Open Access

Overview of the immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review)

  • Authors:
    • Tao Yang
    • Huaying Huang
    • Longfeng Jiang
    • Jun Li
  • View Affiliations

  • Published online on: July 15, 2022     https://doi.org/10.3892/ijmm.2022.5174
  • Article Number: 118
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Severe fever with thrombocytopenia syndrome (SFTS) has been acknowledged as an emerging infectious disease that is caused by the SFTS virus (SFTSV). The main clinical features of SFTS on presentation include fever, thrombocytopenia, leukocytopenia and gastrointestinal symptoms. The mortality rate is estimated to range between 5‑30% in East Asia. However, SFTSV infection is increasing on an annual basis globally and is becoming a public health problem. The transmission cycle of SFTSV remains poorly understood, which is compounded by the pathogenesis of SFTS not being fully elucidated. Since the mechanism underlying the host immune response towards SFTSV is also unclear, there are no effective vaccines or specific therapeutic agents against SFTS, with supportive care being the only realistic option. Therefore, it is now crucial to understand all aspects of the host‑virus interaction following SFTSV infection, including the antiviral states and viral evasion mechanisms. In the present review, recent research progress into the possible host immune responses against SFTSV was summarized, which may be useful in designing novel therapeutics against SFTS.
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September-2022
Volume 50 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Yang T, Huang H, Jiang L and Li J: Overview of the immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review). Int J Mol Med 50: 118, 2022.
APA
Yang, T., Huang, H., Jiang, L., & Li, J. (2022). Overview of the immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review). International Journal of Molecular Medicine, 50, 118. https://doi.org/10.3892/ijmm.2022.5174
MLA
Yang, T., Huang, H., Jiang, L., Li, J."Overview of the immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review)". International Journal of Molecular Medicine 50.3 (2022): 118.
Chicago
Yang, T., Huang, H., Jiang, L., Li, J."Overview of the immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review)". International Journal of Molecular Medicine 50, no. 3 (2022): 118. https://doi.org/10.3892/ijmm.2022.5174