Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells

  • Authors:
    • Jin-Hee Lee
    • Sung-Su Kim
    • Hun Seok Lee
    • Sungyoul Hong
    • Nirmal Rajasekaran
    • Li-Hui Wang
    • Joon-Seok Choi
    • Young Kee Shin
  • View Affiliations

  • Published online on: December 6, 2016     https://doi.org/10.3892/ijo.2016.3793
  • Pages: 272-282
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Abstract

SMAD4 is a tumor suppressor that is frequently inactivated in many types of cancer. The role of abnormal expression of SMAD4 has been reported in developmental processes and the progression of various human cancers. The expression level of SMAD4 has been related to the survival rate in gastric cancer patients. However, the molecular mechanism underlying transcriptional regulation of SMAD4 remains largely unknown. In the present study, we characterized the promoter region of SMAD4 and identified myeloid zinc finger 1 (MZF1), as a putative transcription factor. MZF1 directly bound to a core region of the SMAD4 promoter and stimulated transcriptional activity. We also found that the expression of MZF1 influences the migration ability of gastric adenocarcinoma cells. Collectively, our results showed that MZF1 has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1-SMAD4 axis, a new therapeutic target in advanced human gastric cancer.
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January-2017
Volume 50 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lee J, Kim S, Lee HS, Hong S, Rajasekaran N, Wang L, Choi J and Shin YK: Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells. Int J Oncol 50: 272-282, 2017.
APA
Lee, J., Kim, S., Lee, H.S., Hong, S., Rajasekaran, N., Wang, L. ... Shin, Y.K. (2017). Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells. International Journal of Oncology, 50, 272-282. https://doi.org/10.3892/ijo.2016.3793
MLA
Lee, J., Kim, S., Lee, H. S., Hong, S., Rajasekaran, N., Wang, L., Choi, J., Shin, Y. K."Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells". International Journal of Oncology 50.1 (2017): 272-282.
Chicago
Lee, J., Kim, S., Lee, H. S., Hong, S., Rajasekaran, N., Wang, L., Choi, J., Shin, Y. K."Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells". International Journal of Oncology 50, no. 1 (2017): 272-282. https://doi.org/10.3892/ijo.2016.3793