Open Access

Advances in understanding the role and mechanisms of tumor stem cells in HER2-positive breast cancer treatment resistance (Review)

  • Authors:
    • Linfei Xu
    • Fang Han
    • Liang Zhu
    • Wenli Ding
    • Kexin Zhang
    • Chengxia Kan
    • Ningning Hou
    • Qinying Li
    • Xiaodong Sun
  • View Affiliations

  • Published online on: February 28, 2023     https://doi.org/10.3892/ijo.2023.5496
  • Article Number: 48
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Approximately 15-20% of breast carcinomas exhibit human epidermal growth factor receptor (HER2) protein overexpression. HER2-positive breast cancer (BC) is a heterogeneous and aggressive subtype with poor prognosis and high relapse risk. Although several anti-HER2 drugs have achieved substantial efficacy, certain patients with HER2-positive BC relapse due to drug resistance after a treatment period. There is increasing evidence that BC stem cells (BCSCs) drive therapeutic resistance and a high rate of BC recurrence. BCSCs may regulate cellular self-renewal and differentiation, as well as invasive metastasis and treatment resistance. Efforts to target BCSCs may yield new methods to improve patient outcomes. In the present review, the roles of BCSCs in the occurrence, development and management of BC treatment resistance were summarized; BCSC-targeted strategies for the treatment of HER2-positive BC were also discussed.
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April-2023
Volume 62 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Xu L, Han F, Zhu L, Ding W, Zhang K, Kan C, Hou N, Li Q and Sun X: Advances in understanding the role and mechanisms of tumor stem cells in HER2-positive breast cancer treatment resistance (Review). Int J Oncol 62: 48, 2023.
APA
Xu, L., Han, F., Zhu, L., Ding, W., Zhang, K., Kan, C. ... Sun, X. (2023). Advances in understanding the role and mechanisms of tumor stem cells in HER2-positive breast cancer treatment resistance (Review). International Journal of Oncology, 62, 48. https://doi.org/10.3892/ijo.2023.5496
MLA
Xu, L., Han, F., Zhu, L., Ding, W., Zhang, K., Kan, C., Hou, N., Li, Q., Sun, X."Advances in understanding the role and mechanisms of tumor stem cells in HER2-positive breast cancer treatment resistance (Review)". International Journal of Oncology 62.4 (2023): 48.
Chicago
Xu, L., Han, F., Zhu, L., Ding, W., Zhang, K., Kan, C., Hou, N., Li, Q., Sun, X."Advances in understanding the role and mechanisms of tumor stem cells in HER2-positive breast cancer treatment resistance (Review)". International Journal of Oncology 62, no. 4 (2023): 48. https://doi.org/10.3892/ijo.2023.5496