Cancer stem cells and hypoxia-inducible factors (Review)
- Authors:
- Wei-Wei Tong
- Guang-Hui Tong
- Yong Liu
-
Affiliations: Department of Laboratory Medicine, Shengjing Affiliated Hospital, China Medical University, Shenyang, Liaoning 110004, P.R. China - Published online on: May 22, 2018 https://doi.org/10.3892/ijo.2018.4417
- Pages: 469-476
This article is mentioned in:
Abstract
Soni S and Padwad YS: HIF-1 in cancer therapy: Two decade long story of a transcription factor. Acta Oncol. 56:503–515. 2017. View Article : Google Scholar | |
Furth J and Kahn M: The transmission of leukemia of mice with a single cell. Am J Cancer. 31:276–282. 1937. | |
Southam CM and Brunschwig A: Quantitative studies of auto-transplantation of human cancer. Cancer. 14:971–978. 1961. View Article : Google Scholar | |
Hamburger AW and Salmon SE: Primary bioassay of human tumor stem cells. Science. 197:461–463. 1977. View Article : Google Scholar | |
Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA and Dick JE: A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 3. 67:645–648. 1994. View Article : Google Scholar | |
Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 3:730–737. 1997. View Article : Google Scholar | |
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA. 100:3983–3988. 2003. View Article : Google Scholar : PubMed/NCBI | |
Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD and Dirks PB: Identification of human brain tumour initiating cells. Nature. 432:396–401. 2004. View Article : Google Scholar : PubMed/NCBI | |
Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, Pilotti S, Pierotti MA and Daidone MG: Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 65:5506–5511. 2005. View Article : Google Scholar | |
Patrawala L, Calhoun T, Schneider-Broussard R, Li H, Bhatia B, Tang S, Reilly JG, Chandra D, Zhou J, Claypool K, et al: Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene. 25:1696–1708. 2006. View Article : Google Scholar | |
López J, Valdez-Morales FJ, Benítez-Bribiesca L, Cerbón M and Carrancá AG: Normal and cancer stem cells of the human female reproductive system. Reprod Biol Endocrinol. 11:532013. View Article : Google Scholar : | |
Takahashi K and Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 126:663–676. 2006. View Article : Google Scholar | |
Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, et al: Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell. 156:663–677. 2014. View Article : Google Scholar : PubMed/NCBI | |
Beck B and Blanpain C: Unravelling cancer stem cell potential. Nat Rev Cancer. 13:727–738. 2013. View Article : Google Scholar | |
Wang RA, Li ZS, Zhang HZ, Zheng PJ, Li QL, Shi JG, Yan QG, Ye J, Wang JB, Guo Y, et al: Invasive cancers are not necessarily from preformed in situ tumours - an alternative way of carcinogenesis from misplaced stem cells. J Cell Mol Med. 17:921–926. 2013. View Article : Google Scholar | |
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL and Wahl GM: Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 66:9339–9344. 2006. View Article : Google Scholar | |
Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer, and cancer stem cells. Nature. 414:105–111. 2001. View Article : Google Scholar : PubMed/NCBI | |
Cabrera MC, Hollingsworth RE and Hurt EM: Cancer stem cell plasticity and tumor hierarchy. World J Stem Cells. 7:27–36. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kuroda T, Yasuda S and Sato Y: Tumorigenicity studies for human pluripotent stem cell-derived products. Biol Pharm Bull. 36:189–192. 2013. View Article : Google Scholar : PubMed/NCBI | |
Adorno-Cruz V, Kibria G, Liu X, Doherty M, Junk DJ, Guan D, Hubert C, Venere M, Mulkearns-Hubert E, Sinyuk M, et al: Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Res. 75:924–929. 2015. View Article : Google Scholar : | |
O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 445:106–110. 2007. View Article : Google Scholar | |
Hope KJ, Jin L and Dick JE: Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol. 5:738–743. 2004. View Article : Google Scholar : PubMed/NCBI | |
Xia P, Gou WF, Zhao S and Zheng HC: Crizotinib may be used in Lewis lung carcinoma: A novel use for crizotinib. Oncol Rep. 30:139–148. 2013. View Article : Google Scholar : PubMed/NCBI | |
Vescovi AL, Galli R and Reynolds BA: Brain tumour stem cells. Nat Rev Cancer. 6:425–436. 2006. View Article : Google Scholar : PubMed/NCBI | |
Vargo-Gogola T and Rosen JM: Modelling breast cancer: One size does not fit all. Nat Rev Cancer. 7:659–672. 2007. View Article : Google Scholar : PubMed/NCBI | |
Tsai RY: Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too? Cell Mol Life Sci. 73:1803–1823. 2016. View Article : Google Scholar : | |
Huntly BJ and Gilliland DG: Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer. 5:311–321. 2005. View Article : Google Scholar : PubMed/NCBI | |
Daynac M and Petritsch CK: Regulation of asymmetric cell division in mammalian neural stem and cancer precursor cells. Results Probl Cell Differ. 61:375–399. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Bu P and Shen X: Asymmetric division: An antitumor player? Mol Cell Oncol. 3:e11642792016. View Article : Google Scholar : PubMed/NCBI | |
Wu L, Wang G, Liu S, Wei J, Zhang S, Li M, Zhou G and Wang L: Synthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agents. Sci Rep. 6:359182016. View Article : Google Scholar | |
Ait-Oudhia S and Mager DE: Array of translational systems pharmacodynamic models of anti-cancer drugs. J Pharmacokinet Pharmacodyn. 43:549–565. 2016. View Article : Google Scholar : PubMed/NCBI | |
O'Connor R, Clynes M, Dowling P, O'Donovan N and O'Driscoll L: Drug resistance in cancer - searching for mechanisms, markers and therapeutic agents. Expert Opin Drug Metab Toxicol. 3:805–817. 2007. View Article : Google Scholar : PubMed/NCBI | |
Yu Z, Pestell TG, Lisanti MP and Pestell RG: Cancer stem cells. Int J Biochem Cell Biol. 44:2144–2151. 2012. View Article : Google Scholar : PubMed/NCBI | |
Gottesman MM, Fojo T and Bates SE: Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer. 2:48–58. 2002. View Article : Google Scholar : PubMed/NCBI | |
Ramachandra M, Ambudkar SV, Chen D, Hrycyna CA, Dey S, Gottesman MM and Pastan I: Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state. Biochemistry. 37:5010–5019. 1998. View Article : Google Scholar : PubMed/NCBI | |
Dean M, Hamon Y and Chimini G: The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res. 42:1007–1017. 2001.PubMed/NCBI | |
Kort A, van Hoppe S, Sparidans RW, Wagenaar E, Beijnen JH and Schinkel AH: Brain accumulation of ponatinib and its active metabolite, N-desmethyl ponatinib, is limited by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2). Mol Pharm. 14:3258–3268. 2017. View Article : Google Scholar : PubMed/NCBI | |
Eckford PD and Sharom FJ: ABC efflux pump-based resistance to chemotherapy drugs. Chem Rev. 109:2989–3011. 2009. View Article : Google Scholar : PubMed/NCBI | |
Trock BJ, Leonessa F and Clarke R: Multidrug resistance in breast cancer: A meta-analysis of MDR1/gp170 expression and its possible functional significance. J Natl Cancer Inst. 89:917–931. 1997. View Article : Google Scholar : PubMed/NCBI | |
Zhou DC, Zittoun R and Marie JP: Expression of multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) genes in acute myeloid leukemia. Leukemia. 9:1661–1666. 1995.PubMed/NCBI | |
Grogan TM, Spier CM, Salmon SE, Matzner M, Rybski J, Weinstein RS, Scheper RJ and Dalton WS: P-glycoprotein expression in human plasma cell myeloma: Correlation with prior chemotherapy. Blood. 81:490–495. 1993.PubMed/NCBI | |
Chan HS, Grogan TM, Haddad G, DeBoer G and Ling V: P-glycoprotein expression: Critical determinant in the response to osteosarcoma chemotherapy. J Natl Cancer Inst. 89:1706–1715. 1997. View Article : Google Scholar : PubMed/NCBI | |
Gillet JP and Gottesman MM: Mechanisms of multidrug resistance in cancer. Methods Mol Biol. 596:47–76. 2010. View Article : Google Scholar | |
Leslie EM, Deeley RG and Cole SP: Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol. 204:216–237. 2005. View Article : Google Scholar : PubMed/NCBI | |
Rohwer N and Cramer T: Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat. 14:191–201. 2011. View Article : Google Scholar : PubMed/NCBI | |
da Costa KM, Valente RC, Salustiano EJ, Gentile LB, Freire-de-Lima L, Mendonça-Previato L and Previato JO: Functional Characterization of ABCC proteins from trypanosoma cruzi and their involvement with thiol transport. Front Microbiol. 9:2052018. View Article : Google Scholar : | |
Yin JY, Han LF, Huang Q, Xu XJ, Zhou HH and Liu ZQ: ABCC1 polymorphism Arg723Gln (2168G> A) is associated with lung cancer susceptibility in a Chinese population. Clin Exp Pharmacol Physiol. 38:632–637. 2011. View Article : Google Scholar : PubMed/NCBI | |
Arumugam P and Song JM: Quantitative evaluation of ABC transporter-mediated drug resistance based on the determination of the anticancer activity of camptothecin against breast cancer stem cells using TIRF. Integr Biol. 8:704–711. 2016. View Article : Google Scholar | |
Liu C, Li Z, Bi L, Li K, Zhou B, Xu C, Huang J and Xu K: NOTCH1 signaling promotes chemoresistance via regulating ABCC1 expression in prostate cancer stem cells. Mol Cell Biochem. 393:265–270. 2014. View Article : Google Scholar : PubMed/NCBI | |
Johnson ZL and Chen J: ATP binding enables substrate release from multidrug resistance protein 1. Cell. 172:81–89.e10. 2018. View Article : Google Scholar : PubMed/NCBI | |
Castilho L and Reid ME: A review of the JR blood group system. Immunohematology. 29:63–68. 2013.PubMed/NCBI | |
Fujita K and Ichida K: ABCG2 as a therapeutic target candidate for gout. Expert Opin Ther Targets. 22:123–129. 2018. View Article : Google Scholar | |
D'Ignazio L, Batie M and Rocha S: Hypoxia and inflammation in cancer, focus on HIF and NF-κB. Biomedicines. 5:E212017. View Article : Google Scholar | |
Zhang P, Yao Q, Lu L, Li Y, Chen PJ and Duan C: Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Reports. 6:1110–1121. 2014. View Article : Google Scholar : PubMed/NCBI | |
Wang GL, Jiang BH, Rue EA and Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 92:5510–5514. 1995. View Article : Google Scholar : PubMed/NCBI | |
Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H and Poellinger L: Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J. 17:6573–6586. 1998. View Article : Google Scholar : PubMed/NCBI | |
Dayan F, Roux D, Brahimi-Horn MC, Pouyssegur J and Mazure NM: The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha. Cancer Res. 66:3688–3698. 2006. View Article : Google Scholar : PubMed/NCBI | |
Jiang BH, Semenza GL, Bauer C and Marti HH: Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol. 271:C1172–C1180. 1996. View Article : Google Scholar : PubMed/NCBI | |
Hu CJ, Sataur A, Wang L, Chen H and Simon MC: The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 18:4528–4542. 2007. View Article : Google Scholar : PubMed/NCBI | |
Badowska-Kozakiewicz AM, Sobol M and Patera J: Expression of multidrug resistance protein P-glycoprotein in correlation with markers of hypoxia (HIF-1α, EPO, EPO-R) in invasive breast cancer with metastasis to lymph nodes. Arch Med Sci. 13:1303–1314. 2017. View Article : Google Scholar : PubMed/NCBI | |
Rodríguez ME, Catrinacio C, Ropolo A, Rivarola VA and Vaccaro MI: A novel HIF-1α/VMP1-autophagic pathway induces resistance to photodynamic therapy in colon cancer cells. Photochem Photobiol Sci. 16:1631–1642. 2017. View Article : Google Scholar | |
Shao JS, Sun J, Wang S, Chung K, Du JT, Wang J, Qiu XS, Wang EH and Wu GP: HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells. Tumour Biol. 39:1010428317717137. 2017. View Article : Google Scholar | |
Zhang Q, Lou Y, Zhang J, Fu Q, Wei T, Sun X, Chen Q, Yang J, Bai X and Liang T: Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer. Mol Cancer. 16:1192017. View Article : Google Scholar | |
Raspaglio G, Petrillo M, Martinelli E, Li Puma DD, Mariani M, De Donato M, Filippetti F, Mozzetti S, Prislei S, Zannoni GF, et al: Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressiveness. Gene. 542:173–181. 2014. View Article : Google Scholar : PubMed/NCBI | |
Jun JC, Rathore A, Younas H, Gilkes D and Polotsky VY: Hypoxia-Inducible Factors and Cancer. Curr Sleep Med Rep. 3:1–10. 2017. View Article : Google Scholar : PubMed/NCBI | |
Vandyke K, Zeissig MN, Hewett DR, Martin SK, Mrozik KM, Cheong CM, Diamond P, To LB, Gronthos S, Peet DJ, et al: HIF-2α promotes dissemination of plasma cells in multiple myeloma by regulating CXCL12/CXCR4 and CCR1. Cancer Res. 77:5452–5463. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ma X, Zhang H, Xue X and Shah YM: Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J Biol Chem. 292:17046–17056. 2017. View Article : Google Scholar : PubMed/NCBI | |
Garziera M, Scarabel L and Toffoli G: Hypoxic modulation of HLA-G expression through the metabolic sensor HIF-1 in human cancer cells. J Immunol Res. 2017:45875202017. View Article : Google Scholar : PubMed/NCBI | |
Anam MT, Ishika A, Hossain MB and Jesmin: A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: Association with cancers. Biomark Res. 3:292015. View Article : Google Scholar : PubMed/NCBI | |
Frank B, Hoffmeister M, Klopp N, Illig T, Chang-Claude J and Brenner H: Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. Carcinogenesis. 31:1381–1386. 2010. View Article : Google Scholar : PubMed/NCBI | |
Guo X, Li D, Chen Y, An J, Wang K, Xu Z, Chen Z and Xing J: SNP rs2057482 in HIF1A gene predicts clinical outcome of aggressive hepatocellular carcinoma patients after surgery. Sci Rep. 5:118462015. View Article : Google Scholar : PubMed/NCBI | |
Han SS, Yeager M, Moore LE, Wei MH, Pfeiffer R, Toure O, Purdue MP, Johansson M, Scelo G, Chung CC, et al: The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma. Hum Mol Genet. 21:1190–1200. 2012. View Article : Google Scholar : | |
Yamamoto Y, Kiyohara C, Ogata-Suetsugu S, Hamada N and Nakanishi Y: Association between genetic polymorphisms involved in the hypoxia-inducible factor pathway and lung cancer risk: A case-control study in Japan. Asia Pac J Clin Oncol. 13:234–242. 2017. View Article : Google Scholar | |
Haja Mohideen AM, Hyde A, Squires J, Wang J, Dicks E, Younghusband B, Parfrey P, Green R and Savas S: Examining the polymorphisms in the hypoxia pathway genes in relation to outcome in colorectal cancer. PLoS One. 9:e1135132014. View Article : Google Scholar : PubMed/NCBI | |
Autour A, Jeng S C Y, Cawte A D, Abdolahzadeh A, Galli A, Panchapakesan SSS, Rueda D, Ryckelynck M and Unrau PJ: Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells. Nat Commun. 9:6562018. View Article : Google Scholar : PubMed/NCBI | |
Camps C, Saini HK, Mole DR, Choudhry H, Reczko M, Guerra-Assunção JA, Tian YM, Buffa FM, Harris AL, Hatzigeorgiou AG, et al: Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia. Mol Cancer. 13:282014. View Article : Google Scholar : PubMed/NCBI | |
Ho JJ, Metcalf JL, Yan MS, Turgeon PJ, Wang JJ, Chalsev M, Petruzziello-Pellegrini TN, Tsui AK, He JZ, Dhamko H, et al: Functional importance of Dicer protein in the adaptive cellular response to hypoxia. J Biol Chem. 287:29003–29020. 2012. View Article : Google Scholar : PubMed/NCBI | |
van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, et al: Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun. 5:52032014. View Article : Google Scholar : PubMed/NCBI | |
Montoya MM, Maul J, Singh PB, Pua HH, Dahlström F, Wu N, Huang X, Ansel KM and Baumjohann D: A distinct inhibitory function for miR-18a in Th17 cell differentiation. J Immunol. 199:559–569. 2017. View Article : Google Scholar : PubMed/NCBI | |
Li JY, Zhang Y, Zhang WH, Jia S, Kang Y and Zhu XY: Differential distribution of miR-20a and miR-20b may underly metastatic heterogeneity of breast cancers. Asian Pac J Cancer Prev. 13:1901–1906. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kunej T, Obsteter J, Pogacar Z, Horvat S and Calin GA: The decalog of long non-coding RNA involvement in cancer diagnosis and monitoring. Crit Rev Clin Lab Sci. 51:344–357. 2014. View Article : Google Scholar : PubMed/NCBI | |
Im JH and Muschel RJ: New evidence of lncRNA role in tumor progression and metastasis. Hepatobiliary Surg Nutr. 1:55–56. 2012.PubMed/NCBI | |
Schito L and Semenza GL: Hypoxia-inducible factors: Master regulators of cancer progression. Trends Cancer. 2:758–770. 2016. View Article : Google Scholar | |
Mohlin S, Wigerup C, Jögi A and Påhlman S: Hypoxia, pseudo-hypoxia and cellular differentiation. Exp Cell Res. 356:192–196. 2017. View Article : Google Scholar : PubMed/NCBI | |
Shi QY, Zhang SJ, Liu L, Chen QS, Yu LN, Zhang FJ and Yan M: Sevoflurane promotes the expansion of glioma stem cells through activation of hypoxia-inducible factors in vitro. Br J Anaesth. 114:825–830. 2015. View Article : Google Scholar | |
Lee G, Auffinger B, Guo D, Hasan T, Deheeger M, Tobias AL, Kim JY, Atashi F, Zhang L, Lesniak MS, et al: Dedifferentiation of glioma cells to glioma stem-like cells by therapeutic stress-induced HIF signaling in the recurrent GBM model. Mol Cancer Ther. 15:3064–3076. 2016. View Article : Google Scholar : PubMed/NCBI | |
Zhang S, Luo X, Wan F and Lei T: The roles of hypoxia-inducible factors in regulating neural stem cells migration to glioma stem cells and determinating their fates. Neurochem Res. 37:2659–2666. 2012. View Article : Google Scholar : PubMed/NCBI | |
Semenza GL: Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors. Clin Sci (Lond). 129:1037–1045. 2015. View Article : Google Scholar | |
Samanta D, Gilkes DM, Chaturvedi P, Xiang L and Semenza GL: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci USA. 111:E5429–E5438. 2014. View Article : Google Scholar : PubMed/NCBI | |
Deynoux M, Sunter N, Hérault O and Mazurier F: Hypoxia and hypoxia-inducible factors in leukemias. Front Oncol. 6:412016. View Article : Google Scholar : PubMed/NCBI | |
Heddleston JM, Wu Q, Rivera M, Minhas S, Lathia JD, Sloan AE, Iliopoulos O, Hjelmeland AB and Rich JN: Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. Cell Death Differ. 19:428–439. 2012. View Article : Google Scholar | |
Sun JC, He F, Yi W, Wan MH, Li R, Wei X, Wu R and Niu DL: High expression of HIF-2α and its anti-radiotherapy effect in lung cancer stem cells. Genet Mol Res. 14:18110–18120. 2015. View Article : Google Scholar | |
Dhatwalia SK, Kumar M and Dhawan DK: Role of EGCG in containing the progression of lung tumorigenesis - A multistage targeting approach. Nutr Cancer. 70:334–349. 2018. View Article : Google Scholar : PubMed/NCBI | |
Vadde R, Vemula S, Jinka R, Merchant N, Bramhachari PV and Nagaraju GP: Role of hypoxia-inducible factors (HIF) in the maintenance of stemness and malignancy of colorectal cancer. Crit Rev Oncol Hematol. 113:22–27. 2017. View Article : Google Scholar : PubMed/NCBI | |
Thomas S, Harding MA, Smith SC, Overdevest JB, Nitz MD, Frierson HF, Tomlins SA, Kristiansen G and Theodorescu D: CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Cancer Res. 72:5600–5612. 2012. View Article : Google Scholar : PubMed/NCBI | |
Bhagat M, Palanichamy JK, Ramalingam P, Mudassir M, Irshad K, Chosdol K, Sarkar C, Seth P, Goswami S, Sinha S, et al: HIF-2α mediates a marked increase in migration and stemness characteristics in a subset of glioma cells under hypoxia by activating an Oct-4/Sox-2-Mena (INV) axis. Int J Biochem Cell Biol. 74:60–71. 2016. View Article : Google Scholar : PubMed/NCBI | |
Johansson E, Grassi ES, Pantazopoulou V, Tong B, Lindgren D, Berg TJ, Pietras EJ, Axelson H and Pietras A: CD44 interacts with HIF-2α to modulate the hypoxic phenotype of perinecrotic and perivascular glioma cells. Cell Reports. 20:1641–1653. 2017. View Article : Google Scholar |