Open Access

Advances in the treatment of Hodgkin's lymphoma (Review)

  • Authors:
    • Yuxuan Che
    • Xiaolei Ding
    • Liye Xu
    • Jian Zhao
    • Xian Zhang
    • Na Li
    • Xiuhua Sun
  • View Affiliations

  • Published online on: April 4, 2023     https://doi.org/10.3892/ijo.2023.5509
  • Article Number: 61
  • Copyright: © Che et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hodgkin's lymphoma (HL) is a unique B‑cell lymphoproliferative malignancy that has a critical pathogenesis characterized by a sparse population of Hodgkin and Reed‑Sternberg cells surrounded by numerous dysfunctional immune cells. Although systemic chemotherapy with or without radiotherapy, has significantly improved the prognosis of the majority of patients with HL, a subset of patients remains refractory to first‑line therapy or relapse after achieving an initial response. With the increased understanding of the biology and microenvironment of HL, novel strategies with notable efficacy and manageable toxicity, including targeted therapies, immunotherapy and cell therapy have emerged. The present review summarizes the progress made in developing novel therapies for HL and discusses future research directions in HL therapy.
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May-2023
Volume 62 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Che Y, Ding X, Xu L, Zhao J, Zhang X, Li N and Sun X: Advances in the treatment of Hodgkin's lymphoma (Review). Int J Oncol 62: 61, 2023.
APA
Che, Y., Ding, X., Xu, L., Zhao, J., Zhang, X., Li, N., & Sun, X. (2023). Advances in the treatment of Hodgkin's lymphoma (Review). International Journal of Oncology, 62, 61. https://doi.org/10.3892/ijo.2023.5509
MLA
Che, Y., Ding, X., Xu, L., Zhao, J., Zhang, X., Li, N., Sun, X."Advances in the treatment of Hodgkin's lymphoma (Review)". International Journal of Oncology 62.5 (2023): 61.
Chicago
Che, Y., Ding, X., Xu, L., Zhao, J., Zhang, X., Li, N., Sun, X."Advances in the treatment of Hodgkin's lymphoma (Review)". International Journal of Oncology 62, no. 5 (2023): 61. https://doi.org/10.3892/ijo.2023.5509