Long non‑coding RNAs drive metastatic progression in melanoma (Review)

  • Authors:
    • Pouria Akhbari
    • Adrian Whitehouse
    • James R. Boyne
  • View Affiliations

  • Published online on: October 1, 2014     https://doi.org/10.3892/ijo.2014.2691
  • Pages: 2181-2186
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Metastatic melanoma is the leading cause of skin‑cancer related deaths and while in recent years some progress has been made with targeted therapies, there remains an urgent unmet need for novel therapeutic treatments and reliable diagnostic, prognostic and predictive biomarkers. The emergence of next generation sequencing (NGS) has seen a growing appreciation for the role played by non‑coding genomic transcripts in regulating gene expression and by extension impacting on disease progression. The long non‑coding RNAs (lncRNAs) represent the most enigmatic of these new regulatory molecules. Our understanding of how lncRNAs regulate biological functions and their importance to disease aetiology, while still limited, is rapidly improving, in particular with regards to their role in cancer. Herein we review the identification of several lncRNAs shown to impact on melanoma disease progression and discuss how these molecules are operating at the molecular level.
View Figures
View References

Related Articles

Journal Cover

December-2014
Volume 45 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Akhbari P, Whitehouse A and Boyne JR: Long non‑coding RNAs drive metastatic progression in melanoma (Review). Int J Oncol 45: 2181-2186, 2014.
APA
Akhbari, P., Whitehouse, A., & Boyne, J.R. (2014). Long non‑coding RNAs drive metastatic progression in melanoma (Review). International Journal of Oncology, 45, 2181-2186. https://doi.org/10.3892/ijo.2014.2691
MLA
Akhbari, P., Whitehouse, A., Boyne, J. R."Long non‑coding RNAs drive metastatic progression in melanoma (Review)". International Journal of Oncology 45.6 (2014): 2181-2186.
Chicago
Akhbari, P., Whitehouse, A., Boyne, J. R."Long non‑coding RNAs drive metastatic progression in melanoma (Review)". International Journal of Oncology 45, no. 6 (2014): 2181-2186. https://doi.org/10.3892/ijo.2014.2691