Open Access

Cell death‑related molecules and targets in the progression of urolithiasis (Review)

  • Authors:
    • Liping Wu
    • Xiaoyan Xue
    • Chengwu He
    • Yongchang Lai
    • Lingfei Tong
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  • Published online on: April 22, 2024     https://doi.org/10.3892/ijmm.2024.5376
  • Article Number: 52
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Urolithiasis is a high‑incidence disease caused by calcium oxalate (mainly), uric acid, calcium phosphate, struvite, apatite, cystine and other stones. The development of kidney stones is closely related to renal tubule cell damage and crystal adhesion and aggregation. Cell death, comprising the core steps of cell damage, can be classified into various types (i.e., apoptosis, ferroptosis, necroptosis and pyroptosis). Different crystal types, concentrations, morphologies and sizes cause tubular cell damage via the regulation of different forms of cell death. Oxidative stress caused by high oxalate or crystal concentrations is considered to be a precursor to a variety of types of cell death. In addition, complex crosstalk exists among numerous signaling pathways and their key molecules in various types of cell death. Urolithiasis is considered a metabolic disorder, and tricarboxylic acid cycle‑related molecules, such as citrate and succinate, are closely related to cell death and the inhibition of stone development. However, a literature review of the associations between kidney stone development, metabolism and various types of cell death is currently lacking, at least to the best of our knowledge. Thus, the present review summarizes the major advances in the understanding of regulated cell death and urolithiasis progression.
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June-2024
Volume 53 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Wu L, Xue X, He C, Lai Y and Tong L: Cell death‑related molecules and targets in the progression of urolithiasis (Review). Int J Mol Med 53: 52, 2024.
APA
Wu, L., Xue, X., He, C., Lai, Y., & Tong, L. (2024). Cell death‑related molecules and targets in the progression of urolithiasis (Review). International Journal of Molecular Medicine, 53, 52. https://doi.org/10.3892/ijmm.2024.5376
MLA
Wu, L., Xue, X., He, C., Lai, Y., Tong, L."Cell death‑related molecules and targets in the progression of urolithiasis (Review)". International Journal of Molecular Medicine 53.6 (2024): 52.
Chicago
Wu, L., Xue, X., He, C., Lai, Y., Tong, L."Cell death‑related molecules and targets in the progression of urolithiasis (Review)". International Journal of Molecular Medicine 53, no. 6 (2024): 52. https://doi.org/10.3892/ijmm.2024.5376