Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review)
- Authors:
- Francisco Javier Turrubiates‑Hernández
- Gabriela Athziri Sánchez‑Zuno
- Guillermo González‑Estevez
- Jorge Hernández‑Bello
- Gabriela Macedo‑Ojeda
- José Francisco Muñoz‑Valle
-
Affiliations: Institute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), Guadalajara, Jalisco 44340, México - Published online on: February 1, 2021 https://doi.org/10.3892/ijmm.2021.4865
- Article Number: 32
-
Copyright: © Turrubiates‑Hernández et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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 |
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|
da Costa VG, Moreli ML and Saivish MV: The emergence of SARS, MERS and novel SARS-2 coronaviruses in the 21st century. Arch Virol. 165:1517–1526. 2020. View Article : Google Scholar | |
|
Lee C: Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus. Virol J. 12:1932015. View Article : Google Scholar : PubMed/NCBI | |
|
Bande F, Arshad SS, Bejo MH, Moeini H and Omar AR: Progress and challenges toward the development of vaccines against avian infectious bronchitis. J Immunol Res. 2015:4248602015. View Article : Google Scholar : PubMed/NCBI | |
|
Fouchier RA, Kuiken T, Schutten M, van Amerongen G, van Doornum GJ, van den Hoogen BG, Peiris M, Lim W, Stohr K and Osterhaus AD: Aetiology: Koch's postulates fulfilled for SARS virus. Nature. 423:2402003. View Article : Google Scholar : PubMed/NCBI | |
|
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus ADME and Fouchier RAM: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 367:1814–1820. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al: A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 382:727–733. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Coronaviridae Study Group of the International Committee on Taxonomy of Viruses: The species Severe acute respiratory syndrome-related coronavirus: Classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 5:536–544. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
World Health Organization: Timeline of WHO's response to COVID-19. 2020. | |
|
Petrosillo N, Viceconte G, Ergonul O, Ippolito G and Petersen E: COVID-19, SARS and MERS: Are they closely related? Clin Microbiol Infect. 26:729–734. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, et al: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 395:507–513. 2020. View Article : Google Scholar : | |
|
Liu K, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, Xiao W, Wang YN, Zhong MH, Li CH, et al: Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl). 133:1025–1031. 2020. View Article : Google Scholar | |
|
Tang S, Mao Y, Jones RM, Tan Q, Ji JS, Li N, Shen J, LV Y, Pan L, Ding P, et al: Aerosol transmission of SARS-CoV-2? Evidence, prevention and control. Environ Int. 144:1060392020. View Article : Google Scholar : PubMed/NCBI | |
|
Sanche S, Lin YT, Xu C, Romero-Severson E, Hengartner N and KE R: High contagiousness and rapid spread of severe acute respiratory syndrome coronavirus 2. Emerg Infect Dis. 26:1470–1477. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Bauch CT, Lloyd-Smith JO, Coffee MP and Galvani AP: Dynamically modeling SARS and other newly emerging respiratory illnesses: Past, present, and future. Epidemiology. 16:791–801. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT and Veesler D: Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 181:281–292.e6. 2020. View Article : Google Scholar : | |
|
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, et al: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 181:271–280.e8. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zou X, Chen K, Zou J, Han P, Hao J and Han Z: Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 14:185–192. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Johns Hopkins University Coronavirus Resource Center: COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). 2020. | |
|
Zheng Z, Peng F, Xu B, Zhao J, Liu H, Peng J, Li Q, Jiang C, Zhou Y, Liu S, et al: Risk factors of critical & mortal COVID-19 cases. A systematic literature review and meta-analysis. J Infect. 81:e16–e25. 2020. View Article : Google Scholar | |
|
Peters R, Ee N, Peters J, Beckett N, Booth A, Rockwood K and Anstey KJ: Common risk factors for major noncommunicable disease, a systematic overview of reviews and commentary. The implied potential for targeted risk reduction. Ther Adv Chronic Dis. Oct 15–2019.Epub ahead of print. View Article : Google Scholar | |
|
Cena H and Calder PC: Defining a healthy diet: Evidence for the role of contemporary dietary patterns in health and disease. Nutrients. 12:3342020. View Article : Google Scholar : | |
|
Wu D, Lewis ED, Pae M and Meydani SN: Nutritional modulation of immune function. Analysis of evidence, mechanisms, and clinical relevance. Front Immunol. 9:31602019. View Article : Google Scholar | |
|
Forsyth C, Kouvari M, D'Cunha NM, Georgousopoulou EN, Panagiotakos DB, Mellor DD, Kellett J and Naumovski N: The effects of the Mediterranean diet on rheumatoid arthritis prevention and treatment. A systematic review of human prospective studies. Rheumatol Int. 38:737–747. 2018. View Article : Google Scholar | |
|
Zheng R, Gonzalez A, Yue J, Wu X, Qiu M, Gui L, Zhu S and Huang L: Efficacy and safety of vitamin D supplementation in patients with systemic lupus erythematosus. A meta-analysis of randomized controlled trials. Am J Med Sci. 358:104–114. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lee KR, Midgette Y and Shah R: Fish oil derived omega 3 fatty acids suppress adipose NLRP3 inflammasome signaling in human obesity. J Endocr Soc. 3:504–515. 2018. View Article : Google Scholar | |
|
Hussain MI, Ahmed W, Nasir M, Mushtaq MH, Sheikh AA, Shaheen AY and Mahmood A: Immune boosting role of vitamin E against pulmonary tuberculosis. Pak J Pharm Sci. 32(Suppl 1): S269–S276. 2019. | |
|
Martinez-Estevez NS, Alvarez-Guevara AN and Rodriguez-Martinez CE: Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children. A 12-month randomised controlled trial. Allergol Immunopathol (Madr). 44:368–375. 2016. View Article : Google Scholar | |
|
Zhang H, Yeh C, Jin Z, Ding L, Liu BY, Zhang L and Dannelly HK: Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate. Synth Syst Biotechnol. 3:113–120. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
McCarthy MS and Martindale RG: Immunonutrition in critical illness. What is the role? Nutr Clin Pract. 33:348–358. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chow O and Barbul A: Immunonutrition. Role in wound healing and tissue regeneration. Adv Wound Care (New Rochelle). 3:46–53. 2014. View Article : Google Scholar | |
|
Pilz S, Zittermann A, Trummer C, Theiler-Schwetz V, Lerchbaum E, Keppel MH, Grübler MR, März W and Pandis M: Vitamin D testing and treatment. A narrative review of current evidence. Endocr Connect. 8:R27–R43. 2019. View Article : Google Scholar | |
|
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, et al: Vitamin D supplementation to prevent acute respiratory tract infections. Systematic review and meta-analysis of individual participant data. BMJ. 356:i65832017. View Article : Google Scholar | |
|
Nair R, Maseeh A and Vitamin D: The 'sunshine' vitamin. J Pharmacol Pharmacother. 3:118–126. 2012.PubMed/NCBI | |
|
Roth DE, Abrams SA, Aloia J, Bergeron G, Bourassa MW, Brown KH, Calvo MS, Cashman KD, Combs G, De-Regil LM, et al: Global prevalence and disease burden of vitamin D deficiency: A roadmap for action in low- and middle-income countries. Ann NY Acad Sci. 1430:44–79. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Brito A, Cori H, Olivares M, Fernanda Mujica M, Cediel G and Lopez de Romana D: Less than adequate vitamin D status and intake in Latin America and the Caribbean. A problem of unknown magnitude. Food Nutr Bull. 34:52–64. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Ren LL, Wang YM, Wu ZQ, Xiang ZC, Guo L, Xu T, Jiang YZ, Xiong Y, Li YJ, Li XW, et al: Identification of a novel coronavirus causing severe pneumonia in human: A descriptive study. Chin Med J (Engl). 133:1015–1024. 2020. View Article : Google Scholar | |
|
Li W, Moore M J, Vasilieva N, Sui J, Wong S K, Berne M A, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, et al: Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 426:450–454. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Jia HP, Look DC, Shi L, Hickey M, Pewe L, Netland J, Farzan M, Wohlford-Lenane C, Perlman S and McCray PB Jr: ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol. 79:14614–14621. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Rabi FA, Al Zoubi MS, Kasasbeh GA, Salameh DM and Al-Nasser AD: SARS-CoV-2 and coronavirus disease 2019: What we know so far. Pathogens. 9:2312020. View Article : Google Scholar : | |
|
Yuki K, Fujiogi M and Koutsogiannaki S: COVID-19 pathophysiology: A review. Clin Immunol. 215:1084272020. View Article : Google Scholar : PubMed/NCBI | |
|
Banu N, Panikar SS, Leal LR and Leal AR: Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to macrophage activation syndrome: Therapeutic implications. Life Sci. 256:1179052020. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Geng M, Peng Y, Meng L and Lu S: Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 10:102–108. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Nile SH, Nile A, Qiu J, Li L, Jia X and Kai G: COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons. Cytokine Growth Factor Rev. 53:66–70. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Burki T: COVID-19 in Latin America. Lancet Infect Dis. 20:547–548. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Bolano-Ortiz TR, Camargo-Caicedo Y, Puliafito SE, Ruggeri MF, Bolano-Diaz S, Pascual-Flores R, Saturno J, Ibarra-Espinosa S, Mayol-Bracero OL, Torres-Delgado E and Cereceda-Balic F: Spread of SARS-CoV-2 through Latin America and the Caribbean region: A look from its economic conditions, climate and air pollution indicators. Environ Res. 191:1099382020. View Article : Google Scholar : PubMed/NCBI | |
|
World Health Organization: Our World in Data: Coronavirus (COVID-19) Vaccinations. 2021. | |
|
Guzman-Holst A, DeAntonio R, Prado-Cohrs D and Juliao P: Barriers to vaccination in Latin America: A systematic literature review. Vaccine. 38:470–481. 2020. View Article : Google Scholar | |
|
Pathak DSK, Salunke DAA, Thivari DP, Pandey A, Nandy DK, Harish VK, Ratna D, Pandey DS, Chawla DJ, Mujawar DJ, Dhanwate DA and Menon DV: No benefit of hydroxychloroquine in COVID-19: Results of systematic review and meta-analysis of randomized controlled trials'. Diabetes Metab Syndr. 14:1673–1680. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, et al: A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19. N Engl J Med. 382:1787–1799. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Novartis: Novartis provides update on CAN-COVID trial in hospitalized patients with COVID-19 pneumonia and cytokine release syndrome (CRS). 2020. | |
|
Sanofi: Sanofi provides update on Kevzara® (sarilumab) Phase 3 trial in severe and critically ill COVID-19 patients outside the U.S. 2020. | |
|
AstraZeneca: Update on CALAVI phase II trials for calquence in patients hospitalised with respiratory symptoms of COVID-19. 2020. | |
|
Iserson KV: SARS-CoV-2 (COVID-19) vaccine development and production: An ethical way forward. Camb Q Healthc Ethics. 30:59–68. 2021. View Article : Google Scholar | |
|
Bollyky TJ, Gostin LO and Hamburg MA: The equitable distribution of COVID-19 therapeutics and vaccines. JAMA. 323:2462–2463. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Barreto SM, Miranda JJ, Figueroa JP, Schmidt MI, Munoz S, Kuri-Morales PP and Silva JB Jr: Epidemiology in Latin America and the Caribbean: Current situation and challenges. Int J Epidemiol. 41:557–571. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zumla A, Hui DS, Azhar EI, Memish ZA and Maeurer M: Reducing mortality from 2019-nCoV: Host-directed therapies should be an option. Lancet. 395:e35–e36. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Rhodes JM, Subramanian S, Laird E and Kenny RA: Editorial: Low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity. Aliment Pharmacol Ther. 51:1434–1437. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Lamberg-Allardt C: Vitamin D in foods and as supplements. Prog Biophys Mol Biol. 92:33–38. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Jeon SM and Shin EA: Exploring vitamin D metabolism and function in cancer. Exp Mol Med. 50:202018. View Article : Google Scholar : PubMed/NCBI | |
|
Bikle DD: Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 21:319–329. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Christakos S, Dhawan P, Verstuyf A, Verlinden L and Carmeliet G: Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev. 96:365–408. 2016. View Article : Google Scholar : | |
|
Holick MF: Vitamin D deficiency. N Engl J Med. 357:266–281. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Bivona G, Agnello L and Ciaccio M: The immunological implication of the new vitamin D metabolism. Cent J Immunol. 43:331–334. 2018. View Article : Google Scholar | |
|
Charoenngam N and Holick MF: Immunologic effects of vitamin d on human health and disease. Nutrients. 12:20972020. View Article : Google Scholar : | |
|
Ghebrehewet S, MacPherson P and Ho A: Influenza. BMJ. 355:i62582016. View Article : Google Scholar : PubMed/NCBI | |
|
Tamerius JD, Shaman J, Alonso WJ, Bloom-Feshbach K, Uejio CK, Comrie A and Viboud C: Environmental predictors of seasonal influenza epidemics across temperate and tropical climates. PLoS Pathog. 9:e10031942013. View Article : Google Scholar : PubMed/NCBI | |
|
Arbeitskreis Blut, Untergruppe 'Bewertung Blutassoziierter Krankheitserreger': Influenza virus. Transfus Med Hemother. 36:32–39. 2009. View Article : Google Scholar | |
|
Hope-simpson RE: The role of season in the epidemiology of influenza. J Hyg (Lond). 86:35–47. 1981. View Article : Google Scholar | |
|
Cannell JJ, Vieth R, Umhau JC, Holick M F, Grant WB, Madronich S, Garland CF and Giovannucci E: Epidemic influenza and vitamin D. Epidemiol Infect. 134:1129–1140. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Mendes MM, Hart KH, Botelho PB and Lanham-New SA: Vitamin D status in the tropics: Is sunlight exposure the main determinant? Nutr Bull. 43:428–434. 2018. View Article : Google Scholar | |
|
Huotari A and Herzig KH: Vitamin D and living in northern latitudes-an endemic risk area for vitamin D deficiency. Int J Circumpolar Health. 67:164–178. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kmiec P, Zmijewski M, Waszak P, Sworczak K and Lizakowska-Kmiec M: Vitamin D deficiency during winter months among an adult, predominantly urban, population in Northern Poland. Endokrynol Pol. 65:105–113. 2014.PubMed/NCBI | |
|
Kmiec P, Zmijewski M, Lizakowska-Kmiec M and Sworczak K: Widespread vitamin D deficiency among adults from northern Poland (54°N) after months of low and high natural UVB radiation. Endokrynol Pol. 66:30–38. 2015. | |
|
Kroll MH, Bi C, Garber CC, Kaufman HW, Liu D, Caston-Balderrama A, Zhang K, Clarke N, Xie M, Reitz RE, et al: Temporal relationship between vitamin D status and parathyroid hormone in the United States. PLoS One. 10:e01181082015. View Article : Google Scholar : PubMed/NCBI | |
|
Greene-Finestone LS, Berger C, de Groh M, Hanley DA, Hidiroglou N, Sarafin K, Poliquin S, Krieger J, Richards JB and Goltzman D; CaMos Research Group: 25-Hydroxyvitamin D in canadian adults: Biological, environmental, and behavioral correlates. Osteoporos Int. 22:1389–1399. 2011. View Article : Google Scholar | |
|
Lowen AC, Mubareka S, Steel J and Palese P: Influenza virus transmission is dependent on relative humidity and temperature. PLoS Pathog. 3:1470–1476. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Lowen Ac and Steel J: Roles of humidity and temperature in shaping influenza seasonality. J Virol. 88:7692–7695. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Pham H, Rahman A, Majidi A, Waterhouse M and Neale RE: Acute respiratory tract infection and 25-hydroxyvitamin D concentration: A systematic review and meta-analysis. Int J Environ Res Public Health. 16:30202019. View Article : Google Scholar : | |
|
Ilie PC, Stefanescu S and Smith L: The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging clin Exp Res. 32:1195–1198. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Hastie CE, Mackay DF, Ho F, Celis-Morales CA, Katikireddi SV, Niedzwiedz CL, Jani BD, Welsh P, Mair FS, Gray SR, et al: Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr. 14:561–565. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
D'Avolio A, Avataneo V, Manca A, Cusato J, De Nicolo A, Lucchini R, Keller F and Cantù M: 25-Hydroxyvitamin D concentrations are lower in patients with positive PcR for SARS-coV-2. Nutrients. 12:13592020. View Article : Google Scholar : | |
|
Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V and Solway J: Association of vitamin D deficiency and treatment with cOVID-19 incidence. MedRxiv. 2020.05.08.20095893. 2020. | |
|
Whittemore PB: COVID-19 fatalities, latitude, sunlight, and vitamin D. Am J Infect control. 48:1042–1044. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Panagiotou G, Tee SA, Ihsan Y, Athar W, Marchitelli G, Kelly D, Boot CS, Stock N, Macfarlane J, Martineau AR, et al: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with cOVID-19 are associated with greater disease severity. Clin Endocrinol (Oxf). 93:508–511. 2020. View Article : Google Scholar | |
|
Merzon E, Tworowski D, Gorohovski A, Vinker S, Golan Cohen A, Green I and Frenkel Morgenstern M: Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: An Israeli population-based study. FEBS J. 287:3693–3702. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Batur LK and Hekim N: The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate. J Med Virol. Aug 8–2020.Epub ahead of print. | |
|
Carpagnano GE, Di Lecce V, Quaranta VN, Zito A, Buonamico E, Capozza E, Palumbo A, Di Gioia G, Valerio VN and Resta O: Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest. Aug 9–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
|
Abrishami A, Dalili N, Mohammadi Torbati P, Asgari R, Arab-Ahmadi M, Behnam B and Sanei-Taheri M: Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: A retrospective study. Eur J Nutr. Oct 30–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
|
De Smet D, De Smet K, Herroelen P, Gryspeerdt S and Martens GA: Serum 25(OH)D level on hospital admission associated with COVID-19 stage and mortality. Am J Clin Pathol. Nov 25–2020.Epub ahead of print. PubMed/NCBI | |
|
Ling SF, Broad E, Murphy R, Pappachan JM, Pardesi-Newton S, Kong MF and Jude EB: High-dose cholecalciferol booster therapy is associated with a reduced risk of mortality in patients with COVID-19: A cross-sectional multi-centre observational study. Nutrients. 12:37992020. View Article : Google Scholar : | |
|
Faniyi AA, Lugg ST, Faustini SE, Webster C, Duffy JE, Hewison M, Shields A, Nightingale P, Richter AG and Thickett DR: Vitamin D status and seroconversion for COVID-19 in UK healthcare workers. Eur Respir J. Dec 10–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
|
Ye K, Tang F, Liao X, Shaw B A, Deng M, Huang G, Qin Z, Peng X, Xiao H, Chen C, et al: Does serum vitamin D level affect COVID-19 infection and its severity?-A case-control study. J Am Coll Nutr. Oct 13–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
|
Jain A, Chaurasia R, Sengar NS, Singh M, Mahor S and Narain S: Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Sci Rep. 10:201912020. View Article : Google Scholar : PubMed/NCBI | |
|
Cereda E, Bogliolo L, Klersy C, Lobascio F, Masi S, Crotti S, De Stefano L, Bruno R, Corsico AG, Di Sabatino A, et al: Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital. Clin Nutr. Nov 2–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
|
Annweiler C, Hanotte B, Grandin de l'Eprevier C, Sabatier JM, Lafaie L and Célarier T: Vitamin D and survival in COVID-19 patients: A quasi-experimental study. J Steroid Biochem Mol Biol. 204:1057712020. View Article : Google Scholar : PubMed/NCBI | |
|
Annweiler G, Corvaisier M, Gautier J, Dubée V, Legrand E, Sacco G and Annweiler C: Vitamin D supplementation associated to better survival in hospitalized frail elderly COVID-19 patients: The GERIA-COVID Quasi-experimental study. Nutrients. 12:33772020. View Article : Google Scholar : | |
|
Entrenas Castillo M, Entrenas Costa LM, Vaquero Barrios JM, Alcala Diaz JF, Lopez Miranda J, Bouillon R and Quesada Gomez JM: 'Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study'. J Steroid Biochem Mol Biol. 203:1057512020. View Article : Google Scholar | |
|
Rastogi A, Bhansali A, Khare N, Suri V, Yaddanapudi N, Sachdeva N, Puri GD and Malhotra P: Short term, high-dose vitamin D supplementation for COVID-19 disease: A randomised, placebo-controlled, study (SHADE study). Postgrad Med J. Nov 12–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
|
Pereira M, Dantas Damascena A, Galvâo Azevedo LM, de Almeida Oliveira T and da Mota Santana J: Vitamin D deficiency aggravates COVID-19: Systematic review and meta-analysis. Crit Rev Food Sci Nutr. Nov 4–2020.Epub ahead of print. View Article : Google Scholar | |
|
Liu N, Sun J, Wang X, Zhang T, Zhao M and Li H: Low vitamin D status is associated with coronavirus disease 2019 outcomes: A systematic review and meta-analysis. Int J Infect Dis. 104:58–64. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Shoenfeld Y, Giacomelli R, Azrielant S, Berardicurti O, Reynolds JA and Bruce IN: Vitamin D and systemic lupus erythe-matosus-the hype and the hope. Autoimmun Rev. 17:19–23. 2018. View Article : Google Scholar | |
|
Cantorna MT, Snyder L, Lin YD and Yang L: Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients. 7:3011–3021. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang YG, Wu S and Sun J: Vitamin D, vitamin D receptor, and tissue barriers. Tissue Barriers. 1:e231182013. View Article : Google Scholar : PubMed/NCBI | |
|
Ware LB and Matthay MA: Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Git care Med. 163:1376–1383. 2001. View Article : Google Scholar | |
|
Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG and Calfee Cs: Acute respiratory distress syndrome. Nat Rev Dis Primers. 5:182019. View Article : Google Scholar : PubMed/NCBI | |
|
Campbell HK, Maiers JL and DeMali KA: Interplay between tight junctions & adherens junctions. Exp cell Res. 358:39–44. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Chen H, Lu R, Zhang YG and Sun J: Vitamin D receptor deletion leads to the destruction of tight and adherens junctions in lungs. Tissue Barriers. 6:1–13. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Shi YY, Liu TJ, Fu JH, Xu W, Wu LL, Hou AN and Xue XD: Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier. Mol Med Rep. 13:1186–1194. 2016. View Article : Google Scholar : | |
|
Sassi F, Tamone C and D'Amelio P: Vitamin D: Nutrient, hormone, and immunomodulator. Nutrients. 10:16562018. View Article : Google Scholar : | |
|
Hewison M: Antibacterial effects of vitamin D. Nat Rev Endocrinol. 7:337–345. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wei R and Christakos S: Mechanisms underlying the regulation of innate and adaptive immunity by vitamin D. Nutrients. 7:8251–8260. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Chung C, Silwal P, Kim I, Modlin RL and Jo EK: Vitamin D-cathelicidin axis: At the crossroads between protective immunity and pathological inflammation during infection. Immune Netw. 20:e122020. View Article : Google Scholar : PubMed/NCBI | |
|
Svensson D, Nebel D, Voss U, Ekblad E and Nilsson BO: Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor a. cell Tissue Res. 366:353–362. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Schrumpf JA, van Sterkenburg MA, Verhoosel RM, Zuyderduyn S and Hiemstra PS: Interleukin 13 exposure enhances vitamin D-mediated expression of the human cathelicidin antimicrobial peptide 18/LL-37 in bronchial epithelial cells. Infect Immun. 80:4485–4494. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kim EW, Teles RMB, Haile S, Liu PT and Modlin RL: Vitamin D status contributes to the antimicrobial activity of macrophages against mycobacterium leprae. PLoS Negl Trop Dis. 12:e00066082018. View Article : Google Scholar : PubMed/NCBI | |
|
Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, et al: Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med. 3:104ra1022011. View Article : Google Scholar : PubMed/NCBI | |
|
Martineau AR, Wilkinson KA, Newton SM, Floto RA, Norman AW, Skolimowska K, Davidson RN, Sørensen OE, Kampmann B, Griffiths CJ and Wilkinson RJ: IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: The role of cathelicidin LL-37. J Immunol. 178:7190–7198. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Piemonti L, Monti P, Sironi M, Fraticelli P, Leone BE, Dal cin E, Allavena P and Di carlo V: Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells. J Immunol. 164:4443–4451. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Széles L, Keresztes G, Töröcsik D, Balajthy Z, Krenacs L, Poliska S, Steinmeyer A, Zuegel U, Pruenster M, Rot A and Nagy L: 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype. J Immunol. 182:2074–2083. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Aranow C: Vitamin D and the immune system. J Investig Med. 59:881–886. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Prietl B, Treiber G, Pieber TR and Amrein K: Vitamin D and immune function. Nutrients. 5:2502–2521. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Alroy I, Towers TL and Freedman LP: Transcriptional repression of the interleukin-2 gene by vitamin D3: Direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol Cell Biol. 15:5789–5799. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Cippitelli M and Santoni A: Vitamin D3: A transcriptional modulator of the interferon-gamma gene. Eur J Immunol. 28:3017–3030. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM and Weaver CT: Lineage-specific effects of 1.25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J Biol Chem. 286:997–1004. 2011. View Article : Google Scholar | |
|
Dankers W, Colin EM, van Hamburg JP and Lubberts E: Vitamin D in autoimmunity: molecular mechanisms and therapeutic potential. Front Immunol. 7:6972017. View Article : Google Scholar : PubMed/NCBI | |
|
Tang J, Zhou R, Luger D, Zhu W, Silver PB, Grajewski RS, Su SB, Chan CC, Adorini L and Caspi RR: Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol. 182:4624–4632. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Wöbke TK, Sorg BL and Steinhilber D: Vitamin D in inflammatory diseases. Front Physiol. 5:2442014.PubMed/NCBI | |
|
Cohen-Lahav M, Shany S, Tobvin D, Chaimovitz C and Douvdevani A: Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels. Nephrol Dial Transplant. 21:889–897. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Harant H, Wolff B and Lindleyl J: 1Alpha,25-dihydroxyvitaminD3 decreases DNA binding of nuclear factor-kappa B in human fibroblasts. FEBS Lett. 436:329–334. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Sloka S, Silva C, Wang J and Yong VW: Predominance of Th2 polarization by vitamin D through a STAT6-dependent mechanism. J Neuroinflammation. 8:562011. View Article : Google Scholar : PubMed/NCBI | |
|
Calton EK, Keane KN, Newsholme P and Soares MJ: The impact of vitamin D levels on inflammatory status: A systematic review of immune cell studies. PLoS One. 10:e01417702015. View Article : Google Scholar : PubMed/NCBI | |
|
Ho IC, Tai TS and Pai SY: GATA3 and the T-cell lineage: Essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9:125–135. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Baeke F, Takiishi T, Korf H, Gysemans C and Mathieu C: Vitamin D: Modulator of the immune system. Curr Opin Pharmacol. 10:482–496. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Joshi S, Pantalena LC, Liu XK, Gaffen SL, Liu H, Rohowsky-Kochan C, Ichiyama K, Yoshimura A, Steinman L, Christakos S and Youssef S: 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol. 31:3653–3669. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Jeffery LE, Burke F, Mura M, Zheng Y, Qureshi OS, Hewison M, Walker LS, Lammas DA, Raza K and Sansom DM: 1.25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol. 183:5458–5467. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Nanduri R, Mahajan S, Bhagyaraj E, Sethi K, Kalra R, Chandra V and Gupta P: The active form of vitamin D transcriptionally represses Smad7 signaling and activates extracellular signal-regulated kinase (ERK) to inhibit the differentiation of a inflammatory T helper cell subset and suppress experimental autoimmune encephalomyelitis. J Biol Chem. 290:12222–12236. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li YC: Vitamin D regulation of the renin-angiotensin system. J Cell Biochem. 88:327–331. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Fountain JH and Lappin SL: Physiology, Renin Angiotensin System. StatPearls Publishing; Treasure Island, FL: 2020 | |
|
Mahmudpour M, Roozbeh J, Keshavarz M, Farrokhi S and Nabipour I: COVID-19 cytokine storm: The anger of inflammation. Cytokine. 133:1551512020. View Article : Google Scholar : PubMed/NCBI | |
|
Aygun H: Vitamin D can prevent COVID-19 infection-induced multiple organ damage. Naunyn Schmiedebergs Arch Pharmacol. 393:1157–1160. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ajabshir S, Asif A and Nayer A: The effects of vitamin D on the renin-angiotensin system. J Nephropathol. 3:41–43. 2014.PubMed/NCBI | |
|
Yuan W, Pan W, Kong J, Zheng W, Szeto FL, Wong KE, Cohen R, Klopot A, Zhang Z and Li YC: 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem. 282:29821–29830. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Melamed ML, Michos ED, Post W and Astor B: 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 168:1629–1637. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Cashman KD, van den Heuvel EG, Schoemaker RJ, Preveraud DP, Macdonald HM and Arcot J: 25-Hydroxyvitamin D as a biomarker of vitamin D status and its modeling to inform strategies for prevention of vitamin D deficiency within the population. Adv Nutr. 8:947–957. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Norval M and Wulf HC: Does chronic sunscreen use reduce vitamin D production to insufficient levels? Br J Dermatol. 161:732–736. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Neale RE, Khan SR, Lucas RM, Waterhouse M, Whiteman DC and Olsen CM: The effect of sunscreen on vitamin D: A review. Br J Dermatol. 181:907–915. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Brenner M and Hearing VJ: The protective role of melanin against UV damage in human skin. Photochem Photobiol. 84:539–549. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Vranic L, Mikolasevic I and Milic S: Vitamin D deficiency: Consequence or cause of obesity? Medicina (Kaunas). 55:5412019. View Article : Google Scholar | |
|
Iruzubieta P, Teran A, Crespo J and Fabrega E: Vitamin D deficiency in chronic liver disease. World J Hepatol. 6:901–915. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Goldstein DA, Haldimann B, Sherman D, Norman AW and Massry SG: Vitamin D metabolites and calcium metabolism in patients with nephrotic syndrome and normal renal function. J clin Endocrinol Metab. 52:116–121. 1981. View Article : Google Scholar : PubMed/NCBI | |
|
Banerjee S, Basu S, Akhtar S, Sinha R, Sen A and Sengupta J: Free vitamin D levels in steroid-sensitive nephrotic syndrome and healthy controls. Pediatr Nephrol. 35:447–454. 2020. View Article : Google Scholar | |
|
Skversky AL, Kumar J, Abramowitz MK, Kaskel FJ and Melamed ML: Association of glucocorticoid use and low 25-hydroxyvitamin D levels: Results from the national health and nutrition examination survey (NHANEs): 2001-2006. J Clin Endocrinol Metab. 96:3838–3845. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Fernandez H, Mohammed HT and Patel T: Vitamin D supplementation for bone health in adults with epilepsy: A systematic review. Epilepsia. 59:885–896. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou C, Assem M, Tay JC, Watkins PB, Blumberg B, Schuetz EG and Thummel KE: steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates cYP24 expression and drug-induced osteomalacia. J Clin Invest. 116:1703–1712. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Al-Badr W and Martin KJ: Vitamin D and Kidney Disease. Clin J Am Soc Nephrol. 3:1555–1560. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Chung S, Kim M, Koh ES, Hwang HS, Chang YK, Park CW, Kim SY, Chang YS and Hong YA: serum 1,25-dihydroxyvitamin D better reflects renal parameters than 25-hydoxyvitamin D in patients with glomerular diseases. Int J Med Sci. 14:1080–1087. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Dastani Z, Li R and Richards B: Genetic regulation of vitamin D levels. Calcif Tissue Int. 92:106–117. 2013. View Article : Google Scholar | |
|
Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, streeten EA, Ohlsson C, Koller DL, et al: Common genetic determinants of vitamin D insufficiency: A genome-wide association study. Lancet. 376:180–188. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Alshahrani FM, Almalki MH, Aljohani N, Alzahrani A, Alsaleh Y and Holick MF: Vitamin D: Light side and best time of sunshine in Riyadh, audi Arabia. Dermatoendocrinol. 5:177–180. 2013. View Article : Google Scholar | |
|
Gallagher JC: Vitamin D and aging. Endocrinol Metab Clin North Am. 42:319–332. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Margulies SL, Kurian D, Elliott MS and Han Z: Vitamin D deficiency in patients with intestinal malabsorption syndromes-think in and outside the gut. J Dig Dis. 16:617–633. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Robien K, Oppeneer SJ, Kelly JA and Hamilton-Reeves JM: Drug-vitamin D interactions: A systematic review of the literature. Nutr Clin Pract. 28:194–208. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Cembranel F, D'Orsi E, Jakovljevic Pudla Wagner K, Weber Corseuil Giehl M, Moreno YMF and Gonzalez-Chica DA: Obesity and 25(OH)D serum concentration are more important than vitamin D intake for changes in nutritional status indicators: A population-based longitudinal study in a state capital city in Southern Brazil. Nutrients. 11:23662019. View Article : Google Scholar : | |
|
Martrnez-Zavala N, Löpez-Sanchez GN, Vergara-Lopez A, Chavez-Tapia NC, Uribe M and Nuno-Lambarri N: Vitamin D deficiency in Mexicans have a high prevalence: A cross-sectional analysis of the patients from the centro Médico Nacional 20 de Noviembre. Arch Osteoporos. 15:882020. View Article : Google Scholar | |
|
Tomaino K, Romero KM, Robinson CL, Baumann LM, Hansel NN, Pollard SL, Gilman RH, Mougey E, Lima JJ and Checkley W; PURA study investigators: Association between serum 25-hydroxy vitamin D levels and blood pressure among adolescents in two resource-limited settings in Peru. Am J Hypertens. 28:1017–1023. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Solis-Urra P, Cristi-Montero C, Romero-Parra J, Zavala-Crichton JP, Saez-Lara MJ and Plaza-Diaz J: Passive commuting and higher sedentary time is associated with vitamin D deficiency in adult and older women: Results from Chilean national health survey 2016-2017. Nutrients. 11:3002019. View Article : Google Scholar | |
|
Hernando VU, Andry MM, Maria Virginia PF and Valentina A: Vitamin D nutritional status in the adult population in Colombia-an analytical cross-sectional study. Heliyon. 6:e034792020. View Article : Google Scholar | |
|
Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, et al: The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine What clinicians need to know. J Clin Endocrinol Metab. 96:53–58. 2011. View Article : Google Scholar | |
|
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM and Endocrine Society: Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 96:1911–1930. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Palacios C and Gonzalez L: Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 144:138–145. 2014. View Article : Google Scholar | |
|
Dobson R, Cock HR, Brex P and Giovannoni G: Vitamin D supplementation. Pract Neurol. 18:35–42. 2018. View Article : Google Scholar | |
|
EFSA Panel on Dietetic Products Nutrition and Allergies (NDA): Scientific opinion on the tolerable upper intake level of vitamin D. EFSA J. 10:28132012. | |
|
Scientific Advisory Committee on Nutrition: Vitamin D and Health. 2016. | |
|
Ebadi M and Montano-Loza AJ: Perspective: Improving vitamin D status in the management of COVID-19. Eur J Clin Nutr. 74:856–859. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Maeda SS, Borba VZ, Camargo MB, Silva DM, Borges JL, Bandeira F and Lazaretti-Castro M: Recomendaçôes da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnostico e tratamento da hipovitaminose D. Arq Bras Endocrinol Metabol. 58:411–433. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ministerio de Salud del Gobierno de Chile: Estudio para revision y actualization de las guias alimentarias para la poblacion chilena. 2013. | |
|
Vasquez-Awad D, Cano-Gutiérrez CA, Gomez-Ortiz A, Gonzalez MA, Guzman-Moreno R, Martinez-Reyes JI, Rosero-Olarte O, Rueda-Beltz C and Acosta-Reyes JL: Vitamina D. Consenso colombiano de expertos. Medicina. 39:140–157. 2017. | |
|
Lopez-Gonzalez D, Méndez-Sanchez L, Guagnelli MA and Clark P: Deficiencia de vitamina D en la edad pediatrica. una oportunidad de prevencion. Bol Med Hosp Infant Mex. 72:225–234. 2015. | |
|
Pludowski P, Holick MF, Grant WB, Konstantynowicz J, Mascarenhas MR, Haq A, Povoroznyuk V, Balatska N, Barbosa AP, Karonova T, et al: Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol. 175:125–135. 2018. View Article : Google Scholar | |
|
Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL and Bhattoa HP: Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 12:9882020. View Article : Google Scholar : | |
|
Goddek S: Vitamin D3 and K2 and their potential contribution to reducing the COVID-19 mortality rate. Int J Infect Dis. 99:286–290. 2020. View Article : Google Scholar : PubMed/NCBI |
