Open Access

TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

  • Authors:
    • Tanveer Ahmad
    • Waseem Ashraf
    • Abdulkhaleg Ibrahim
    • Liliyana Zaayter
    • Christian D. Muller
    • Ali Hamiche
    • Yves Mély
    • Christian Bronner
    • Marc Mousli
  • View Affiliations

  • Published online on: September 23, 2021     https://doi.org/10.3892/ijo.2021.5269
  • Article Number: 89
  • Copyright: © Ahmad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tat interactive protein, 60 kDa (TIP60) is an important partner of ubiquitin‑like, containing PHD and RING finger domains 1 (UHRF1), ensuring various cellular processes through its acetyltransferase activity. TIP60 is believed to play a tumor suppressive role, partly explained by its downregulated expression in a number of cancers. The aim of the present study was to investigate the role and mechanisms of action of TIP60 in the regulation of UHRF1 expression. The results revealed that TIP60 overexpression downregulated the UHRF1 and DNA methyltransferase 1 (DNMT1) expression levels. TIP60 interfered with USP7‑UHRF1 association and induced the degradation of UHRF1 in an auto‑ubiquitination‑dependent manner. Moreover, TIP60 activated the p73‑mediated apoptotic pathway. Taken together, the data of the present study suggest that the tumor suppressor role of TIP60 is mediated by its regulation to UHRF1.
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November-2021
Volume 59 Issue 5

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Spandidos Publications style
Ahmad T, Ashraf W, Ibrahim A, Zaayter L, Muller CD, Hamiche A, Mély Y, Bronner C and Mousli M: TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex. Int J Oncol 59: 89, 2021.
APA
Ahmad, T., Ashraf, W., Ibrahim, A., Zaayter, L., Muller, C.D., Hamiche, A. ... Mousli, M. (2021). TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex. International Journal of Oncology, 59, 89. https://doi.org/10.3892/ijo.2021.5269
MLA
Ahmad, T., Ashraf, W., Ibrahim, A., Zaayter, L., Muller, C. D., Hamiche, A., Mély, Y., Bronner, C., Mousli, M."TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex". International Journal of Oncology 59.5 (2021): 89.
Chicago
Ahmad, T., Ashraf, W., Ibrahim, A., Zaayter, L., Muller, C. D., Hamiche, A., Mély, Y., Bronner, C., Mousli, M."TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex". International Journal of Oncology 59, no. 5 (2021): 89. https://doi.org/10.3892/ijo.2021.5269