Open Access

TMEM16 proteins: Ca2+‑activated chloride channels and phospholipid scramblases as potential drug targets (Review)

  • Authors:
    • Zeqi Huang
    • Zoya Iqbal
    • Zhe Zhao
    • Xiaoqiang Chen
    • Ayesha Mahmmod
    • Jianquan Liu
    • Wencui Li
    • Zhiqin Deng
  • View Affiliations

  • Published online on: July 29, 2024     https://doi.org/10.3892/ijmm.2024.5405
  • Article Number: 81
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

TMEM16 proteins, which function as Ca2+‑activated Cl channels are involved in regulating a wide variety of cellular pathways and functions. The modulators of Cl channels can be used for the molecule‑based treatment of respiratory diseases, cystic fibrosis, tumors, cancer, osteoporosis and coronavirus disease 2019. The TMEM16 proteins link Ca2+ signaling, cellular electrical activity and lipid transport. Thus, deciphering these complex regulatory mechanisms may enable a more comprehensive understanding of the physiological functions of the TMEM16 proteins and assist in ascertaining the applicability of these proteins as potential pharmacological targets for the treatment of a range of diseases. The present review examined the structures, functions and characteristics of the different types of TMEM16 proteins, their association with the pathogenesis of various diseases and the applicability of TMEM16 modulator‑based treatment methods.
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October-2024
Volume 54 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Huang Z, Iqbal Z, Zhao Z, Chen X, Mahmmod A, Liu J, Li W and Deng Z: TMEM16 proteins: Ca<sup>2+</sup>‑activated chloride channels and phospholipid scramblases as potential drug targets (Review). Int J Mol Med 54: 81, 2024.
APA
Huang, Z., Iqbal, Z., Zhao, Z., Chen, X., Mahmmod, A., Liu, J. ... Deng, Z. (2024). TMEM16 proteins: Ca<sup>2+</sup>‑activated chloride channels and phospholipid scramblases as potential drug targets (Review). International Journal of Molecular Medicine, 54, 81. https://doi.org/10.3892/ijmm.2024.5405
MLA
Huang, Z., Iqbal, Z., Zhao, Z., Chen, X., Mahmmod, A., Liu, J., Li, W., Deng, Z."TMEM16 proteins: Ca<sup>2+</sup>‑activated chloride channels and phospholipid scramblases as potential drug targets (Review)". International Journal of Molecular Medicine 54.4 (2024): 81.
Chicago
Huang, Z., Iqbal, Z., Zhao, Z., Chen, X., Mahmmod, A., Liu, J., Li, W., Deng, Z."TMEM16 proteins: Ca<sup>2+</sup>‑activated chloride channels and phospholipid scramblases as potential drug targets (Review)". International Journal of Molecular Medicine 54, no. 4 (2024): 81. https://doi.org/10.3892/ijmm.2024.5405