Open Access

Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review)

  • Authors:
    • Xiuzhen Zhang
    • Tong Meng
    • Shuaishuai Cui
    • Dongwu Liu
    • Qiuxiang Pang
    • Ping Wang
  • View Affiliations

  • Published online on: May 25, 2022     https://doi.org/10.3892/ijo.2022.5374
  • Article Number: 84
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The interaction between a tumor and the tumor microenvironment (TME) plays a key role in tumorigenesis and tumor progression. Ubiquitination, a crucial post‑translational modification for regulating protein degradation and turnover, plays a role in regulating the crosstalk between a tumor and the TME. Thus, identifying the roles of ubiquitination in the process may assist researchers to investigate the mechanisms underlying tumorigenesis and tumor progression. In the present review article, new insights into the substrates for ubiquitination that are involved in the regulation of hypoxic environments, angiogenesis, chronic inflammation‑mediated tumor formation, and the function of cancer‑associated fibroblasts and infiltrating immune cells (tumor‑associated macrophages, T‑cells, myeloid‑derived suppressor cells, dendritic cells, and natural killer cells) are summarized. In addition, the potential targets of the ubiquitination proteasome system within the TME for cancer therapy and their therapeutic effects are reviewed and discussed.
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July-2022
Volume 61 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang X, Meng T, Cui S, Liu D, Pang Q and Wang P: Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review). Int J Oncol 61: 84, 2022.
APA
Zhang, X., Meng, T., Cui, S., Liu, D., Pang, Q., & Wang, P. (2022). Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review). International Journal of Oncology, 61, 84. https://doi.org/10.3892/ijo.2022.5374
MLA
Zhang, X., Meng, T., Cui, S., Liu, D., Pang, Q., Wang, P."Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review)". International Journal of Oncology 61.1 (2022): 84.
Chicago
Zhang, X., Meng, T., Cui, S., Liu, D., Pang, Q., Wang, P."Roles of ubiquitination in the crosstalk between tumors and the tumor microenvironment (Review)". International Journal of Oncology 61, no. 1 (2022): 84. https://doi.org/10.3892/ijo.2022.5374