Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells

  • Authors:
    • Shimeng Zhang
    • Fei Liu
    • Xinru Mao
    • Jinlan Huang
    • Junyao Yang
    • Xiaomao Yin
    • Lijuan Wu
    • Lei Zheng
    • Qian Wang
  • View Affiliations

  • Published online on: September 14, 2015     https://doi.org/10.3892/ijo.2015.3162
  • Pages: 1759-1766
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Abstract

MicroRNAs (miRNAs) have been reported to be involved in multiple biological pathways that can influence tumor progression and metastasis. High-risk human papillomavirus (HR-HPVs) is aetiologically correlated to cervical cancer. Recently, miRNAs were reported to be regulated by virus and play pivotal roles in HPV-related tumor progression. However, the underlying mechanism remains poorly understood. In the present study, we report that HPV16 E7 upregulated miR-27b to promote proliferation and invasion in cervical cancer. The results showed that PPARγ, as a target of miR-27b, played a significant role in suppressing cervical cancer progression by downregulating the sodium-hydrogen exchanger isoform 1 (NHE1). It was also shown that the inhibition of miR-27b diminished the ability of HPV16 E7 to suppress PPARγ or activate NHE1 expression. In addition, we observed high expression of miR-27b and NHE1, but low expression of PPARγ in HPV16-positive cervical cancer tissues. In summary, the present study revealed that miR-27b is upregulated by HPV16 E7 to inhibit PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells.
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November-2015
Volume 47 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Zhang S, Liu F, Mao X, Huang J, Yang J, Yin X, Wu L, Zheng L and Wang Q: Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells. Int J Oncol 47: 1759-1766, 2015.
APA
Zhang, S., Liu, F., Mao, X., Huang, J., Yang, J., Yin, X. ... Wang, Q. (2015). Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells. International Journal of Oncology, 47, 1759-1766. https://doi.org/10.3892/ijo.2015.3162
MLA
Zhang, S., Liu, F., Mao, X., Huang, J., Yang, J., Yin, X., Wu, L., Zheng, L., Wang, Q."Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells". International Journal of Oncology 47.5 (2015): 1759-1766.
Chicago
Zhang, S., Liu, F., Mao, X., Huang, J., Yang, J., Yin, X., Wu, L., Zheng, L., Wang, Q."Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells". International Journal of Oncology 47, no. 5 (2015): 1759-1766. https://doi.org/10.3892/ijo.2015.3162