Biomarkers of tumor invasiveness in proteomics (Review)

Pouliquen,Daniel  L.; Boissard,Alice; Coqueret,Olivier; Guette,Catherine

doi:10.3892/ijo.2020.5075

Biomarkers of tumor invasiveness in proteomics (Review)

Authors:
- Daniel L. Pouliquen
- Alice Boissard
- Olivier Coqueret
- Catherine Guette
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Affiliations: CRCINA, Inserm, Université d'Angers, F‑44000 Nantes, France, Paul Papin ICO Cancer Center, CRCINA, Inserm, Université d'Angers, F‑44000 Nantes, France
Published online on: May 28, 2020 https://doi.org/10.3892/ijo.2020.5075
Pages: 409-432
Copyright: © Pouliquen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Over the past two decades, quantitative proteomics has emerged as an important tool for deciphering the complex molecular events involved in cancers. The number of references involving studies on the cancer metastatic process has doubled since 2010, while the last 5 years have seen the development of novel technologies combining deep proteome coverage capabilities with quantitative consistency and accuracy. To highlight key findings within this huge amount of information, the present review identified a list of tumor invasive biomarkers based on both the literature and data collected on a biocollection of experimental cell lines, tumor models of increasing invasiveness and tumor samples from patients with colorectal or breast cancer. Crossing these different data sources led to 76 proteins of interest out of 1,245 mentioned in the literature. Information on these proteins can potentially be translated into clinical prospects, since they represent potential targets for the development and evaluation of innovative therapies, alone or in combination. Herein, a systematical review of the biology of each of these proteins, including their specific subcellular/extracellular or multiple localizations is presented. Finally, as an important advantage of quantitative proteomics is the ability to provide data on all these molecules simultaneously in cell pellets, body fluids or paraffin‑embedded sections of tumors/invaded tissues, the significance of some of their interconnections is discussed.

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