Vezzani B, Carinci M, Patergnani S, Pasquin MP, Guarino A, Aziz N, Pinton P, Simonato M and Giorgi C: The Dichotomous role of inflammation in the CNS: A mitochondrial point of view. Biomolecules. 10:14372020. View Article : Google Scholar : PubMed/NCBI

Yilmaz C, Karali K, Fodelianaki G, Gravanis A, Chavakis T, Charalampopoulos I and Alexaki VI: Neurosteroids as regulators of neuroinflammation. Front Neuroendocrinol. 55:1007882019. View Article : Google Scholar : PubMed/NCBI

Fontana L, Ghezzi L, Cross AH and Piccio L: Effects of dietary restriction on neuroinflammation in neurodegenerative diseases. J Exp Med. 218:e201900862021. View Article : Google Scholar : PubMed/NCBI

Biswas K: Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation. J Neuroimmunol. 383:5781802023. View Article : Google Scholar : PubMed/NCBI

Liu A, Yu L, Li X, Zhang K, Zhang W, So KF, Tissir F, Qu Y and Zhou L: Celsr2-mediated morphological polarization and functional phenotype of reactive astrocytes in neural repair. Glia. 71:1985–2004. 2023. View Article : Google Scholar : PubMed/NCBI

Fan YY and Huo J: A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils? Neurochem Int. 148:1050802021. View Article : Google Scholar : PubMed/NCBI

Singh D: Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease. J Neuroinflammation. 19:2062022. View Article : Google Scholar : PubMed/NCBI

Gimenez MA, Sim J, Archambault AS, Klein RS and Russell JH: A tumor necrosis factor receptor 1-dependent conversation between central nervous system-specific T cells and the central nervous system is required for inflammatory infiltration of the spinal cord. Am J Pathol. 168:1200–1209. 2006. View Article : Google Scholar : PubMed/NCBI

Da Mesquita S, Fu Z and Kipnis J: The meningeal lymphatic system: A new player in neurophysiology. Neuron. 100:375–388. 2018. View Article : Google Scholar : PubMed/NCBI

Flores-Romero H, Dadsena S and Garcia-Saez AJ: Mitochondrial pores at the crossroad between cell death and inflammatory signaling. Mol Cell. 83:843–856. 2023. View Article : Google Scholar : PubMed/NCBI

Wei Y, Miao Q, Zhang Q, Mao S, Li M, Xu X, Xia X, Wei K, Fan Y, Zheng X, et al: Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage. Nat Neurosci. 26:2081–2089. 2023. View Article : Google Scholar : PubMed/NCBI

Rose J, Brian C, Woods J, Pappa A, Panayiotidis MI, Powers R and Franco R: Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival. Toxicology. 391:109–115. 2017. View Article : Google Scholar : PubMed/NCBI

Rizzuto R, De Stefani D, Raffaello A and Mammucari C: Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol. 13:566–578. 2012. View Article : Google Scholar : PubMed/NCBI

Satarker S, Bojja SL, Gurram PC, Mudgal J, Arora D and Nampoothiri M: Astrocytic glutamatergic transmission and its implications in neurodegenerative disorders. Cells. 11:11392022. View Article : Google Scholar : PubMed/NCBI

Morales-Ropero JM, Arroyo-Urea S, Neubrand VE, Martín-Oliva D, Marín-Teva JL, Cuadros MA, Vangheluwe P, Navascués J, Mata AM and Sepúlveda MR: The endoplasmic reticulum Ca(2+) -ATPase SERCA2b is upregulated in activated microglia and its inhibition causes opposite effects on migration and phagocytosis. Glia. 69:842–857. 2021. View Article : Google Scholar

Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, et al: Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. Neuron. 111:1222–1240 e1229. 2023. View Article : Google Scholar : PubMed/NCBI

Borsche M, Pereira SL, Klein C and Grünewald A: Mitochondria and Parkinson's disease: Clinical, molecular, and translational aspects. J Parkinsons Dis. 11:45–60. 2021. View Article : Google Scholar :

Hinkle JT, Patel J, Panicker N, Karuppagounder SS, Biswas D, Belingon B, Chen R, Brahmachari S, Pletnikova O, Troncoso JC, et al: STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy. Proc Natl Acad Sci USA. 119:e21188191192022. View Article : Google Scholar

Pezone A, Olivieri F, Napoli MV, Procopio A, Avvedimento EV and Gabrielli A: inflammation and DNA damage: Cause, effect or both. Nat Rev Rheumatol. 19:200–211. 2023. View Article : Google Scholar : PubMed/NCBI

Duarte JN: Neuroinflammatory mechanisms of mitochondrial dysfunction and neurodegeneration in glaucoma. J Ophthalmol. 2021:45819092021.PubMed/NCBI

Yang Y, Liu Y, Zhu J, Song S, Huang Y, Zhang W, Sun Y, Hao J, Yang X, Gao Q, et al: Neuroinflammation-mediated mitochondrial dysregulation involved in postoperative cognitive dysfunction. Free Radic Biol Med. 178:134–146. 2022. View Article : Google Scholar

Pan RY, Ma J, Kong XX, Wang XF, Li SS, Qi XL, Yan YH, Cheng J, Liu Q, Jin W, et al: Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance. Sci Adv. 5:eaau63282019. View Article : Google Scholar

Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW II and Mochly-Rosen D: Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nat Neurosci. 22:1635–1648. 2019. View Article : Google Scholar : PubMed/NCBI

Mi Y, Qi G, Vitali F, Shang Y, Raikes AC, Wang T, Jin Y, Brinton RD, Gu H and Yin F: Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration. Nat Metab. 5:445–465. 2023. View Article : Google Scholar : PubMed/NCBI

Cenini G, Rub C, Bruderek M and Voos W: Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process. Mol Biol Cell. 27:3257–3272. 2016. View Article : Google Scholar : PubMed/NCBI

Bingol B, Tea JS, Phu L, Reichelt M, Bakalarski CE, Song Q, Foreman O, Kirkpatrick DS and Sheng M: The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature. 510:370–375. 2014. View Article : Google Scholar : PubMed/NCBI

Annesley SJ and Fisher PR: Mitochondria in health and disease. Cells. 8:6802019. View Article : Google Scholar : PubMed/NCBI

Lin MT and Beal MF: Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 443:787–795. 2006. View Article : Google Scholar : PubMed/NCBI

Johnson J, Mercado-Ayon E, Mercado-Ayon Y, Dong YN, Halawani S, Ngaba L and Lynch DR: Mitochondrial dysfunction in the development and progression of neurodegenerative diseases. Arch Biochem Biophys. 702:1086982021. View Article : Google Scholar

Adebayo M, Singh S, Singh AP and Dasgupta S: Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis. FASEB J. 35:e216202021. View Article : Google Scholar : PubMed/NCBI

Alevriadou BR, Patel A, Noble M, Ghosh S, Gohil VM, Stathopulos PB and Madesh M: Molecular nature and physiological role of the mitochondrial calcium uniporter channel. Am J Physiol Cell Physiol. 320:C465–C482. 2021. View Article : Google Scholar :

Fischer R and Maier O: Interrelation of oxidative stress and inflammation in neurodegenerative disease: Role of TNF. Oxid Med Cell Longev. 2015:6108132015. View Article : Google Scholar : PubMed/NCBI

Teleanu DM, Niculescu AG, Lungu II, Radu CI, Vladâcenco O, Roza E, Costăchescu B, Grumezescu AM and Teleanu RI: An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. Int J Mol Sci. 23:59382022. View Article : Google Scholar : PubMed/NCBI

Tsang T, Davis CI and Brady DC: Copper biology. Curr Biol. 31:R421–R427. 2021. View Article : Google Scholar : PubMed/NCBI

Borisov VB, Siletsky SA, Nastasi MR and Forte E: ROS defense systems and terminal oxidases in bacteria. Antioxidants (Basel). 10:8392021. View Article : Google Scholar : PubMed/NCBI

Haider S, Batool Z, Ahmad S, Siddiqui RA and Haleem DJ: Walnut supplementation reverses the scopolamine-induced memory impairment by restoration of cholinergic function via mitigating oxidative stress in rats: A potential therapeutic intervention for age related neurodegenerative disorders. Metab Brain Dis. 33:39–51. 2018. View Article : Google Scholar

Luque-Contreras D, Carvajal K, Toral-Rios D, Franco-Bocanegra D and Campos-Pena V: Oxidative stress and metabolic syndrome: Cause or consequence of Alzheimer's disease? Oxid Med Cell Longev. 2014:4978022014. View Article : Google Scholar : PubMed/NCBI

Singh A, Kukreti R, Saso L and Kukreti S: Oxidative stress: A key modulator in neurodegenerative diseases. Molecules. 24:15832019. View Article : Google Scholar : PubMed/NCBI

Bhatia V and Sharma S: Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease. J Neurol Sci. 421:1172532021. View Article : Google Scholar : PubMed/NCBI

Zorov DB, Juhaszova M and Sollott SJ: Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 94:909–950. 2014. View Article : Google Scholar : PubMed/NCBI

Farkhondeh T, Mehrpour O, Forouzanfar F, Roshanravan B and Samarghandian S: Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: A review. Environ Sci Pollut Res Int. 27:24799–24814. 2020. View Article : Google Scholar : PubMed/NCBI

Rowley S, Liang LP, Fulton R, Shimizu T, Day B and Patel M: Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy. Neurobiol Dis. 75:151–158. 2015. View Article : Google Scholar : PubMed/NCBI

Bordoni L and Gabbianelli R: Mitochondrial DNA and neurodegeneration: Any role for dietary antioxidants? Antioxidants (Basel). 9:7642020. View Article : Google Scholar : PubMed/NCBI

Coppede F: Mitochondrial DNA methylation and mitochondria-related epigenetics in neurodegeneration. Neural Regen Res. 19:405–406. 2024. View Article : Google Scholar

Sharma VK, Singh TG and Mehta V: Stressed mitochondria: A target to intrude alzheimer's disease. Mitochondrion. 59:48–57. 2021. View Article : Google Scholar : PubMed/NCBI

Lin J and Epel E: Stress and telomere shortening: Insights from cellular mechanisms. Ageing Res Rev. 73:1015072022. View Article : Google Scholar :

Ortiz JM and Swerdlow RH: Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities. Br J Pharmacol. 176:3489–3507. 2019. View Article : Google Scholar

Liu H, Zhang H, Zhang Y, Xu S, Zhao H, He H and Liu X: Modeling mtDNA hypermethylation vicious circle mediating Aβ-induced endothelial damage memory in HCMEC/D3 cell. Aging (Albany NY). 12:18343–18362. 2020. View Article : Google Scholar : PubMed/NCBI

Rasheed M, Liang J, Wang C, Deng Y and Chen Z: Epigenetic regulation of neuroinflammation in Parkinson's disease. Int J Mol Sci. 22:49562021. View Article : Google Scholar : PubMed/NCBI

Youle RJ and van der Bliek AM: Mitochondrial fission, fusion, and stress. Science. 337:1062–1065. 2012. View Article : Google Scholar : PubMed/NCBI

Song Y, Xu Y, Liu Y, Gao J, Feng L, Zhang Y, Shi L and Zhang M, Guo D, Qi B and Zhang M: Mitochondrial quality control in the maintenance of cardiovascular homeostasis: The roles and interregulation of UPS, mitochondrial dynamics and mitophagy. Oxid Med Cell Longev. 2021:39607732021. View Article : Google Scholar : PubMed/NCBI

Xie JH, Li YY and Jin J: The essential functions of mitochondrial dynamics in immune cells. Cell Mol Immunol. 17:712–721. 2020. View Article : Google Scholar : PubMed/NCBI

Chakrabarti S and Bisaglia M: Oxidative stress and neuroinflammation in Parkinson's disease: The role of dopamine oxidation products. Antioxidants (Basel). 12:9552023. View Article : Google Scholar : PubMed/NCBI

Picca A, Ferri E, Calvani R, Coelho-Junior HJ, Marzetti E and Arosio B: Age-Associated glia remodeling and mitochondrial dysfunction in neurodegeneration: Antioxidant supplementation as a possible intervention. Nutrients. 14:24062022. View Article : Google Scholar : PubMed/NCBI

Dhapola R, Hota SS, Sarma P, Bhattacharyya A, Medhi B and Reddy DH: Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer's disease. Inflammopharmacology. 29:1669–1681. 2021. View Article : Google Scholar : PubMed/NCBI

Chang YH, Lin HY, Shen FC, Su YJ, Chuang JH, Lin TK, Liou CW, Lin CY, Weng SW and Wang PW: The causal role of mitochondrial dynamics in regulating innate immunity in diabetes. Front Endocrinol (Lausanne). 11:4452020. View Article : Google Scholar : PubMed/NCBI

Paik S, Kim JK, Silwal P, Sasakawa C and Jo EK: An update on the regulatory mechanisms of NLRP3 inflammasome activation. Cell Mol Immunol. 18:1141–1160. 2021. View Article : Google Scholar : PubMed/NCBI

Yurtsever I, Ustundag UV, Ünal I, Ateş PS and Emekli-Alturfan E: Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish. Drug Chem Toxicol. 45:1544–1551. 2022. View Article : Google Scholar

Kannurpatti SS: Mitochondrial calcium homeostasis: Implications for neurovascular and neurometabolic coupling. J Cereb Blood Flow Metab. 37:381–395. 2017. View Article : Google Scholar :

Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, Schrag AE and Lang AE: Parkinson disease. Nat Rev Dis Primers. 3:170132017. View Article : Google Scholar : PubMed/NCBI

Binvignat O and Olloquequi J: Excitotoxicity as a target against neurodegenerative processes. Curr Pharm Des. 26:1251–1262. 2020. View Article : Google Scholar : PubMed/NCBI

Yao L, Wu J, Koc S and Lu G: Genetic imaging of neuroinflammation in Parkinson's disease: Recent advancements. Front Cell Dev Biol. 9:6558192021. View Article : Google Scholar : PubMed/NCBI

Obrador E, Salvador R, Lopez-Blanch R, Jihad-Jebbar A, Valles SL and Estrela JM: Oxidative stress, neuroinflammation and mitochondria in the pathophysiology of amyotrophic lateral sclerosis. Antioxidants (Basel). 9:9012020. View Article : Google Scholar : PubMed/NCBI

Cyrino LAR, Delwing-de Lima D, Ullmann OM and Maia TP: Concepts of neuroinflammation and their relationship with impaired mitochondrial functions in bipolar disorder. Front Behav Neurosci. 15:6094872021. View Article : Google Scholar : PubMed/NCBI

Verkhratsky A, Rodriguez-Arellano JJ, Parpura V and Zorec R: Astroglial calcium signalling in Alzheimer's disease. Biochem Biophys Res Commun. 483:1005–1012. 2017. View Article : Google Scholar

Casaril AM, Katsalifis A, Schmidt RM and Bas-Orth C: Activated glia cells cause bioenergetic impairment of neurons that can be rescued by knock-down of the mitochondrial calcium uniporter. Biochem Biophys Res Commun. 608:45–51. 2022. View Article : Google Scholar : PubMed/NCBI

Garbincius JF and Elrod JW: Mitochondrial calcium exchange in physiology and disease. Physiol Rev. 102:893–992. 2022. View Article : Google Scholar :

Baumgartner HK, Gerasimenko JV, Thorne C, Ferdek P, Pozzan T, Tepikin AV, Petersen OH, Sutton R, Watson AJ and Gerasimenko OV: Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J Biol Chem. 284:20796–20803. 2009. View Article : Google Scholar : PubMed/NCBI

Green DR and Kroemer G: The pathophysiology of mitochondrial cell death. Science. 305:626–629. 2004. View Article : Google Scholar : PubMed/NCBI

Rimessi A, Previati M, Nigro F, Wieckowski MR and Pinton P: Mitochondrial reactive oxygen species and inflammation: Molecular mechanisms, diseases and promising therapies. Int J Biochem Cell Biol. 81:281–293. 2016. View Article : Google Scholar : PubMed/NCBI

Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C and Pinton P: Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death. Cell Calcium. 69:62–72. 2018. View Article : Google Scholar

Ooi K, Hu L, Feng Y, Han C, Ren X, Qian X, Huang H, Chen S, Shi Q, Lin H, et al: Sigma-1 receptor activation suppresses microglia M1 polarization via regulating endoplasmic reticulum-mitochondria contact and mitochondrial functions in stress-induced hypertension rats. Mol Neurobiol. 58:6625–6646. 2021. View Article : Google Scholar : PubMed/NCBI

Harland M, Torres S, Liu J and Wang X: Neuronal mitochondria modulation of LPS-induced neuroinflammation. J Neurosci. 40:1756–1765. 2020. View Article : Google Scholar : PubMed/NCBI

Lim D, Dematteis G, Tapella L, Genazzani AA, Calì T, Brini M and Verkhratsky A: Ca(2+) handling at the mitochondria-ER contact sites in neurodegeneration. Cell Calcium. 98:1024532021. View Article : Google Scholar : PubMed/NCBI

Krols M, van Isterdael G, Asselbergh B, Kremer A, Lippens S, Timmerman V and Janssens S: Mitochondria-associated membranes as hubs for neurodegeneration. Acta Neuropathol. 131:505–523. 2016. View Article : Google Scholar : PubMed/NCBI

Sunanda T, Ray B, Mahalakshmi AM, Bhat A, Rashan L, Rungratanawanich W, Song BJ, Essa MM, Sakharkar MK and Chidambaram SB: Mitochondria-endoplasmic reticulum crosstalk in Parkinson's disease: The role of brain renin angiotensin system components. Biomolecules. 11:16692021. View Article : Google Scholar : PubMed/NCBI

Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, et al: Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med. 14:1097–1105. 2008. View Article : Google Scholar : PubMed/NCBI

Ayabe T, Takahashi C, Ohya R and Ano Y: β-Lactolin improves mitochondrial function in Abeta-treated mouse hippocampal neuronal cell line and a human iPSC-derived neuronal cell model of Alzheimer's disease. FASEB J. 36:e222772022. View Article : Google Scholar

Reddy PH and Beal MF: Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med. 14:45–53. 2008. View Article : Google Scholar : PubMed/NCBI

Dursun E, Alaylioglu M, Bilgic B, Hanağası H, Gürvit H, Emre M and Gezen-Ak D: Amyloid beta adsorption problem with transfer plates in amyloid beta 1-42 IVD Kits. J Mol Neurosci. 67:534–539. 2019. View Article : Google Scholar : PubMed/NCBI

Han J, Park H, Maharana C, Gwon AR, Park J, Baek SH, Bae HG, Cho Y, Kim HK, Sul JH, et al: Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function. Theranostics. 11:8855–8873. 2021. View Article : Google Scholar : PubMed/NCBI

Bai R, Guo J, Ye XY, Xie Y and Xie T: Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease. Ageing Res Rev. 77:1016192022. View Article : Google Scholar : PubMed/NCBI

Kowalczyk P, Sulejczak D, Kleczkowska P, Bukowska-Ośko I, Kucia M, Popiel M, Wietrak E, Kramkowski K, Wrzosek K and Kaczyńska K: Mitochondrial oxidative stress-A causative factor and therapeutic target in many diseases. Int J Mol Sci. 22:133842021. View Article : Google Scholar : PubMed/NCBI

Park MW, Cha HW, Kim J, Kim JH, Yang H, Yoon S, Boonpraman N, Yi SS, Yoo ID and Moon JS: NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases. Redox Biol. 41:1019472021. View Article : Google Scholar : PubMed/NCBI

Islam MT: Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res. 39:73–82. 2017. View Article : Google Scholar

Simpson DSA and Oliver PL: ROS generation in microglia: Understanding oxidative stress and inflammation in neurodegenerative disease. Antioxidants (Basel). 9:7432020. View Article : Google Scholar : PubMed/NCBI

ElAli A, Bordeleau M, Theriault P, Filali M, Lampron A and Rivest S: Tissue-plasminogen activator attenuates Alzheimer's disease-related pathology development in APPswe/PS1 mice. Neuropsychopharmacology. 41:1297–1307. 2016. View Article : Google Scholar :

Li Y, Xia X, Wang Y and Zheng JC: Mitochondrial dysfunction in microglia: A novel perspective for pathogenesis of Alzheimer's disease. J Neuroinflammation. 19:2482022. View Article : Google Scholar : PubMed/NCBI

Massey N, Shrestha D, Bhat SM, Kondru N, Charli A, Karriker LA, Kanthasamy AG and Charavaryamath C: Organic dust-induced mitochondrial dysfunction could be targeted via cGAS-STING or cytoplasmic NOX-2 inhibition using microglial cells and brain slice culture models. Cell Tissue Res. 384:465–486. 2021. View Article : Google Scholar : PubMed/NCBI

Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, et al: NLRP3 inflammasome activation drives tau pathology. Nature. 575:669–673. 2019. View Article : Google Scholar : PubMed/NCBI

Kelley N, Jeltema D, Duan Y and He Y: The NLRP3 inflammasome: An overview of mechanisms of activation and regulation. Int J Mol Sci. 20:33282019. View Article : Google Scholar : PubMed/NCBI

Jassim AH, Inman DM and Mitchell CH: Crosstalk between dysfunctional mitochondria and inflammation in glaucomatous neurodegeneration. Front Pharmacol. 12:6996232021. View Article : Google Scholar : PubMed/NCBI

Shaftel SS, Griffin WS and O'Banion MK: The role of interleukin-1 in neuroinflammation and Alzheimer disease: An evolving perspective. J Neuroinflammation. 5:72008. View Article : Google Scholar : PubMed/NCBI

Gonzalez-Reyes RE, Nava-Mesa MO, Vargas-Sanchez K, Ariza-Salamanca D and Mora-Munoz L: Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective. Front Mol Neurosci. 10:4272017. View Article : Google Scholar

Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ and Griffin WS: In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging. 17:761–766. 1996. View Article : Google Scholar : PubMed/NCBI

Bossu P, Ciaramella A, Moro ML, Bellincampi L, Bernardini S, Federici G, Trequattrini A, Macciardi F, Spoletini I, Di Iulio F, et al: Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease. J Neurol Neurosurg Psychiatry. 78:807–811. 2007. View Article : Google Scholar : PubMed/NCBI

Gasser T: Molecular pathogenesis of Parkinson disease: Insights from genetic studies. Expert Rev Mol Med. 11:e222009. View Article : Google Scholar : PubMed/NCBI

Braak H, Del Tredici K, Rub U, de Vos RA, Jansen EN and Braak E: Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging. 24:197–211. 2003. View Article : Google Scholar

Han C, Liu Y, Dai R, Ismail N, Su W and Li B: Ferroptosis and its potential role in human diseases. Front Pharmacol. 11:2392020. View Article : Google Scholar : PubMed/NCBI

Panicker N, Ge P, Dawson VL and Dawson TM: The cell biology of Parkinson's disease. J Cell Biol. 220:e2020120952021. View Article : Google Scholar : PubMed/NCBI

Liu G, Zhang C, Yin J, Li X, Cheng F, Li Y, Yang H, Uéda K, Chan P and Yu S: alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity. Neurosci Lett. 454:187–192. 2009. View Article : Google Scholar : PubMed/NCBI

Thomas RR, Keeney PM and Bennett JP: Impaired complex-I mitochondrial biogenesis in Parkinson disease frontal cortex. J Parkinsons Dis. 2:67–76. 2012. View Article : Google Scholar : PubMed/NCBI

Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, et al: High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet. 38:515–517. 2006. View Article : Google Scholar : PubMed/NCBI

Valente EM, Bentivoglio AR, Dixon PH, Ferraris A, Ialongo T, Frontali M, Albanese A and Wood NW: Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36. Am J Hum Genet. 68:895–900. 2001. View Article : Google Scholar : PubMed/NCBI

Fan Z, Pan YT, Zhang ZY, Yang H, Yu SY, Zheng Y, Ma JH and Wang XM: Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease. J Neuroinflammation. 17:112020. View Article : Google Scholar

Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z and Narendra DP: Parkin and PINK1 mitigate STING-induced inflammation. Nature. 561:258–262. 2018. View Article : Google Scholar : PubMed/NCBI

Hou X, Fiesel FC, Truban D, Casey MC, Lin WL, Soto AI, Tacik P, Rousseau LG, Diehl NN, Heckman MG, et al: Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease. Autophagy. 14:1404–1418. 2018. View Article : Google Scholar : PubMed/NCBI

Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, Hu X, McCoy J, Chu CT, Burton EA, et al: α-synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease. Sci Transl Med. 8:342ra3782016. View Article : Google Scholar

Vicario M, Cieri D, Vallese F, Catoni C, Barazzuol L, Berto P, Grinzato A, Barbieri L, Brini M and Calì T: A split-GFP tool reveals differences in the sub-mitochondrial distribution of wt and mutant alpha-synuclein. Cell Death Dis. 10:8572019. View Article : Google Scholar : PubMed/NCBI

Devi L, Raghavendran V, Prabhu BM, Avadhani NG and Anandatheerthavarada HK: Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J Biol Chem. 283:9089–9100. 2008. View Article : Google Scholar : PubMed/NCBI

Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW and Lashuel HA: The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci USA. 117:4971–4982. 2020. View Article : Google Scholar

Hsieh CH, Shaltouki A, Gonzalez AE, da Cruz AB, Burbulla LF, St Lawrence E, Schüle B, Krainc D, Palmer TD and Wang X: Functional impairment in miro degradation and mitophagy is a shared feature in familial and sporadic Parkinson's disease. Cell Stem Cell. 19:709–724. 2016. View Article : Google Scholar : PubMed/NCBI

Godena VK, Brookes-Hocking N, Moller A, Shaw G, Oswald M, Sancho RM, Miller CC, Whitworth AJ and De Vos KJ: Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. Nat Commun. 5:52452014. View Article : Google Scholar : PubMed/NCBI

Bonello F, Hassoun SM, Mouton-Liger F, Shin YS, Muscat A, Tesson C, Lesage S, Bear PM, Brice A, Krupp J, et al: LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: Pathologic insights into Parkinson's disease. Hum Mol Genet. 28:1645–1660. 2019. View Article : Google Scholar : PubMed/NCBI

Wang X, Chi J, Huang D, Ding L, Zhao X, Jiang L, Yu Y and Gao F: α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome. Exp Ther Med. 19:931–938. 2020.PubMed/NCBI

Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, et al: Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinsons Dis. 3:302017. View Article : Google Scholar : PubMed/NCBI

Mouton-Liger F, Rosazza T, Sepulveda-Diaz J, Ieang A, Hassoun SM, Claire E, Mangone G, Brice A, Michel PP, Corvol JC and Corti O: Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop. Glia. 66:1736–1751. 2018. View Article : Google Scholar : PubMed/NCBI

Zhang C, Zhao M, Wang B, Su Z, Guo B, Qin L, Zhang W and Zheng R: The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of celastrol in Parkinson's disease. Redox Biol. 47:1021342021. View Article : Google Scholar : PubMed/NCBI

Faissner S, Plemel JR, Gold R and Yong VW: Progressive multiple sclerosis: From pathophysiology to therapeutic strategies. Nat Rev Drug Discov. 18:905–922. 2019. View Article : Google Scholar : PubMed/NCBI

Barcelos IP, Troxell RM and Graves JS: Mitochondrial dysfunction and multiple sclerosis. Biology (Basel). 8:372019.PubMed/NCBI

Steinman L: Multiple sclerosis: A two-stage disease. Nat Immunol. 2:762–764. 2001. View Article : Google Scholar : PubMed/NCBI

Lassmann H, van Horssen J and Mahad D: Progressive multiple sclerosis: Pathology and pathogenesis. Nat Rev Neurol. 8:647–656. 2012. View Article : Google Scholar : PubMed/NCBI

Lopez-Domenech G and Kittler JT: Mitochondrial regulation of local supply of energy in neurons. Curr Opin Neurobiol. 81:1027472023. View Article : Google Scholar : PubMed/NCBI

Touil H, Li R, Zuroff L, Moore CS, Healy L, Cignarella F, Piccio L, Ludwin S, Prat A, Gommerman J, et al: Cross-talk between B cells, microglia and macrophages, and implications to central nervous system compartmentalized inflammation and progressive multiple sclerosis. EBioMedicine. 96:1047892023. View Article : Google Scholar : PubMed/NCBI

Campbell GR, Ziabreva I, Reeve AK, Krishnan KJ, Reynolds R, Howell O, Lassmann H, Turnbull DM and Mahad DJ: Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol. 69:481–492. 2011. View Article : Google Scholar : PubMed/NCBI

Witte ME, Nijland PG, Drexhage JA, Gerritsen W, Geerts D, van Het Hof B, Reijerkerk A, de Vries HE, van der Valk P and van Horssen J: Reduced expression of PGC-1alpha partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex. Acta Neuropathol. 125:231–243. 2013. View Article : Google Scholar

Haider L, Fischer MT, Frischer JM, Bauer J, Höftberger R, Botond G, Esterbauer H, Binder CJ, Witztum JL and Lassmann H: Oxidative damage in multiple sclerosis lesions. Brain. 134:1914–1924. 2011. View Article : Google Scholar : PubMed/NCBI

Dziedzic T, Metz I, Dallenga T, König FB, Müller S, Stadelmann C and Brück W: Wallerian degeneration: A major component of early axonal pathology in multiple sclerosis. Brain Pathol. 20:976–985. 2010. View Article : Google Scholar : PubMed/NCBI

Madsen PM, Pinto M, Patel S, McCarthy S, Gao H, Taherian M, Karmally S, Pereira CV, Dvoriantchikova G, Ivanov D, et al: Mitochondrial DNA double-strand breaks in oligodendrocytes cause demyelination, axonal injury, and CNS inflammation. J Neurosci. 37:10185–10199. 2017. View Article : Google Scholar : PubMed/NCBI

Singhal NK, Alkhayer K, Shelestak J, Clements R, Freeman E and McDonough J: Erythropoietin upregulates brain hemoglobin expression and supports neuronal mitochondrial activity. Mol Neurobiol. 55:8051–8058. 2018. View Article : Google Scholar : PubMed/NCBI

Aboul-Enein F, Krssak M, Hoftberger R, Prayer D and Kristoferitsch W: Reduced NAA-levels in the NAWM of patients with MS is a feature of progression. A study with quantitative magnetic resonance spectroscopy at 3 tesla. PLoS One. 5:e116252010. View Article : Google Scholar : PubMed/NCBI

Dominicis A, Del Giovane A, Torreggiani M, Recchia AD, Ciccarone F, Ciriolo MR and Ragnini-Wilson A: N-Acetylaspartate drives oligodendroglial differentiation via histone deacetylase activation. Cells. 12:18612023. View Article : Google Scholar : PubMed/NCBI

Kadowaki A and Quintana FJ: The NLRP3 inflammasome in progressive multiple sclerosis. Brain. 143:1286–1288. 2020. View Article : Google Scholar : PubMed/NCBI

Ferecsko AS, Smallwood MJ, Moore A, Liddle C, Newcombe J, Holley J, Whatmore J, Gutowski NJ and Eggleton P: STING-triggered CNS inflammation in human neurodegenerative diseases. Biomedicines. 11:13752023. View Article : Google Scholar : PubMed/NCBI

Thijs RD, Surges R, O'Brien TJ and Sander JW: Epilepsy in adults. Lancet. 393:689–701. 2019. View Article : Google Scholar : PubMed/NCBI

Fabisiak T and Patel M: Crosstalk between neuroinflammation and oxidative stress in epilepsy. Front Cell Dev Biol. 10:9769532022. View Article : Google Scholar : PubMed/NCBI

Loscher W and Klein P: The pharmacology and clinical efficacy of antiseizure medications: From bromide salts to cenobamate and beyond. CNS Drugs. 35:935–963. 2021. View Article : Google Scholar : PubMed/NCBI

Pearson-Smith JN and Patel M: Metabolic dysfunction and oxidative stress in epilepsy. Int J Mol Sci. 18:23652017. View Article : Google Scholar : PubMed/NCBI

Geronzi U, Lotti F and Grosso S: Oxidative stress in epilepsy. Expert Rev Neurother. 18:427–434. 2018. View Article : Google Scholar : PubMed/NCBI

Terrone G, Balosso S, Pauletti A, Ravizza T and Vezzani A: Inflammation and reactive oxygen species as disease modifiers in epilepsy. Neuropharmacology. 167:1077422020. View Article : Google Scholar

Ahras-Sifi N and Laraba-Djebari F: Immunomodulatory and protective effects of interleukin-4 on the neuropathological alterations induced by a potassium channel blocker. J Neuroimmunol. 355:5775492021. View Article : Google Scholar : PubMed/NCBI

Rahman S: Pathophysiology of mitochondrial disease causing epilepsy and status epilepticus. Epilepsy Behav. 49:71–75. 2015. View Article : Google Scholar : PubMed/NCBI

Liang LP, Waldbaum S, Rowley S, Huang TT, Day BJ and Patel M: Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin. Neurobiol Dis. 45:1068–1076. 2012. View Article : Google Scholar :

Fulton RE, Pearson-Smith JN, Huynh CQ, Fabisiak T, Liang LP, Aivazidis S, High BA, Buscaglia G, Corrigan T, Valdez R, et al: Neuron-specific mitochondrial oxidative stress results in epilepsy, glucose dysregulation and a striking astrocyte response. Neurobiol Dis. 158:1054702021. View Article : Google Scholar : PubMed/NCBI

Zhang S, Chen F, Zhai F and Liang S: Role of HMGB1/TLR4 and IL-1β/IL-1R1 signaling pathways in epilepsy. Front Neurol. 13:9042252022. View Article : Google Scholar

Kim JE and Kang TC: Differential roles of mitochondrial translocation of active caspase-3 and HMGB1 in neuronal death induced by status epilepticus. Front Cell Neurosci. 12:3012018. View Article : Google Scholar : PubMed/NCBI

Hyun HW, Ko AR and Kang TC: Mitochondrial translocation of high mobility group box 1 facilitates LIM kinase 2-mediated programmed necrotic neuronal death. Front Cell Neurosci. 10:992016. View Article : Google Scholar : PubMed/NCBI

Kim JE, Park H, Kim TH and Kang TC: LONP1 regulates mitochondrial accumulations of HMGB1 and Caspase-3 in CA1 and PV neurons following status epilepticus. Int J Mol Sci. 22:22752021. View Article : Google Scholar : PubMed/NCBI

Pauletti A, Terrone G, Shekh-Ahmad T, Salamone A, Ravizza T, Rizzi M, Pastore A, Pascente R, Liang LP, Villa BR, et al: Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy. Brain. 142:e392019. View Article : Google Scholar : PubMed/NCBI

Kumar P, Osahon OW and Sekhar RV: GlyNAC (Glycine and N-Acetylcysteine) supplementation in mice increases length of life by correcting glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormalities in mitophagy and nutrient sensing, and genomic damage. Nutrients. 14:11142022. View Article : Google Scholar : PubMed/NCBI

Mohseni-Moghaddam P, Roghani M, Khaleghzadeh-Ahangar H, Sadr SS and Sala C: A literature overview on epilepsy and inflammasome activation. Brain Res Bull. 172:229–235. 2021. View Article : Google Scholar : PubMed/NCBI

Abais JM, Zhang C, Xia M, Liu Q, Gehr TW, Boini KM and Li PL: NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia. Antioxid Redox Signal. 18:1537–1548. 2013. View Article : Google Scholar :

Subramanian N, Natarajan K, Clatworthy MR, Wang Z and Germain RN: The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell. 153:348–361. 2013. View Article : Google Scholar : PubMed/NCBI

Zhou R, Yazdi AS, Menu P and Tschopp J: A role for mitochondria in NLRP3 inflammasome activation. Nature. 469:221–225. 2011. View Article : Google Scholar

Rong S, Wan D, Fan Y, Liu S, Sun K, Huo J, Zhang P, Li X, Xie X, Wang F and Sun T: Amentoflavone affects epileptogenesis and exerts neuroprotective effects by inhibiting NLRP3 inflammasome. Front Pharmacol. 10:8562019. View Article : Google Scholar : PubMed/NCBI

Liu Z, Xian H, Ye X, Chen J, Ma Y and Huang W: Increased levels of NLRP3 in children with febrile seizures. Brain Dev. 42:336–341. 2020. View Article : Google Scholar : PubMed/NCBI

de Brito Toscano EC, Vieira EL, Dias BB, Caliari MV, Gonçalves AP, Giannetti AV, Siqueira JM, Suemoto CK, Leite RE, Nitrini R, et al: NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-β in sclerotic hippocampi. Brain Res. 1752:1472302021. View Article : Google Scholar

Tan CC, Zhang JG, Tan MS, Chen H, Meng DW, Jiang T, Meng XF, Li Y, Sun Z, Li MM, et al: NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model. J Neuroinflammation. 12:182015. View Article : Google Scholar : PubMed/NCBI

Samidurai M, Tarale P, Janarthanam C, Estrada CG, Gordon R, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG and Kanthasamy A: tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances activation of STAT3/NLRC4 inflammasome signaling axis through PKCdelta in AStrocytes: Implications for Parkinson's disease. Cells. 9:18312020. View Article : Google Scholar

Zadori D, Klivenyi P, Szalardy L, Fulop F, Toldi J and Vecsei L: Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders. J Neurol Sci. 322:187–191. 2012. View Article : Google Scholar : PubMed/NCBI

Prasuhn J, Davis RL and Kumar KR: Targeting mitochondrial impairment in Parkinson's disease: Challenges and opportunities. Front Cell Dev Biol. 8:6154612020. View Article : Google Scholar

Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Van Meensel S, Schaap O, De Strooper B, Meganathan R, et al: Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science. 336:1306–1310. 2012. View Article : Google Scholar : PubMed/NCBI

Bronzuoli MR, Iacomino A, Steardo L and Scuderi C: Targeting neuroinflammation in Alzheimer's disease. J Inflamm Res. 9:199–208. 2016. View Article : Google Scholar : PubMed/NCBI

Fu AK, Hung KW, Yuen MY, Zhou X, Mak DS, Chan IC, Cheung TH, Zhang B, Fu WY, Liew FY and Ip NY: IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Proc Natl Acad Sci USA. 113:E2705–E2713. 2016. View Article : Google Scholar : PubMed/NCBI

Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, Xie Z, Chu X, Yang J, Wang H, et al: Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. 29:787–803. 2019. View Article : Google Scholar : PubMed/NCBI

Regen F, Hellmann-Regen J, Costantini E and Reale M: Neuroinflammation and Alzheimer's disease: Implications for microglial activation. Curr Alzheimer Res. 14:1140–1148. 2017. View Article : Google Scholar : PubMed/NCBI

La Torre ME, Cianciulli A, Monda V, Monda M, Filannino FM, Antonucci L, Valenzano A, Cibelli G, Porro C, Messina G, et al: α-Tocopherol protects lipopolysaccharide-activated BV2 microglia. Molecules. 28:33402023. View Article : Google Scholar

Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA and Mohan G: Neuroinflammation pathways: A general review. Int J Neurosci. 127:624–633. 2017. View Article : Google Scholar

Heger LM, Wise RM, Hees JT, Harbauer AB and Burbulla LF: Mitochondrial phenotypes in Parkinson's diseases-a focus on human iPSC-derived dopaminergic neurons. Cells. 10:34362021. View Article : Google Scholar : PubMed/NCBI

Yu G, Wang Y and Zhao J: Inhibitory effect of mitoquinone against the α-synuclein fibrillation and relevant neurotoxicity: Possible role in inhibition of Parkinson's disease. Biol Chem. 403:253–263. 2022. View Article : Google Scholar

Snow BJ, Rolfe FL, Lockhart MM, Frampton CM, O'Sullivan JD, Fung V, Smith RA, Murphy MP and Taylor KM; Protect Study Group: A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord. 25:1670–1674. 2010. View Article : Google Scholar : PubMed/NCBI

Lehmann S, Loh SH and Martins LM: Enhancing NAD(+) salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease. Biol Open. 6:141–147. 2017.

Monti DA, Zabrecky G, Kremens D, Liang TW, Wintering NA, Bazzan AJ, Zhong L, Bowens BK, Chervoneva I, Intenzo C and Newberg AB: N-Acetyl cysteine is associated with dopaminergic improvement in Parkinson's disease. Clin Pharmacol Ther. 106:884–890. 2019. View Article : Google Scholar : PubMed/NCBI

Sathe AG, Tuite P, Chen C, Ma Y, Chen W, Cloyd J, Low WC, Steer CJ, Lee BY, Zhu XH and Coles LD: Pharmacokinetics, safety, and tolerability of orally administered ursodeoxycholic acid in patients with Parkinson's disease-a pilot study. J Clin Pharmacol. 60:744–750. 2020. View Article : Google Scholar : PubMed/NCBI

Bell SM, Barnes K, Clemmens H, Al-Rafiah AR, Al-Ofi EA, Leech V, Bandmann O, Shaw PJ, Blackburn DJ, Ferraiuolo L and Mortiboys H: Ursodeoxycholic acid improves mitochondrial function and redistributes Drp1 in fibroblasts from patients with either sporadic or familial Alzheimer's Disease. J Mol Biol. 430:3942–3953. 2018. View Article : Google Scholar : PubMed/NCBI

Lin MW, Lin CC, Chen YH, Yang HB and Hung SY: Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy. Antioxidants (Basel). 9:372019. View Article : Google Scholar

Bido S, Soria FN, Fan RZ, Bezard E and Tieu K: Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease. Sci Rep. 7:74952017. View Article : Google Scholar

Curtis WM, Seeds WA, Mattson MP and Bradshaw PC: NADPH and mitochondrial quality control as targets for a circadian-based fasting and exercise therapy for the treatment of Parkinson's disease. Cells. 11:24162022. View Article : Google Scholar : PubMed/NCBI

Ferreira AFF, Binda KH, Singulani MP, Pereira CPM, Ferrari GD, Alberici LC, Real CC and Britto LR: Physical exercise protects against mitochondria alterations in the 6-hidroxydopamine rat model of Parkinson's disease. Behav Brain Res. 387:1126072020. View Article : Google Scholar : PubMed/NCBI

Kappos L, Bar-Or A, Cree BAC, Fox RJ, Giovannoni G, Gold R, Vermersch P, Arnold DL, Arnould S, Scherz T, et al: Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): A double-blind, randomised, phase 3 study. Lancet. 391:1263–1273. 2018. View Article : Google Scholar : PubMed/NCBI

Montalban X, Hauser SL, Kappos L, Arnold DL, Bar-Or A, Comi G, de Seze J, Giovannoni G, Hartung HP, Hemmer B, et al: Ocrelizumab versus placebo in primary progressive multiple sclerosis. N Engl J Med. 376:209–220. 2017. View Article : Google Scholar

Lublin F, Miller DH, Freedman MS, Cree BAC, Wolinsky JS, Weiner H, Lubetzki C, Hartung HP, Montalban X, Uitdehaag BMJ, et al: Oral fingolimod in primary progressive multiple sclerosis (INFORMS): A phase 3, randomised, double-blind, placebo-controlled trial. Lancet. 387:1075–1084. 2016. View Article : Google Scholar : PubMed/NCBI

Waxman SG: Axonal conduction and injury in multiple sclerosis: The role of sodium channels. Nat Rev Neurosci. 7:932–941. 2006. View Article : Google Scholar : PubMed/NCBI

Picone P and Nuzzo D: Promising treatment for multiple sclerosis: Mitochondrial transplantation. Int J Mol Sci. 23:22452022. View Article : Google Scholar : PubMed/NCBI

Moos WH, Faller DV, Glavas IP, Kanara I, Kodukula K, Pernokas J, Pernokas M, Pinkert CA, Powers WR, Sampani K, et al: Epilepsy: Mitochondrial connections to the 'Sacred' disease. Mitochondrion. 72:84–101. 2023. View Article : Google Scholar : PubMed/NCBI

Silvestro S, Mammana S, Cavalli E, Bramanti P and Mazzon E: Use of cannabidiol in the treatment of epilepsy: Efficacy and security in clinical trials. Molecules. 24:14592019. View Article : Google Scholar : PubMed/NCBI

Ramirez A, Old W, Selwood DL and Liu X: Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles. Eur J Cell Biol. 101:1511852022. View Article : Google Scholar :

Bhunia S, Kolishetti N, Arias AY, Vashist A and Nair M: Cannabidiol for neurodegenerative disorders: A comprehensive review. Front Pharmacol. 13:9897172022. View Article : Google Scholar : PubMed/NCBI

Britch SC, Babalonis S and Walsh SL: Cannabidiol: Pharmacology and therapeutic targets. Psychopharmacology (Berl). 238:9–28. 2021. View Article : Google Scholar

Aledo-Serrano A, Hariramani R, Gonzalez-Martinez A, Álvarez-Troncoso J, Toledano R, Bayat A, Garcia-Morales I, Becerra JL, Villegas-Martínez I, Beltran-Corbellini A and Gil-Nagel A: Anakinra and tocilizumab in the chronic phase of febrile infection-related epilepsy syndrome (FIRES): Effectiveness and safety from a case-series. Seizure. 100:51–55. 2022. View Article : Google Scholar : PubMed/NCBI

Stienen MN, Haghikia A, Dambach H, Thöne J, Wiemann M, Gold R, Chan A, Dermietzel R, Faustmann PM, Hinkerohe D and Prochnow N: Anti-inflammatory effects of the anticonvulsant drug levetiracetam on electrophysiological properties of astroglia are mediated via TGFβ1 regulation. Br J Pharmacol. 162:491–507. 2011. View Article : Google Scholar :

Stockburger C, Miano D, Baeumlisberger M, Pallas T, Arrey TN, Karas M, Friedland K and Müller WE: A mitochondrial role of sv2a protein in aging and Alzheimer's disease: Studies with levetiracetam. J Alzheimers Dis. 50:201–215. 2016. View Article : Google Scholar

Yang N, Guan QW, Chen FH, Xia QX, Yin XX, Zhou HH and Mao XY: Antioxidants targeting mitochondrial oxidative stress: Promising neuroprotectants for epilepsy. Oxid Med Cell Longev. 2020:66871852020. View Article : Google Scholar : PubMed/NCBI

Fields M, Marcuzzi A, Gonelli A, Celeghini C, Maximova N and Rimondi E: Mitochondria-Targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: Perspectives and limitations. Int J Mol Sci. 24:37392023. View Article : Google Scholar : PubMed/NCBI

Huenchuguala S and Segura-Aguilar J: Single-neuron neurodegeneration as a degenerative model for Parkinson's disease. Neural Regen Res. 19:529–535. 2024. View Article : Google Scholar

Leitao-Rocha A, Guedes-Dias P, Pinho BR and Oliveira JM: Trends in mitochondrial therapeutics for neurological disease. Curr Med Chem. 22:2458–2467. 2015. View Article : Google Scholar : PubMed/NCBI

Yoshinaga N and Numata K: Rational designs at the forefront of mitochondria-targeted gene delivery: Recent progress and future perspectives. ACS Biomater Sci Eng. 8:348–359. 2022. View Article : Google Scholar : PubMed/NCBI

Silva-Pinheiro P and Minczuk M: The potential of mitochondrial genome engineering. Nat Rev Genet. 23:199–214. 2022. View Article : Google Scholar