Effects of D-allose in combination with docetaxel in human head and neck cancer cells

  • Authors:
    • Kanako Indo
    • Hiroshi Hoshikawa
    • Kazuyo Kamitori
    • Fuminori Yamaguchi
    • Terusige Mori
    • Masaaki Tokuda
    • Nozomu Mori
  • View Affiliations

  • Published online on: August 8, 2014     https://doi.org/10.3892/ijo.2014.2590
  • Pages: 2044-2050
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Abstract

In this study we investigated the combined effects of docetaxel and d-allose in HSC3 human oral carcinoma cells. The dose enhancement ratios at the 25% survival level were 1.3 and 1.71 for combined treatment with 10 or 25 mM D-allose, respectively. Apoptosis was significantly increased by addition of D-allose. Additionally, a synchronous increase in the G2/M-phase population was observed after docetaxel plus D-allose treatment. In vivo experiments revealed that docetaxel plus D-allose was more effective than either agent alone. Thus, D-allose enhanced the anticancer effects of docetaxel, and combined treatment may be useful to achieve clinical efficacy with reduced toxicity.
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November-2014
Volume 45 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Indo K, Hoshikawa H, Kamitori K, Yamaguchi F, Mori T, Tokuda M and Mori N: Effects of D-allose in combination with docetaxel in human head and neck cancer cells. Int J Oncol 45: 2044-2050, 2014.
APA
Indo, K., Hoshikawa, H., Kamitori, K., Yamaguchi, F., Mori, T., Tokuda, M., & Mori, N. (2014). Effects of D-allose in combination with docetaxel in human head and neck cancer cells. International Journal of Oncology, 45, 2044-2050. https://doi.org/10.3892/ijo.2014.2590
MLA
Indo, K., Hoshikawa, H., Kamitori, K., Yamaguchi, F., Mori, T., Tokuda, M., Mori, N."Effects of D-allose in combination with docetaxel in human head and neck cancer cells". International Journal of Oncology 45.5 (2014): 2044-2050.
Chicago
Indo, K., Hoshikawa, H., Kamitori, K., Yamaguchi, F., Mori, T., Tokuda, M., Mori, N."Effects of D-allose in combination with docetaxel in human head and neck cancer cells". International Journal of Oncology 45, no. 5 (2014): 2044-2050. https://doi.org/10.3892/ijo.2014.2590