Open Access

Comprehensive identification and characterization of somatic copy number alterations in triple‑negative breast cancer

  • Authors:
    • Zaibing Li
    • Xiao Zhang
    • Chenxin Hou
    • Yuqing Zhou
    • Junli Chen
    • Haoyang Cai
    • Yifeng Ye
    • Jinping Liu
    • Ning Huang
  • View Affiliations

  • Published online on: December 23, 2019     https://doi.org/10.3892/ijo.2019.4950
  • Pages: 522-530
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Triple‑negative breast cancer (TNBC) accounts for ~15% of all breast cancer diagnoses each year. Patients with TNBC tend to have a higher risk for early relapse and a worse prognosis. TNBC is characterized by extensive somatic copy number alterations (CNAs). However, the DNA CNA profile of TNBC remains to be extensively investigated. The present study assessed the genomic profile of CNAs in 201 TNBC samples, aiming to identify recurrent CNAs that may drive the pathogenesis of TNBC. In total, 123 regions of significant amplification and deletion were detected using the Genomic Identification of Significant Targets in Cancer algorithm, and potential driver genes for TNBC were identified. A total of 31 samples exhibited signs of chromothripsis and revealed chromosome pulverization hotspot regions. The present study further determined 199 genomic locations that were significantly enriched for breakpoints, which indicated TNBC‑specific genomic instability regions. Unsupervised hierarchical clustering of tumors resulted in three main subgroups that exhibited distinct CNA profiles, which may reveal the heterogeneity of molecular mechanisms in TNBC subgroups. These results will extend the molecular understanding of TNBC and will facilitate the discovery of therapeutic and diagnostic target candidates.
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February-2020
Volume 56 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Li Z, Zhang X, Hou C, Zhou Y, Chen J, Cai H, Ye Y, Liu J and Huang N: Comprehensive identification and characterization of somatic copy number alterations in triple‑negative breast cancer. Int J Oncol 56: 522-530, 2020.
APA
Li, Z., Zhang, X., Hou, C., Zhou, Y., Chen, J., Cai, H. ... Huang, N. (2020). Comprehensive identification and characterization of somatic copy number alterations in triple‑negative breast cancer. International Journal of Oncology, 56, 522-530. https://doi.org/10.3892/ijo.2019.4950
MLA
Li, Z., Zhang, X., Hou, C., Zhou, Y., Chen, J., Cai, H., Ye, Y., Liu, J., Huang, N."Comprehensive identification and characterization of somatic copy number alterations in triple‑negative breast cancer". International Journal of Oncology 56.2 (2020): 522-530.
Chicago
Li, Z., Zhang, X., Hou, C., Zhou, Y., Chen, J., Cai, H., Ye, Y., Liu, J., Huang, N."Comprehensive identification and characterization of somatic copy number alterations in triple‑negative breast cancer". International Journal of Oncology 56, no. 2 (2020): 522-530. https://doi.org/10.3892/ijo.2019.4950