. 37:881–887. 2004. View Article : Google Scholar : PubMed/NCBI | |
McCloskey P, Fridell YW, Attar E, Villa J, Jin Y, Varnum B and Liu ET: GAS6 mediates adhesion of cells expressing the receptor tyrosine kinase Axl. J Biol Chem. 272:23285–23291. 1997. View Article : Google Scholar : PubMed/NCBI | |
Stenhoff J, Dahlbäck B and Hafizi S: Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts. Biochem Biophys Res Commun. 319:871–878. 2004. View Article : Google Scholar : PubMed/NCBI | |
Rizzoni D, Rizzoni M, Nardin M, Chiarini G, Agabiti-Rosei C, Aggiusti C, Paini A, Salvetti M and Muiesan ML: Vascular aging and disease of the small vessels. High Blood Press Cardiovasc Prev. 26:183–189. 2019. View Article : Google Scholar : PubMed/NCBI | |
Jin CW, Wang H, Chen YQ, Tang MX, Fan GQ, Wang ZH, Li L, Zhang Y, Zhang W and Zhong M: Gas6 delays senescence in vascular smooth muscle cells through the PI3K/Akt/FoxO signaling pathway. Cell Physiol Biochem. 35:1151–1166. 2015. View Article : Google Scholar | |
Clauser S, Meilhac O, Bièche I, Raynal P, Bruneval P, Michel JB and Borgel D: Increased secretion of Gas6 by smooth muscle cells in human atherosclerotic carotid plaques. Thromb Haemost. 107:140–149. 2012. View Article : Google Scholar | |
Holden RM, Hétu MF, Li TY, Ward EC, Couture LE, Herr JE, Christilaw E, Adams MA and Johri AM: Circulating Gas6 is associated with reduced human carotid atherosclerotic plaque burden in high risk cardiac patients. Clin Biochem. 64:6–11. 2019. View Article : Google Scholar | |
Tjwa M, Moons L and Lutgens E: Pleiotropic role of growth arrest-specific gene 6 in atherosclerosis. Curr Opin Lipidol. 20:386–392. 2009. View Article : Google Scholar : PubMed/NCBI | |
Meir KS and Leitersdorf E: Atherosclerosis in the apolipoprotein-E-deficient mouse: A decade of progress. Arterioscler Thromb Vasc Biol. 24:1006–1014. 2004. View Article : Google Scholar : PubMed/NCBI | |
Park JK, Theuer S, Kirsch T, Lindschau C, Klinge U, Heuser A, Plehm R, Todiras M, Carmeliet P, Haller H, et al: Growth arrest specific protein 6 participates in DOCA-induced target-organ damage. Hypertension. 54:359–364. 2009. View Article : Google Scholar : PubMed/NCBI | |
Zhao YF, Xu DC, Zhu GF, Zhu M, Tang K, Li WM and Xu YW: Growth arrest-specific 6 exacerbates pressure overload-induced cardiac hypertrophy. Hypertension. 67:118–129. 2016. View Article : Google Scholar | |
van der Meer JH, van der Poll T and van 't Veer C: TAM receptors, Gas6, and protein S: Roles in inflammation and hemostasis. Blood. 123:2460–2469. 2014. View Article : Google Scholar : PubMed/NCBI | |
Zhao GJ, Zheng JY, Bian JL, Chen LW, Dong N, Yu Y, Hong GL, Chandoo A, Yao YM and Lu ZQ: Growth arrest-specific 6 enhances the suppressive function of CD4+CD25+ regulatory T cells mainly through axl receptor. Mediators Inflamm. 2017:68484302017. | |
Haase VH: Mechanisms of hypoxia responses in renal tissue. J Am Soc Nephrol. 24:537–541. 2013. View Article : Google Scholar : PubMed/NCBI | |
Giangola MD, Yang WL, Rajayer SR, Kuncewitch M, Molmenti E, Nicastro J, Coppa GF and Wang P: Growth arrest-specific protein 6 protects against renal ischemia-reperfusion injury. J Surg Res. 199:572–579. 2015. View Article : Google Scholar : PubMed/NCBI | |
Ishimoto Y, Ohashi K, Mizuno K and Nakano T: Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6. J Biochem. 127:411–417. 2000. View Article : Google Scholar : PubMed/NCBI | |
Lee IJ, Hilliard B, Swami A, Madara JC, Rao S, Patel T, Gaughan JP, Lee J, Gadegbeku CA, Choi ET and Cohen PL: Growth arrest-specific gene 6 (Gas6) levels are elevated in patients with chronic renal failure. Nephrol Dial Transplant. 27:4166–4172. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hallajzadeh J, Ghorbanihaghjo A, Argani H, Dastmalchi S and Rashtchizadeh N: Growth arrest-specific 6 protein and matrix Gla protein in hemodialysis patients. Iran J Kidney Dis. 9:249–255. 2015.PubMed/NCBI | |
Panichi V, Migliori M, De Pietro S, Taccola D, Bianchi AM, Giovannini L, Norpoth M, Metelli MR, Cristofani R, Bertelli AAE, et al: C-reactive protein and interleukin-6 levels are related to renal function in predialytic chronic renal failure. Nephron. 91:594–600. 2002. View Article : Google Scholar : PubMed/NCBI | |
Weiner DE, Tabatabai S, Tighiouart H, Elsayed E, Bansal N, Griffith J, Salem DN, Levey AS and Sarnak MJ: Cardiovascular outcomes and all-cause mortality: Exploring the interaction between CKD and cardiovascular disease. Am J Kidney Dis. 48:392–401. 2006. View Article : Google Scholar : PubMed/NCBI | |
Silaghi CN, Ilyés T, Filip VP, Farca M, van Ballegooijen AJ and Crăciun AM: Vitamin K dependent proteins in kidney disease. Int J Mol Sci. 20:15712019. View Article : Google Scholar : | |
Wu CS, Hu CY, Tsai HF, Chyuan IT, Chan CJ, Chang SK and Hsu PN: Elevated serum level of growth arrest-specific protein 6 (Gas6) in systemic lupus erythematosus patients is associated with nephritis and cutaneous vasculitis. Rheumatol Int. 34:625–629. 2014. View Article : Google Scholar | |
Nagai K, Miyoshi M, Kake T, Fukushima N, Matsuura M, Shibata E, Yamada S, Yoshikawa K, Kanayama HO, Fukawa T, et al: Dual involvement of growth arrest-specific gene 6 in the early phase of human IgA nephropathy. PLoS One. 8:e667592013. View Article : Google Scholar : PubMed/NCBI | |
Nagai K, Arai H, Yanagita M, Matsubara T, Kanamori H, Nakano T, Iehara N, Fukatsu A, Kita T and Doi T: Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy. J Biol Chem. 278:18229–18234. 2003. View Article : Google Scholar : PubMed/NCBI | |
Nagai K, Matsubara T, Mima A, Sumi E, Kanamori H, Iehara N, Fukatsu A, Yanagita M, Nakano T, Ishimoto Y, et al: Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy. Kidney Int. 68:552–561. 2005. View Article : Google Scholar : PubMed/NCBI | |
Hung YJ, Lee CH, Chu NF and Shieh YS: Plasma protein growth arrest-specific 6 levels are associated with altered glucose tolerance, inflammation, and endothelial dysfunction. Diabetes Care. 33:1840–1844. 2010. View Article : Google Scholar : PubMed/NCBI | |
Li W, Wang J, Ge L, Shan J, Zhang C and Liu J: Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy. Clin Exp Hypertens. 39:382–387. 2017. View Article : Google Scholar : PubMed/NCBI | |
Tian W, Wang L, Yuan L, Duan W, Zhao W, Wang S and Zhang Q: A prognostic risk model for patients with triple negative breast cancer based on stromal natural killer cells, tumor-associated macrophages and growth-arrest specific protein 6. Cancer Sci. 107:882–889. 2016. View Article : Google Scholar : PubMed/NCBI | |
Ammoun S, Provenzano L, Zhou L, Barczyk M, Evans K, Hilton DA, Hafizi S and Hanemann CO: Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival. Oncogene. 33:336–346. 2014. View Article : Google Scholar | |
Buehler M, Tse B, Leboucq A, Jacob F, Caduff R, Fink D, Goldstein DR and Heinzelmann-Schwarz V: Meta-analysis of microarray data identifies GAS6 expression as an independent predictor of poor survival in ovarian cancer. Biomed Res Int. 2013:2382842013. View Article : Google Scholar : PubMed/NCBI | |
Loges S, Schmidt T, Tjwa M, van Geyte K, Lievens D, Lutgens E, Vanhoutte D, Borgel D, Plaisance S, Hoylaerts M, et al: Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6. Blood. 115:2264–2273. 2010. View Article : Google Scholar | |
Waizenegger JS, Ben-Batalla I, Weinhold N, Meissner T, Wroblewski M, Janning M, Riecken K, Binder M, Atanackovic D, Taipaleenmaeki H, et al: Role of growth arrest-specific gene 6-Mer axis in multiple myeloma. Leukemia. 29:696–704. 2015. View Article : Google Scholar | |
Husain H, Scur M, Murtuza A, Bui N, Woodward B and Kurzrock R: Strategies to overcome bypass mechanisms mediating clinical resistance to EGFR tyrosine kinase inhibition in lung cancer. Mol Cancer Ther. 16:265–272. 2017. View Article : Google Scholar : PubMed/NCBI | |
Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, et al: The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 507:508–512. 2014. View Article : Google Scholar : PubMed/NCBI | |
Viegas CS, Simes DC, Laizé V, Williamson MK, Price PA and Cancela ML: Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. J Biol Chem. 283:36655–36664. 2008. View Article : Google Scholar : PubMed/NCBI | |
Viegas CS, Rafael MS, Enriquez JL, Teixeira A, Vitorino R, Luís IM, Costa RM, Santos S, Cavaco S, Neves J, et al: Gla-rich protein acts as a calcification inhibitor in the human cardiovascular system. Arterioscler Thromb Vasc Biol. 35:399–408. 2015. View Article : Google Scholar | |
Surmann-Schmitt C, Dietz U, Kireva T, Adam N, Park J, Tagariello A, Onnerfjord P, Heinegård D, Schlötzer-Schrehardt U, Deutzmann R, et al: Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. J Biol Chem. 283:7082–7093. 2008. View Article : Google Scholar | |
Neacsu CD, Grosch M, Tejada M, Winterpacht A, Paulsson M, Wagener R and Tagariello A: Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate γ-carboxylation. Matrix Biol. 30:369–378. 2011. View Article : Google Scholar : PubMed/NCBI | |
Cancela ML, Conceição N and Laizé V: Gla-rich protein, a new player in tissue calcification? Adv Nutr. 3:174–181. 2012. View Article : Google Scholar : PubMed/NCBI | |
Mackie EJ, Tatarczuch L and Mirams M: The skeleton: A multi-functional complex organ: The growth plate chondrocyte and endochondral ossification. J Endocrinol. 211:109–121. 2011. View Article : Google Scholar : PubMed/NCBI | |
Granadeiro L, Dirks RP, Ortiz-Delgado JB, Gavaia PJ, Sarasquete C, Laizé V, Cancela ML and Fernández I: Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner-from molecular mechanisms to environmental concerns. Ecotoxicol Environ Saf. 181:559–571. 2019. View Article : Google Scholar : PubMed/NCBI | |
R Sousa A, Barreira R and Santos E: Low-dose warfarin maternal anticoagulation and fetal warfarin syndrome. BMJ Case Rep. 2018:bcr20172231592018. View Article : Google Scholar | |
Maruotti N, Corrado A and Cantatore FP: Osteoblast role in osteoarthritis pathogenesis. J Cell Physiol. 232:2957–2963. 2017. View Article : Google Scholar : PubMed/NCBI | |
Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JYL and Henrotin YE: Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes. Osteoarthritis Cartilage. 13:988–997. 2005. View Article : Google Scholar : PubMed/NCBI | |
Sokolove J and Lepus CM: Role of inflammation in the pathogenesis of osteoarthritis: Latest findings and interpretations. Ther Adv Musculoskelet Dis. 5:77–94. 2013. View Article : Google Scholar : PubMed/NCBI | |
Okuyan HM, Terzi MY, Ozcan O and Kalaci A: Association of UCMA levels in serum and synovial fluid with severity of knee osteoarthritis. Int J Rheum Dis. 22:1884–1890. 2019. View Article : Google Scholar : PubMed/NCBI | |
Misra D, Booth SL, Tolstykh I, Felson DT, Nevitt MC, Lewis CE, Torner J and Neogi T: Vitamin K deficiency is associated with incident knee osteoarthritis. Am J Med. 126:243–248. 2013. View Article : Google Scholar : PubMed/NCBI | |
Hunt JL, Fairman R, Mitchell ME, Carpenter JP, Golden M, Khalapyan T, Wolfe M, Neschis D, Milner R, Scoll B, et al: Bone formation in carotid plaques: A clinicopathological study. Stroke. 33:1214–1219. 2002. View Article : Google Scholar : PubMed/NCBI | |
Cozzolino M, Fusaro M, Ciceri P, Gasperoni L and Cianciolo G: The role of vitamin K in vascular calcification. Adv Chronic Kidney Dis. 26:437–444. 2019. View Article : Google Scholar : PubMed/NCBI | |
Hruska KA: Vascular smooth muscle cells in the pathogenesis of vascular calcification. Circ Res. 104:710–711. 2009. View Article : Google Scholar : PubMed/NCBI | |
Dhore CR, Cleutjens JP, Lutgens E, Cleutjens KB, Geusens PP, Kitslaar PJ, Tordoir JH, Spronk HM, Vermeer C and Daemen MJ: Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 21:1998–2003. 2001. View Article : Google Scholar : PubMed/NCBI | |
Kapustin AN and Shanahan CM: Calcium regulation of vascular smooth muscle cell-derived matrix vesicles. Trends Cardiovasc Med. 22:133–137. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kapustin AN, Davies JD, Reynolds JL, McNair R, Jones GT, Sidibe A, Schurgers LJ, Skepper JN, Proudfoot D, Mayr M and Shanahan CM: Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization. Circ Res. 109:e1–e12. 2011. View Article : Google Scholar : PubMed/NCBI | |
Toroian D, Lim JE and Price PA: The size exclusion characteristics of type I collagen: Implications for the role of noncollagenous bone constituents in mineralization. J Biol Chem. 282:22437–22447. 2007. View Article : Google Scholar : PubMed/NCBI | |
Price PA, Toroian D and Lim JE: Mineralization by inhibitor exclusion: The calcification of collagen with fetuin. J Biol Chem. 284:17092–17101. 2009. View Article : Google Scholar : PubMed/NCBI | |
New SEP and Aikawa E: Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification. Circ Res. 108:1381–1391. 2011. View Article : Google Scholar : PubMed/NCBI | |
Ikeda K, Souma Y, Akakabe Y, Kitamura Y, Matsuo K, Shimoda Y, Ueyama T, Matoba S, Yamada H, Okigaki M and Matsubara H: Macrophages play a unique role in the plaque calcification by enhancing the osteogenic signals exerted by vascular smooth muscle cells. Biochem Biophys Res Commun. 425:39–44. 2012. View Article : Google Scholar : PubMed/NCBI | |
New SEP, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K and Aikawa E: Macrophage-derived matrix vesicles: An alternative novel mechanism for microcalcification in atherosclerotic plaques. Circ Res. 113:72–77. 2013. View Article : Google Scholar : PubMed/NCBI | |
Evrard S, Delanaye P, Kamel S, Cristol JP and Cavalier E: SFBC/SN joined working group on vascular calcifications: Vascular calcification: From pathophysiology to biomarkers. Clin Chim Acta. 438:401–414. 2015. View Article : Google Scholar | |
Tesfamariam B: Involvement of vitamin K-dependent proteins in vascular calcification. J Cardiovasc Pharmacol Ther. 24:323–333. 2019. View Article : Google Scholar : PubMed/NCBI | |
Viegas CSB, Santos L, Macedo AL, Matos AA, Silva AP, Neves PL, Staes A, Gevaert K, Morais R, Vermeer C, et al: Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: A role for GRP (Gla-Rich Protein). Arterioscler Thromb Vasc Biol. 38:575–587. 2018. View Article : Google Scholar : PubMed/NCBI | |
Pasch A, Farese S, Gräber S, Wald J, Richtering W, Floege J and Jahnen-Dechent W: Nanoparticle-based test measures overall propensity for calcification in serum. J Am Soc Nephrol. 23:1744–1752. 2012. View Article : Google Scholar : PubMed/NCBI | |
Viegas CSB, Costa RM, Santos L, Videira PA, Silva Z, Araújo N, Macedo AL, Matos AP, Vermeer C and Simes DC: Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases. PLoS One. 12:e01778292017. View Article : Google Scholar : PubMed/NCBI | |
Willems BA, Furmanik M, Caron MMJ, Chatrou MLL, Kusters DHM, Welting TJM, Stock M, Rafael MS, Viegas CSB, Simes DC, et al: Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling. Sci Rep. 8:49612018. View Article : Google Scholar : PubMed/NCBI | |
Karamouzis MV, Likaki-Karatza E, Ravazoula P, Badra FA, Koukouras D, Tzorakoleftherakis E, Papavassiliou AG and Kalofonos HP: Non-palpable breast carcinomas: Correlation of mammographically detected malignant-appearing microcalcifications and molecular prognostic factors. Int J Cancer. 102:86–90. 2002. View Article : Google Scholar : PubMed/NCBI | |
Kim JH, Ko ES, Kim DY, Han H, Sohn JH and Choe DH: Noncalcified ductal carcinoma in situ: Imaging and histologic findings in 36 tumors. J Ultrasound Med. 28:903–910. 2009. View Article : Google Scholar : PubMed/NCBI | |
Avdan Aslan A, Gültekin S, Esendağli Yilmaz G and Kurukahvecioğlu O: Is there any association between mammographic features of microcalcifications and breast cancer subtypes in ductal carcinoma in situ? Acad Radiol. Jun 30–2020.Online ahead of print. View Article : Google Scholar : PubMed/NCBI | |
Viegas CS, Herfs M, Rafael MS, Enriquez JL, Teixeira A, Luís IM, van 't Hoofd CM, João A, Maria VL, Cavaco S, et al: Gla-rich protein is a potential new vitamin K target in cancer: Evidences for a direct GRP-mineral interaction. Biomed Res Int. 2014:3402162014. View Article : Google Scholar : PubMed/NCBI | |
Huisse MG, Leclercq M, Belghiti J, Flejou JF, Suttie JW, Bezeaud A, Stafford DW and Guillin MC: Mechanism of the abnormal vitamin K-dependent gamma-carboxylation process in human hepatocellular carcinomas. Cancer. 74:1533–1541. 1994. View Article : Google Scholar : PubMed/NCBI | |
Pasierski T: Vitamin K antagonists in anticoagulant therapy of patients with cancer. Pol Arch Med Wewn. 122:60–64. 2012.PubMed/NCBI | |
Vermeer C: Vitamin K: The effect on health beyond coagulation-an overview. Food Nutr Res. 56:2012. View Article : Google Scholar | |
Cox RF, Hernandez-Santana A, Ramdass S, McMahon G, Harmey JH and Morgan MP: Microcalcifications in breast cancer: Novel insights into the molecular mechanism and functional consequence of mammary mineralisation. Br J Cancer. 106:525–537. 2012. View Article : Google Scholar : PubMed/NCBI | |
Takeshita S, Kikuno R, Tezuka K and Amann E: Osteoblast-specific factor 2: Cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 294:271–278. 1993. View Article : Google Scholar : PubMed/NCBI | |
Coutu DL, Wu JH, Monette A, Rivard GE, Blostein MD and Galipeau J: Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. J Biol Chem. 283:17991–8001. 2008. View Article : Google Scholar : PubMed/NCBI | |
Zhong H, Li X, Zhang J and Wu X: Overexpression of periostin is positively associated with gastric cancer metastasis through promoting tumor metastasis and invasion. J Cell Biochem. 120:9927–9935. 2019. View Article : Google Scholar : PubMed/NCBI | |
Nakazawa T, Nakajima A, Seki N, Okawa A, Kato M, Moriya H, Amizuka N, Einhorn TA and Yamazaki M: Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis. J Orthop Res. 22:520–525. 2004. View Article : Google Scholar : PubMed/NCBI | |
Li W, Gao P, Zhi Y, Xu W, Wu Y, Yin J and Zhang J: Periostin: Its role in asthma and its potential as a diagnostic or therapeutic target. Respir Res. 16:572015. View Article : Google Scholar : PubMed/NCBI | |
Duchamp de Lageneste O and Colnot C: Periostin in bone regeneration. Adv Exp Med Biol. 1132:49–61. 2019. View Article : Google Scholar : PubMed/NCBI | |
Ai-Aql ZS, Alagl AS, Graves DT, Gerstenfeld LC and Einhorn TA: Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res. 87:107–118. 2008. View Article : Google Scholar : PubMed/NCBI | |
Einhorn TA and Gerstenfeld LC: Fracture healing: Mechanisms and interventions. Nat Rev Rheumatol. 11:45–54. 2015. View Article : Google Scholar : | |
Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ and Guldberg RE: Periosteal progenitor cell fate in segmental cortical bone graft transplantations: Implications for functional tissue engineering. J Bone Miner Res. 20:2124–2137. 2005. View Article : Google Scholar : PubMed/NCBI | |
Neagu TP, Ţigliş M, Cocoloş I and Jecan CR: The relationship between periosteum and fracture healing. Rom J Morphol Embryol. 57:1215–1220. 2016. | |
Kudo A: Periostin in bone biology. Adv Exp Med Biol. 1132:43–47. 2019. View Article : Google Scholar : PubMed/NCBI | |
Allen MR, Hock JM and Burr DB: Periosteum: Biology, regulation, and response to osteoporosis therapies. Bone. 35:1003–1012. 2004. View Article : Google Scholar : PubMed/NCBI | |
Kashima TG, Nishiyama T, Shimazu K, Shimazaki M, Kii I, Grigoriadis AE, Fukayama M and Kudo A: Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions. Hum Pathol. 40:226–237. 2009. View Article : Google Scholar | |
Varughese R, Semprini R, Munro C, Fingleton J, Holweg C, Weatherall M, Beasley R and Braithwaite I: Serum periostin levels following small bone fractures, long bone fractures and joint replacements: An observational study. Allergy Asthma Clin Immunol. 14:302018. View Article : Google Scholar : PubMed/NCBI | |
Roberts SJ, van Gastel N, Carmeliet G, Carmeliet G and Luyten FP: Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath. Bone. 70:10–18. 2015. View Article : Google Scholar | |
Matsuzawa M, Arai C, Nomura Y, Murata T, Yamakoshi Y, Oida S, Hanada N and Nakamura Y: Periostin of human periodontal ligament fibroblasts promotes migration of human mesenchymal stem cell through the αvβ3 integrin/FAK/PI3K/Akt pathway. J Periodont Res. 50:855–863. 2015. View Article : Google Scholar | |
Hwang EY, Jeong MS, Park EK, Kim JH and Jang SB: Structural characterization and interaction of periostin and bone morphogenetic protein for regulation of collagen cross-linking. Biochem Biophys Res Commun. 449:425–431. 2014. View Article : Google Scholar : PubMed/NCBI | |
Rezaieyazdi Z, Falsoleiman H, Khajehdaluee M, Saghafi M and Mokhtari-Amirmajdi E: Reduced bone density in patients on long-term warfarin. Int J Rheum Dis. 12:130–135. 2009. View Article : Google Scholar | |
Tufano A, Coppola A, Contaldi P, Franchini M and Minno GD: Oral anticoagulant drugs and the risk of osteoporosis: New anticoagulants better than old? Semin Thromb Hemost. 41:382–388. 2015. View Article : Google Scholar : PubMed/NCBI | |
Jeong HM, Cho DH, Jin YH, Chung JO, Chung MY, Chung DJ and Lee KY: Inhibition of osteoblastic differentiation by warfarin and 18-α-glycyrrhetinic acid. Arch Pharm Res. 34:1381–1387. 2011. View Article : Google Scholar : PubMed/NCBI | |
Verma D, Kumar R, Pereira RS, Karantanou C, Zanetti C, Minciacchi VR, Fulzele K, Kunz K, Hoelper S, Zia-Chahabi S, et al: Vitamin K antagonism impairs the bone marrow microenvironment and hematopoiesis. Blood. 134:227–238. 2019. View Article : Google Scholar : PubMed/NCBI | |
Sugimoto I, Hirakawa K, Ishino T, Takeno S and Yajin K: Vitamin D3, vitamin K2, and warfarin regulate bone metabolism in human paranasal sinus bones. Rhinology. 45:208–213. 2007.PubMed/NCBI | |
Rousseau JC, Sornay-Rendu E, Bertholon C, Chapurlat R and Garnero P: Serum periostin is associated with fracture risk in postmenopausal women: A 7-year prospective analysis of the OFELY study. J Clin Endocrinol Metab. 99:2533–2539. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kim BJ, Rhee Y, Kim CH, Baek KH, Min YK, Kim DY, Ahn SH, Kim H, Lee SH, Lee SY, et al: Plasma periostin associates significantly with non-vertebral but not vertebral fractures in post-menopausal women: Clinical evidence for the different effects of periostin depending on the skeletal site. Bone. 81:435–441. 2015. View Article : Google Scholar : PubMed/NCBI | |
Rousseau JC, Sornay-Rendu E, Bertholon C, Garnero P and Chapurlat R: Serum periostin is associated with prevalent knee osteoarthritis and disease incidence/progression in women: The OFELY study. Osteoarthr Cartil. 23:1736–1742. 2015. View Article : Google Scholar | |
Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram DA, Menick D, Field L, et al: Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res. 102:752–760. 2008. View Article : Google Scholar : PubMed/NCBI | |
Nagaraju CK, Robinson EL, Abdesselem M, Trenson S, Dries E, Gilbert G, Janssens S, Van Cleemput J, Rega F, Meyns B, et al: Myofibroblast phenotype and reversibility of fibrosis in patients with end-stage heart failure. J Am Coll Cardiol. 73:2267–2282. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zheng X, Wang S, Zou X, Jing Y, Yang R, Li S and Wang F: Ginsenoside Rb1 improves cardiac function and remodeling in heart failure. Exp Anim. 66:217–228. 2017. View Article : Google Scholar : PubMed/NCBI | |
Chen Z, Xie J, Hao H, Lin H, Wang L, Zhang Y, Chen L, Cao S, Huang X, Liao W, et al: Ablation of periostin inhibits post-infarction myocardial regeneration in neonatal mice mediated by the phosphatidylinositol 3 kinase/glycogen synthase kinase 3β/cyclin D1 signalling pathway. Cardiovasc Res. 113:620–632. 2017. View Article : Google Scholar : PubMed/NCBI | |
Hixson JE, Shimmin LC, Montasser ME, Kim DK, Zhong Y, Ibarguen H, Follis J, Malcom G, Strong J, Howard T, et al: Common variants in the periostin gene influence development of atherosclerosis in young persons. Arterioscler Thromb Vasc Biol. 31:1661–1667. 2011. View Article : Google Scholar : PubMed/NCBI | |
Hakuno D, Kimura N, Yoshioka M, Mukai M, Kimura T, Okada Y, Yozu R, Shukunami C, Hiraki Y, Kudo A, et al: Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents. J Clin Invest. 120:2292–2306. 2010. View Article : Google Scholar : PubMed/NCBI | |
Lindner V, Wang Q, Conley BA, Friesel RE and Vary CP: Vascular injury induces expression of periostin: Implications for vascular cell differentiation and migration. Arterioscler Thromb Vasc Biol. 25:77–83. 2005. View Article : Google Scholar | |
Schwanekamp JA, Lorts A, Vagnozzi RJ, Vanhoutte D and Molkentin JD: Deletion of periostin protects against atherosclerosis in mice by altering inflammation and extracellular matrix remodeling. Arterioscler Thromb Vasc Biol. 36:60–68. 2016. View Article : Google Scholar | |
Ahlfeld SK, Gao Y, Wang J, Horgusluoglu E, Bolanis E, Clapp DW and Conway SJ: Periostin downregulation is an early marker of inhibited neonatal murine lung alveolar septation. Birth Defects Res A Clin Mol Teratol. 97:373–385. 2013. View Article : Google Scholar : PubMed/NCBI | |
Bozyk PD, Bentley JK, Popova AP, Anyanwu AC, Linn MD, Goldsmith AM, Pryhuber GS, Moore BB and Hershenson MB: Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication. PLoS One. 7:e313362012. View Article : Google Scholar : PubMed/NCBI | |
Naik PK, Bozyk PD, Bentley JK, Popova AP, Birch CM, Wilke CA, Fry CD, White ES, Sisson TH, Tayob N, et al: Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 303:L1046–L1056. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kanemitsu Y, Suzuki M, Fukumitsu K, Asano T, Takeda N, Nakamura Y, Ozawa Y, Masaki A, Ono J, Kurokawa R, et al: A novel pathophysiologic link between upper and lower airways in patients with chronic rhinosinusitis: Association of sputum periostin levels with upper airway inflammation and olfactory function. World Allergy Organ J. 13:1000942020. View Article : Google Scholar : PubMed/NCBI | |
Katoh S, Matsumoto N, Tanaka H, Yasokawa N, Kittaka M, Kurose K, Abe M, Yoshioka D, Shirai R, Nakazato M and Kobashi Y: Elevated levels of periostin and TGF-β1 in the bronchoalveolar lavage fluid of patients with idiopathic eosinophilic pneumonia. Asian Pac J Allergy Immunol. 38:208–213. 2020. | |
Tanaka J, Hebisawa A, Oguma T, Tomomatsu K, Suzuki J, Shimizu H, Kawabata Y, Ishiguro T, Takayanagi N, Ueda S, et al: Evaluating serum periostin levels in allergic bronchopulmonary aspergillosis. Allergy. 75:974–977. 2020. View Article : Google Scholar | |
Wilson MS and Wynn TA: Pulmonary fibrosis: Pathogenesis, etiology and regulation. Mucosal Immunol. 2:103–121. 2009. View Article : Google Scholar : PubMed/NCBI | |
Behr J, Kreuter M, Hoeper MM, Wirtz H, Klotsche J, Koschel D, Andreas S, Claussen M, Grohé C, Wilkens H, et al: Management of patients with idiopathic pulmonary fibrosis in clinical practice: The INSIGHTS-IPF registry. Eur Respir J. 46:186–196. 2015. View Article : Google Scholar : PubMed/NCBI | |
Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Kawayama T, Fujimoto K, Ohshima K, Shiraishi H, Uchida M, Ono J, et al: Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. Eur Respir J. 37:1119–1127. 2011. View Article : Google Scholar | |
Nance T, Smith KS, Anaya V, Richardson R, Ho L, Pala M, Mostafavi S, Battle A, Feghali-Bostwick C, Rosen G and Montgomery SB: Transcriptome analysis reveals differential splicing events in IPF lung tissue. PLoS One. 9:e975502014. View Article : Google Scholar : PubMed/NCBI | |
Ashley SL, Wilke CA, Kim KK and Moore BB: Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis. Mucosal Immunol. 10:341–351. 2017. View Article : Google Scholar : | |
Yoshihara T, Nanri Y, Nunomura S, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, Mawatari M and Izuhara K: Periostin plays a critical role in the cell cycle in lung fibroblasts. Respir Res. 21:382020. View Article : Google Scholar : PubMed/NCBI | |
Nanri Y, Nunomura S, Terasaki Y, Yoshihara T, Hirano Y, Yokosaki Y, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, et al: Cross-talk between transforming growth factor-beta and periostin can be targeted for pulmonary fibrosis. Am J Respir Cell Mol Biol. 62:204–216. 2020. View Article : Google Scholar | |
De Brouwer B, Piscaer I, Von Der Thusen JH, Grutters JC, Schutgens RE, Wouters EF and Janssen R: Should vitamin K be supplemented instead of antagonised in patients with idiopathic pulmonary fibrosis? Expert Rev Respir Med. 12:169–175. 2018. View Article : Google Scholar : PubMed/NCBI | |
Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, et al: Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA. 104:15858–15863. 2007. View Article : Google Scholar : PubMed/NCBI | |
Izuhara K, Nunomura S, Nanri Y, Ogawa M, Ono J, Mitamura Y and Yoshihara T: Periostin in inflammation and allergy. Cell Mol Life Sci. 74:4293–4303. 2017. View Article : Google Scholar : PubMed/NCBI | |
Tartibi HM and Bahna SL: Clinical and biological markers of asthma control. Expert Rev Clin Immunol. 10:1453–1461. 2014. View Article : Google Scholar : PubMed/NCBI | |
Johansson MW, Annis DS and Mosher DF: α(M)β(2) integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin. Am J Respir Cell Mol Biol. 48:503–510. 2013. View Article : Google Scholar : PubMed/NCBI | |
Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, Muller SJ and Fahy JV: Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci USA. 107:14170–14175. 2010. View Article : Google Scholar : PubMed/NCBI | |
Kimur I, Tanizaki Y, Sato S, Saito K and Takahashi K: Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma. Acta medica Okayama. 29:127–135. 1975.PubMed/NCBI | |
Litonjua AA: Fat-soluble vitamins and atopic disease: What is the evidence? Proc Nutr Soc. 71:67–74. 2012. View Article : Google Scholar : | |
El Basha NR, Osman HM, Abdelaal AA, Saed SM and Shaaban HH: Increased expression of serum periostin and YKL40 in children with severe asthma and asthma exacerbation. J Investig Med. 66:1102–1108. 2018. View Article : Google Scholar : PubMed/NCBI | |
Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, Sakamaki F, Oyamada Y, Inoue T, Oguma T, et al: Phenotype of asthma related with high serum periostin levels. Allergol Int. 64:175–180. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kim MA, Izuhara K, Ohta S, Ono J, Yoon MK, Ban GY, Yoo HS, Shin YS, Ye YM, Nahm DH and Park HS: Association of serum periostin with aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 113:314–320. 2014. View Article : Google Scholar : PubMed/NCBI | |
Asano T, Kanemitsu Y, Takemura M, Yokota M, Fukumitsu K, Takeda N, Ichikawa H, Uemura T, Takakuwa O, Ohkubo H, et al: Serum periostin as a biomarker for comorbid chronic rhinosinusitis in patients with asthma. Ann Am Thorac Soc. 14:667–675. 2017. View Article : Google Scholar : PubMed/NCBI | |
Cianchetti S, Cardini C, Puxeddu I, Latorre M, Bartoli ML, Bradicich M, Dente F, Bacci E, Celi A and Paggiaro P: Distinct profile of inflammatory and remodelling biomarkers in sputum of severe asthmatic patients with or without persistent airway obstruction. World Allergy Organ J. 12:1000782019. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Chen JP, Duan L and Li S: Effect of vitamin K2 on type 2 diabetes mellitus: A review. Diabetes Res Clin Pract. 136:39–51. 2018. View Article : Google Scholar | |
Mukai K, Morimoto H, Kikuchi S and Nagaoka S: Kinetic study of free-radical-scavenging action of biological hydroquinones (reduced forms of ubiquinone, vitamin K and tocopherol quinone) in solution. Biochim Biophys Acta. 1157:313–317. 1993. View Article : Google Scholar : PubMed/NCBI | |
Westhofen P, Watzka M, Marinova M, Hass M, Kirfel G, Müller J, Bevans CG, Müller CR and Oldenburg J: Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular anti-oxidant function. J Biol Chem. 286:15085–15094. 2011. View Article : Google Scholar : PubMed/NCBI | |
Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Van Meensel S, Schaap O, De Strooper B, Meganathan R, et al: Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science. 336:1306–1310. 2012. View Article : Google Scholar : PubMed/NCBI | |
Fujii S, Shimizu A, Takeda N, Oguchi K, Katsurai T, Shirakawa H, Komai M and Kagechika H: Systematic synthesis and anti-inflammatory activity of ω-carboxylated menaquinone derivatives-investigations on identified and putative vitamin K2 metabolites. Bioorg Med Chem. 23:2344–2352. 2015. View Article : Google Scholar : PubMed/NCBI | |
Myneni VD and Mezey E: Immunomodulatory effect of vitamin K2: Implications for bone health. Oral Dis. 24:67–71. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ishizuka M, Kubota K, Shimoda M, Kita J, Kato M, Park KH and Shiraki T: Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: A prospective randomized controlled trial. Anticancer Res. 32:5415–5420. 2012.PubMed/NCBI | |
Zhong JH, Mo XS, Xiang BD, Yuan WP, Jiang JF, Xie GS and Li LQ: Postoperative use of the chemopreventive vitamin K2 analog in patients with hepatocellular carcinoma. PLoS One. 8:e580822013. View Article : Google Scholar : PubMed/NCBI | |
Enomoto M, Tsuchida A, Miyazawa K, Yokoyama T, Kawakita H, Tokita H, Naito M, Itoh M, Ohyashiki K and Aoki T: Vitamin K2-induced cell growth inhibition via autophagy formation in cholangiocellular carcinoma cell lines. Int J Mol Med. 20:801–808. 2007.PubMed/NCBI | |
Sibayama-Imazu T, Fujisawa Y, Masuda Y, Aiuchi T, Nakajo S, Itabe H and Nakaya K: Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei. J Cancer Res Clin Oncol. 134:803–812. 2008. View Article : Google Scholar : PubMed/NCBI | |
Showalter SL, Wang Z, Costantino CL, Witkiewicz AK, Yeo CJ, Brody JR and Carr BI: Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway. J Gastroenterol Hepatol. 25:738–744. 2010. View Article : Google Scholar | |
Xv F, Chen J, Duan L and Li S: Research progress on the anticancer effects of vitamin K2. Oncol Lett. 15:8926–8934. 2018.PubMed/NCBI |