A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)

An,Jindan; Zhu,Xiaodong; Wang,Hongwei; Jin,Xiudong

doi:10.3892/ijo.2013.2047

A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)

Authors:
- Jindan An
- Xiaodong Zhu
- Hongwei Wang
- Xiudong Jin
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Affiliations: Key Laboratory of Cancer Prevention and Treatment of Heilongjiang Province, Mudanjiang Medical University, Mudanjiang, P.R. China, Department of Pathology, Mudanjiang Medical University, Mudanjiang, P.R. China
Published online on: August 1, 2013 https://doi.org/10.3892/ijo.2013.2047
Pages: 995-1001

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Abstract

Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA 3' UTRs. In this sense, different isoforms of an mRNA may be differentially regulated by microRNAs, sometimes resulting in cellular proliferation and this mechanism is being speculated on as a potential cause for cancer development.

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