Open Access

Induction/reversal of drug resistance in gastric cancer by non-coding RNAs (Review)

  • Authors:
    • Chao Chen
    • Xiaohuan Tang
    • Yuanda Liu
    • Jiaming Zhu
    • Jingjing Liu
  • View Affiliations

  • Published online on: March 18, 2019     https://doi.org/10.3892/ijo.2019.4751
  • Pages: 1511-1524
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC) is one of the most prevalent and malignant types of cancer worldwide. In China, it is the second most common type of cancer and the malignancy with the highest incidence and mortality rate. Chemotherapy for GC is not always effective due to the development of drug resistance. Drug resistance, which is frequently observed in GC, undermines the success rate of chemotherapy and the survival of patients with GC. The dysregulation of non‑coding RNAs (ncRNAs), primarily microRNAs (miRNAs or miRs) and long non‑coding RNAs (lncRNAs), is involved in the development of GC drug resistance via numerous mechanisms. These mechanisms contribute to the involvement of a large and complex network of ncRNAs in drug resistance. In this review, we focus on and summarize the latest research on the specific mechanisms of action of miRNAs and lncRNAs that modulate drug resistance in GC. In addition, we discuss future prospects and clinical applications of ncRNAs as potential targeted therapies against the chemoresistance of GC.
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May-2019
Volume 54 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Chen C, Tang X, Liu Y, Zhu J and Liu J: Induction/reversal of drug resistance in gastric cancer by non-coding RNAs (Review). Int J Oncol 54: 1511-1524, 2019.
APA
Chen, C., Tang, X., Liu, Y., Zhu, J., & Liu, J. (2019). Induction/reversal of drug resistance in gastric cancer by non-coding RNAs (Review). International Journal of Oncology, 54, 1511-1524. https://doi.org/10.3892/ijo.2019.4751
MLA
Chen, C., Tang, X., Liu, Y., Zhu, J., Liu, J."Induction/reversal of drug resistance in gastric cancer by non-coding RNAs (Review)". International Journal of Oncology 54.5 (2019): 1511-1524.
Chicago
Chen, C., Tang, X., Liu, Y., Zhu, J., Liu, J."Induction/reversal of drug resistance in gastric cancer by non-coding RNAs (Review)". International Journal of Oncology 54, no. 5 (2019): 1511-1524. https://doi.org/10.3892/ijo.2019.4751