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Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer.

  • Authors:
    • H Sato
    • K Hiyama
    • S Ishioka
    • H Maeda
    • M Yamakido

  • View Affiliations

  • Published online on: July 1, 1999     https://doi.org/10.3892/ijo.15.1.81
  • Pages: 81-89
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Abstract

The FHIT gene is considered to be a tumor suppressor gene, its role and inactivation mechanism remain unclear. We analyzed FHIT gene aberrations in 64 lung cancer tissues and found that the appearance of the aberrant FHIT transcripts depends on the condition of RT-PCR and high telomerase activity, shortened telomere length, and advanced pathological stage were likely associated with the prevalence of aberrant FHIT transcripts, but not with allelic loss of the FHIT gene. These observations would indicate that an additional unknown gene may exist, which is more responsible for the allelic loss around the FHIT gene locus.

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Journal Cover

Jul 1999
Volume 15 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Sato H, Hiyama K, Ishioka S, Maeda H and Yamakido M: Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer.. Int J Oncol 15: 81-89, 1999.
APA
Sato, H., Hiyama, K., Ishioka, S., Maeda, H., & Yamakido, M. (1999). Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer.. International Journal of Oncology, 15, 81-89. https://doi.org/10.3892/ijo.15.1.81
MLA
Sato, H., Hiyama, K., Ishioka, S., Maeda, H., Yamakido, M."Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer.". International Journal of Oncology 15.1 (1999): 81-89.
Chicago
Sato, H., Hiyama, K., Ishioka, S., Maeda, H., Yamakido, M."Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer.". International Journal of Oncology 15, no. 1 (1999): 81-89. https://doi.org/10.3892/ijo.15.1.81