Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer

  • Authors:
    • Bayarbat Tsevegjav
    • Atsushi Takano
    • Ming Zhu
    • Yoshihiro Yoshitake
    • Masanori Shinohara
    • Yataro Daigo
  • View Affiliations

  • Published online on: January 31, 2022     https://doi.org/10.3892/ijo.2022.5316
  • Article Number: 26
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Since oral cancer (OC) is highly malignant and the efficacy of standard treatments is limited, the development of new therapeutics is urgently awaited. To identify potential molecular targets for new OC diagnosis and therapies, we screened oncoantigens by gene expression profile and focused on Holliday junction recognition protein (HJURP), a mammalian centromere‑specific chaperone. HJURP was found to be highly expressed in the majority of OC cell lines and tissues as compared to normal oral epithelial cells. Tissue microarray analysis confirmed that HJURP was expressed in 103 (67.8%) of 152 OC tissue specimens, but expression in normal oral tissues was limited. Positive HJURP expression was significantly correlated with shorter overall survival (P=0.003). Depletion of HJURP by small‑interfering RNAs dramatically inhibited the growth of OC cells by inhibition of cell cycle progression and induced senescence of OC cells. In addition, inhibition of the interaction between HJURP and CENP‑A significantly suppressed the growth of OC cells. These results indicate that HJURP is a potential prognostic biomarker, and targeting HJURP and its molecular pathway presents a new strategy for the development of treatments against OC.
View Figures
View References

Related Articles

Journal Cover

March-2022
Volume 60 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tsevegjav B, Takano A, Zhu M, Yoshitake Y, Shinohara M and Daigo Y: Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer. Int J Oncol 60: 26, 2022.
APA
Tsevegjav, B., Takano, A., Zhu, M., Yoshitake, Y., Shinohara, M., & Daigo, Y. (2022). Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer. International Journal of Oncology, 60, 26. https://doi.org/10.3892/ijo.2022.5316
MLA
Tsevegjav, B., Takano, A., Zhu, M., Yoshitake, Y., Shinohara, M., Daigo, Y."Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer". International Journal of Oncology 60.3 (2022): 26.
Chicago
Tsevegjav, B., Takano, A., Zhu, M., Yoshitake, Y., Shinohara, M., Daigo, Y."Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer". International Journal of Oncology 60, no. 3 (2022): 26. https://doi.org/10.3892/ijo.2022.5316