Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer

Retraction in: /10.3892/ijo.2024.5685

  • Authors:
    • Jinbao Sun
    • Haipeng Chu
    • Jianghai Ji
    • Gaoxiang Huo
    • Qinglei Song
    • Xue Zhang
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  • Published online on: June 30, 2016     https://doi.org/10.3892/ijo.2016.3589
  • Pages: 943-952
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Abstract

The long non-coding RNA HOX transcript antisense RNA (HOTAIR) has been found overexpressed in many human malignancies and involved in tumor progression and metastasis. However, little is known about the potential biological roles of HOTAIR in tumor escape. In the present study, the expression of HOTAIR was detected in 59 paired cervical cancer tissue samples by real-time PCR and then subjected to correlation analysis with clinical features. The effects of HOTAIR on cervical cancer cells as well as the expression of human leukocyte antigen (HLA)-G were studied by overexpression and RNA interference approaches. Insight into the mechanism of HOTAIR acting as competitive endogenous RNAs (ceRNAs) was gained from bioinformatic analysis and luciferase assays. HOTAIR expression was obviously increased in cervical cancer tissue. HOTAIR upregulation was associated with advanced pathological stage, histology, lymph node invasion and lymphatic metastasis, and also correlated with shorter overall survival of cervical cancer patients. Furthermore, HOTAIR overexpression promoted the proliferation, migration and invasion of cervical cancer cells, while HOTAIR knockdown inhibited cell invasion and cell viability, induced apoptosis and inhibited growth in vitro and in vivo. Moreover, HOTAIR modulated human leucocyte antigen-G (HLA-G) expression by competitively binding miR-148a. Our data suggest that HOTAIR plays an important oncogenic role in cervical cancer and might serve as a marker for cervical cancer prognosis and a potential target for therapeutic intervention.
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September-2016
Volume 49 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sun J, Chu H, Ji J, Huo G, Song Q and Zhang X: Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer Retraction in /10.3892/ijo.2024.5685. Int J Oncol 49: 943-952, 2016.
APA
Sun, J., Chu, H., Ji, J., Huo, G., Song, Q., & Zhang, X. (2016). Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer Retraction in /10.3892/ijo.2024.5685. International Journal of Oncology, 49, 943-952. https://doi.org/10.3892/ijo.2016.3589
MLA
Sun, J., Chu, H., Ji, J., Huo, G., Song, Q., Zhang, X."Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer Retraction in /10.3892/ijo.2024.5685". International Journal of Oncology 49.3 (2016): 943-952.
Chicago
Sun, J., Chu, H., Ji, J., Huo, G., Song, Q., Zhang, X."Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer Retraction in /10.3892/ijo.2024.5685". International Journal of Oncology 49, no. 3 (2016): 943-952. https://doi.org/10.3892/ijo.2016.3589