Open Access

Unveiling the multifaceted role of adropin in various diseases (Review)

  • Authors:
    • Ling Chen
    • Jianrao Lu
    • Jing Hu
    • Xuezhong Gong
  • View Affiliations

  • Published online on: August 13, 2024     https://doi.org/10.3892/ijmm.2024.5414
  • Article Number: 90
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adropin is a secreted peptide encoded by the energy homeostasis‑associated gene, which also functions as a membrane‑bound protein facilitating intercellular communication. This peptide has been detected in various tissues and body fluids, including the brain, liver, kidney, heart, pancreas, small intestine, endothelial cells and colostrum. Notably, the amino acid sequences of adropin are identical in humans, mice and rats. Previous studies have demonstrated that adropin levels fluctuate under different physiological and pathological conditions. Adropin plays a role in regulating carbohydrate metabolism, lipid metabolism and intercellular molecular signaling pathways, implicating its involvement in the progression of numerous diseases, such as acute myocardial infarction, lung injury, non‑alcoholic fatty liver disease/non‑alcoholic steatohepatitis, kidney disease, polycystic ovary syndrome, obesity, and diabetes, atherosclerosis, systemic sclerosis and cancer. Despite its significance, the precise role and mechanism of this protein remain inadequately understood and studied. To elucidate the function of adropin and its clinical research status, a systematic review of recent studies on adropin across various diseases was conducted. Additionally, several challenges and limitations associated with adropin research in both animal and clinical contexts were identified, aiming to offer valuable insights for future investigation.
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October-2024
Volume 54 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Chen L, Lu J, Hu J and Gong X: Unveiling the multifaceted role of adropin in various diseases (Review). Int J Mol Med 54: 90, 2024.
APA
Chen, L., Lu, J., Hu, J., & Gong, X. (2024). Unveiling the multifaceted role of adropin in various diseases (Review). International Journal of Molecular Medicine, 54, 90. https://doi.org/10.3892/ijmm.2024.5414
MLA
Chen, L., Lu, J., Hu, J., Gong, X."Unveiling the multifaceted role of adropin in various diseases (Review)". International Journal of Molecular Medicine 54.4 (2024): 90.
Chicago
Chen, L., Lu, J., Hu, J., Gong, X."Unveiling the multifaceted role of adropin in various diseases (Review)". International Journal of Molecular Medicine 54, no. 4 (2024): 90. https://doi.org/10.3892/ijmm.2024.5414