Open Access

Physiological and pathological roles of Hic‑5 in several organs (Review)

  • Authors:
    • Shun Yao
    • Zhen Tu
    • Xingyue Yang
    • Li Zhang
    • Yuling Zhong
    • Liming Zheng
    • Hui Wang
    • Zhiqiang Yi
    • Jiaxing An
    • Hai Jin
    • Guorong Wen
    • Biguang Tuo
  • View Affiliations

  • Published online on: October 10, 2022     https://doi.org/10.3892/ijmm.2022.5194
  • Article Number: 138
  • Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Integrins allow cells to adhere to the extracellular matrix and promote the recruitment of other integrins, resulting in the formation of focal adhesion sites at the binding sites. Focal adhesion sites play essential roles in the assembly of the cytoskeleton and are vital in shaping the structure of cells. They also play other regulatory roles by influencing numerous biological functions, such as cell proliferation and apoptosis. Hydrogen peroxide‑inducible clone 5 (Hic‑5) is a member of the Paxillin family of proteins and is an adhesive plaque scaffolding protein. Its expression can be detected in both vascular and smooth muscle cells. Thus, it plays an essential role in vascular remodeling, as well as in fibrotic diseases. Hic‑5 functions as a coactivator of steroid receptors, thus playing a role in steroid hormone‑dependent diseases. It also plays a vital role in the invasive metastasis of various types of cancer. Moreover, several studies have demonstrated that Hic‑5 plays a critical role in transcriptional regulation, as well as in numerous signaling pathways. Therefore, the inhibition of the functions of Hic‑5 may prevent the development or halt the progression of several diseases. Its use as a therapeutic target in future investigations may thus aid in the treatment of several diseases, including various types of cancer. The present review article focused on the expression and functions of Hic‑5 in different organs, with the aim of highlighting novel possibilities for future research.
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November-2022
Volume 50 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Yao S, Tu Z, Yang X, Zhang L, Zhong Y, Zheng L, Wang H, Yi Z, An J, Jin H, Jin H, et al: Physiological and pathological roles of Hic‑5 in several organs (Review). Int J Mol Med 50: 138, 2022.
APA
Yao, S., Tu, Z., Yang, X., Zhang, L., Zhong, Y., Zheng, L. ... Tuo, B. (2022). Physiological and pathological roles of Hic‑5 in several organs (Review). International Journal of Molecular Medicine, 50, 138. https://doi.org/10.3892/ijmm.2022.5194
MLA
Yao, S., Tu, Z., Yang, X., Zhang, L., Zhong, Y., Zheng, L., Wang, H., Yi, Z., An, J., Jin, H., Wen, G., Tuo, B."Physiological and pathological roles of Hic‑5 in several organs (Review)". International Journal of Molecular Medicine 50.5 (2022): 138.
Chicago
Yao, S., Tu, Z., Yang, X., Zhang, L., Zhong, Y., Zheng, L., Wang, H., Yi, Z., An, J., Jin, H., Wen, G., Tuo, B."Physiological and pathological roles of Hic‑5 in several organs (Review)". International Journal of Molecular Medicine 50, no. 5 (2022): 138. https://doi.org/10.3892/ijmm.2022.5194