Role of N<sup>6</sup>‑methyladenosine in the pathogenesis, diagnosis and treatment of pancreatic cancer (Review)

Ye,Tong; Wang,Jiaxin; Zhao,Haiying; Zhao,Guiping; Li,Peng

doi:10.3892/ijo.2022.5452

Role of N⁶‑methyladenosine in the pathogenesis, diagnosis and treatment of pancreatic cancer (Review)

Authors:
- Tong Ye
- Jiaxin Wang
- Haiying Zhao
- Guiping Zhao
- Peng Li
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Affiliations: Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China
Published online on: November 10, 2022 https://doi.org/10.3892/ijo.2022.5452
Article Number: 4
Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic cancer (PC) ranks as the seventh leading cause of cancer‑associated mortality, and is predicted to become the third leading cause of cancer‑associated mortality by the year 2025. Although advanced modalities of diagnosis and treatment have been continuously emerging, the mortality rate (466,003) approximated to that of the morbidity rate (495,773) in 2020. N⁶‑methyladenosine (m⁶A) has been shown to be methylated on the sixth N atom of adenine in RNA, which occurs co‑transcriptionally and serves to regulate gene expression post‑transcriptionally. The discovery of m⁶A has heralded a new era in the scientific investigation of PC. In the present review article, the classical conception of m⁶A and emerging hypotheses regarding its role are summarized, and the function of m⁶A in carcinogenesis and progression of PC is then discussed, followed by the potential roles of m⁶A in the diagnosis of PC and in therapeutic applications. However, this new era is only at the initial stages, and the extent to which m⁶A influences PC is still poorly understood. In view of this, the present review article also summarizes the developments at the frontier of the interaction between m⁶A and PC, and discusses strategies through which m⁶A may provide a promising avenue for anticancer therapy.

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