IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)

  • Authors:
    • Xinxin Long
    • Yingnan Ye
    • Lijie Zhang
    • Pengpeng Liu
    • Wenwen Yu
    • Feng Wei
    • Xiubao Ren
    • Jinpu Yu
  • View Affiliations

  • Published online on: November 6, 2015     https://doi.org/10.3892/ijo.2015.3234
  • Pages: 5-12
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Abstract

The epithelial-mesenchymal transition (EMT) is a process through which epithelial cells trans-differentiate and acquire an aggressive mesenchymal phenotype. In tumor cells, EMT is a vital step of tumor progression and metastasis. Amid the increasing interest in tumor EMT, only a few studies focused on the soluble mediators secreted by tumor cells passing through this phenotypic switch. In this review, we focus on the essential role of interleukin-8 (IL-8) signaling for the acquisition and maintenance of tumor EMT via direct and indirect mechanisms. Besides the autocrine loop between IL-8 and tumor cells that have gone through EMT, IL-8 could potentiate adjacent epithelial tumor cells into a mesenchymal phenotype via a paracrine mode. Moreover, understanding the role of IL-8 in EMT will provide insight into the pathogenesis of tumor progression and may facilitate the development of an effective strategy for the prevention and treatment of metastatic cancer.
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January-2016
Volume 48 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Long X, Ye Y, Zhang L, Liu P, Yu W, Wei F, Ren X and Yu J: IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review). Int J Oncol 48: 5-12, 2016.
APA
Long, X., Ye, Y., Zhang, L., Liu, P., Yu, W., Wei, F. ... Yu, J. (2016). IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review). International Journal of Oncology, 48, 5-12. https://doi.org/10.3892/ijo.2015.3234
MLA
Long, X., Ye, Y., Zhang, L., Liu, P., Yu, W., Wei, F., Ren, X., Yu, J."IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)". International Journal of Oncology 48.1 (2016): 5-12.
Chicago
Long, X., Ye, Y., Zhang, L., Liu, P., Yu, W., Wei, F., Ren, X., Yu, J."IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)". International Journal of Oncology 48, no. 1 (2016): 5-12. https://doi.org/10.3892/ijo.2015.3234