Open Access

MicroRNA in adenoid cystic carcinoma (Review)

  • Authors:
    • Yunshan Li
    • Feihan Gu
    • Yaodong He
    • Junwei Xiang
    • Xu Huang
    • Yuanyin Wang
    • Ran Chen
  • View Affiliations

  • Published online on: December 9, 2022     https://doi.org/10.3892/ijo.2022.5465
  • Article Number: 17
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adenoid cystic carcinoma (ACC) usually arises in the salivary glands, and is a rare tumor, accounting for 1% of all head and neck cancer cases. According to estimates, there are 3‑4.5 cases of ACC for every one million individuals. Numerous studies have reported the association between ACC and microRNAs (miRNAs/miRs). miRNAs are endogenous, non‑coding small RNAs, 19‑25 nt in length, that can regulate target gene expression at the post‑transcriptional level. The aberrant expression of miRNAs may be associated with the prognosis and treatment of patients, as well as with tumorigenesis and tumor development. miRNAs are becoming reliable biomarkers for disease detection due to their varied characteristics, and miRNA target‑based therapies are increasingly being used in clinical practice. The present review provides a brief introduction to ACC and the biogenesis of miRNAs. A summary of the miRNAs that have been validated by in vitro or in vivo studies is then presented, describing their role in ACC.
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January-2023
Volume 62 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Li Y, Gu F, He Y, Xiang J, Huang X, Wang Y and Chen R: MicroRNA in adenoid cystic carcinoma (Review). Int J Oncol 62: 17, 2023
APA
Li, Y., Gu, F., He, Y., Xiang, J., Huang, X., Wang, Y., & Chen, R. (2023). MicroRNA in adenoid cystic carcinoma (Review). International Journal of Oncology, 62, 17. https://doi.org/10.3892/ijo.2022.5465
MLA
Li, Y., Gu, F., He, Y., Xiang, J., Huang, X., Wang, Y., Chen, R."MicroRNA in adenoid cystic carcinoma (Review)". International Journal of Oncology 62.1 (2023): 17.
Chicago
Li, Y., Gu, F., He, Y., Xiang, J., Huang, X., Wang, Y., Chen, R."MicroRNA in adenoid cystic carcinoma (Review)". International Journal of Oncology 62, no. 1 (2023): 17. https://doi.org/10.3892/ijo.2022.5465